Navigation Links
Essentialis Meets Primary Endpoint in Phase 2b Trial of DCCR for Treatment of Hypertriglyceridemia and is Granted Extensive Patent Coverage in the US
Date:5/17/2009

due to AEs was in line with historic lipid-lowering trials.

Separately, the company further announced the allowance of a US patent covering DCCR. The patent entitled "Salts of potassium ATP channel openers and uses thereof" contains claims to salts of diazoxide - including DCCR - as well as pharmaceutical formulations of such salts. Additional applications filed in the US and globally will further enhance the patent portfolio of Essentialis.

Commenting on these developments, Essentialis President and CEO, Dr Iain Dukes said, "Essentialis has convincingly demonstrated the therapeutic utility of DCCR as a triglyceride lowering agent with a superior profile to existing approved drugs. The issuance of the patent covering DCCR provides timely coverage for its future commercial development."

Pivotal phase 3 protocols for very high triglycerides and phase 2 protocols for statin combination therapy are currently being finalized with input from experts and the FDA in parallel with partnering discussions.

About DCCR

DCCR, diazoxide choline controlled release, is an ATP-dependent potassium channel agonist with potential utility in several cardiovascular and metabolic diseases. Extensive Phase 1 testing and investigator-sponsored clinical studies have demonstrated the drug's potential to lower triglycerides, non-HDL cholesterol and LDL-cholesterol while raising HDL-cholesterol. In addition, placebo adjusted weight loss exceeding 5% in an 8-week placebo controlled study and 10% in a 6-month study has been demonstrated. Compositions of matter, formulation and method of use patents for DCCR have been filed worldwide. A fixed dose combination product with a statin is under development.

About Very High Triglycerides

Hypertriglyceridemia, a disease where patients have high blood levels of triglycerides, is associated with increased risk of coronary heart disease
'/>"/>

SOURCE Essentialis
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Essentialis Completes Patient Enrollment in Phase 2 Trial of DDCR for Treatment of Dyslipidemia
2. Genzyme Announces Second Pivotal Mozobil Trial Meets Primary Endpoint
3. ERBITUX(R) Meets Primary Endpoint of Increasing Survival in Phase III Lung Cancer Study
4. Anesiva Announces Pivotal Phase 3 Trial of Zingo(TM) Meets Primary Endpoint and Significantly Reduces Venous Access Pain in Adults
5. Tezampanel Meets Primary Endpoint in Phase IIb Clinical Trial in Acute Migraine Headache
6. A Phase II, Randomized, Double Blind, Placebo-Controlled Dose-Escalating Study, Meets the Clinical Endpoints of MTR106 Tablets During the Treatment of Acute Migraine Attacks Without Aura in Females
7. ADVENTRX Meets Primary Endpoint in ANX-530 Marketing-Enabling Clinical Study
8. Second Phase III Study of Avastin in 1st Line Metastatic Breast Cancer Meets its Primary Endpoint
9. Alexzas AZ-104 (Staccato(R) Loxapine) Phase 2a Trial Meets Primary Endpoint of 2-Hour Pain Relief in Patients with Migraine Headache
10. Abbotts Phase III Studies of Investigational TriLipix(TM) (ABT-335), in Combination With Statins, Meets Primary Endpoints on Improving LDL, Triglycerides and HDL
11. Phase III Study of Abbotts Investigational TriLipix(TM) in Combination With AstraZenecas CRESTOR(R) Meets Primary Endpoints on Key Lipids
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/28/2015)... 28, 2015  The recent flurry of PBM ... employer groups scrambling to identify a pharmacy benefit ... care plan, retail pharmacy chain, or other potentially ... purchase of Catamaran, Rite Aid,s $2 billion acquisition ... Omni-Care for $10 billion are just the latest ...
(Date:5/28/2015)... May 28, 2015 The Federal Trade ... antitrust suit charging Cephalon, Inc. with illegally blocking ... The settlement ensures that Teva Pharmaceutical Industries, Ltd., ... total of $1.2 billion available to compensate purchasers, ... because of Cephalon,s illegal conduct.  ...
(Date:5/28/2015)... , May 28, 2015 Lungpacer Medical, ... catheter-based phrenic-nerve-pacing system announced today that it will ... Conference on Thursday, June 4, 2015 in New ... 11:30 a.m. Eastern Time.   About ... a preclinical stage medical device company pioneering the ...
Breaking Medicine Technology:Citizens Rx Addresses Recent PBM Consolidation and Rising Pharmacy Costs 2Citizens Rx Addresses Recent PBM Consolidation and Rising Pharmacy Costs 3FTC Settlement of Cephalon Pay for Delay Case Ensures $1.2 Billion in Ill-Gotten Gains Relinquished; Refunds Will Go To Purchasers Affected By Anticompetitive Tactics 2FTC Settlement of Cephalon Pay for Delay Case Ensures $1.2 Billion in Ill-Gotten Gains Relinquished; Refunds Will Go To Purchasers Affected By Anticompetitive Tactics 3
... Conn., Sept. 23, 2011 Butrans® (Buprenorphine) Transdermal System ... pain over the last 24 hours" scores compared to ... moderate-to-severe chronic low back pain , according to ... online, August issue of The Journal of Pain ...
... 2011 Take Care Health Systems, a wholly-owned subsidiary ... Sanofi US today announced the opening of a full-service ... in Bridgewater, New Jersey. (Logo: http://photos.prnewswire.com/prnh/20110616/NY20158LOGO) ... dedicated to solving health challenges, it is essential for ...
Cached Medicine Technology:Results of a Pivotal Phase 3 Efficacy and Safety Study for Butrans® (Buprenorphine) Transdermal System CIII Published in The Journal of Pain 2Results of a Pivotal Phase 3 Efficacy and Safety Study for Butrans® (Buprenorphine) Transdermal System CIII Published in The Journal of Pain 3Results of a Pivotal Phase 3 Efficacy and Safety Study for Butrans® (Buprenorphine) Transdermal System CIII Published in The Journal of Pain 4Results of a Pivotal Phase 3 Efficacy and Safety Study for Butrans® (Buprenorphine) Transdermal System CIII Published in The Journal of Pain 5Results of a Pivotal Phase 3 Efficacy and Safety Study for Butrans® (Buprenorphine) Transdermal System CIII Published in The Journal of Pain 6Walgreens Take Care Health Systems and Sanofi US Open On-site Medical Center and Pharmacy 2Walgreens Take Care Health Systems and Sanofi US Open On-site Medical Center and Pharmacy 3Walgreens Take Care Health Systems and Sanofi US Open On-site Medical Center and Pharmacy 4Walgreens Take Care Health Systems and Sanofi US Open On-site Medical Center and Pharmacy 5
(Date:5/28/2015)... Restricting access to firearms for people who ... more clearly define alcohol misuse should be developed to ... and public policies by the UC Davis Violence Prevention ... in the peer-reviewed journal Preventive Medicine , summarizes ... misuse in association with firearm access and use, including ...
(Date:5/28/2015)... 28, 2015 AMVETS leaders this week ... winner Robert Davis of Newark, Del. AMVETS National Commander ... on winning the $10,000 sweepstakes grand prize. , AMVETS ... entries from around the country for prizes ranging from ... place on May 21 at the AMVETS National Headquarters ...
(Date:5/28/2015)... The Paw Project, an international ... intended to educate the Oregon public about the harmful ... of Market Street and Park Avenue in Salem, Oregon's ... De-clawing Cats, Raise Your Hand,” depicts a human hand ... a graphic and anatomically-correct representation of the declaw surgery ...
(Date:5/28/2015)... PA (PRWEB) May 28, 2015 The ... today announced a just launched blog series which provides ... Hosted on the “R. Bruce Dalglish” profile on ... of R. Bruce Dalglish’s corporate experience. , “Throughout ... positive workplace cultures have upon the overall success of ...
(Date:5/28/2015)... Ticket Down is a reputable source of ... Mexico and Argentina in early September. , Two of ... on the pitch at AT&T Stadium in Arlington/Dallas, TX. Mexico ... friendly on Tuesday, September 8th at 9 p.m. The match ... world including some of the most loved players in the ...
Breaking Medicine News(10 mins):Health News:UC Davis Research Finds That Restricting Firearms Access for People who Misuse Alcohol May Prevent Violence 2Health News:UC Davis Research Finds That Restricting Firearms Access for People who Misuse Alcohol May Prevent Violence 3Health News:UC Davis Research Finds That Restricting Firearms Access for People who Misuse Alcohol May Prevent Violence 4Health News:AMVETS Announces Summer Sweepstakes Winners 2Health News:Declawing is Cruel, Education is the Key - Says the Paw Project 2Health News:Declawing is Cruel, Education is the Key - Says the Paw Project 3Health News:R. Bruce Dalglish, CEO of Alliance Hospice, Introduces New Blog Series On Positive Corporate Culture 2Health News:Mexico vs. Argentina Tickets at AT&T Stadium: Ticket Down Slashes Ticket Prices on Argentina vs. Mexico Presale Tickets at AT&T Stadium for 9/8/15 Friendly Match 2Health News:Mexico vs. Argentina Tickets at AT&T Stadium: Ticket Down Slashes Ticket Prices on Argentina vs. Mexico Presale Tickets at AT&T Stadium for 9/8/15 Friendly Match 3
... of C.difficile’s genetic code is reported to have been ... will enable faster diagnosis and treatment of the ailment ... to the Jewish General Hospital’s Dasval. The strain has ... in Quebec. The search can now commence for the ...
... Schepens Eye Research Institute (SERI) found that increasing the ... more enjoyable to the visually impaired. // ,The ... electronic device to help millions suffering eye diseases. People ... suffering from macular degeneration, diabetic retinopathy and other causes ...
... the first to visualize a need for laboratories in the Mexican ... Sustainability Laboratory (BNSL), which extends over an area of 4000 square ... security force and deal with terrorism // with the help ... for the lab come from USA, State of New Mexico and ...
... study done by a researcher Yun Zhang at the Rockefeller ... of worms. // ,The research was mainly conducted on ... the soil and feeds on various bacteria (both harmless and ... to individual behaviors. ,The genes responsible for the ...
... Annals of Internal Medicine this week have found that ... verge of kidney failure is useless. //The study conducted ... London, Canada found that a treatment called "plasma exchange" ... ,This means that the money which is currently ...
... Wahangara, 12 year old boy from Indonesia had a tumor ... the tumor made up around 10% of his body weight.// ... at Mount Elizabeth Hospital involving different specialties. ,The ... an endemic problem in Sumba. The 7.87 inches tumor developed ...
Cached Medicine News:Health News:Visually impaired prefer specially enhanced TV 2Health News:Visually impaired prefer specially enhanced TV 3Health News:Worms Learn To Choose Their Diet 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: