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ErtelAlsop Launches Unique, Cost-Effective, Single-Use Capsules for Biopharmaceutical Applications
Date:7/9/2013

KINGSTON, N.Y., July 9, 2013 /PRNewswire/ -- Processing for the biotechnology industry demands efficient, scalable filtration technology. ErtelAlsop has addressed this issue with a suite of versatile depth filtration products that simplify testing and scale-up. MicroCap™ disposable capsule filters do not require costly and exhausting changeouts to deliver the on-stream performance necessary for process scale batches ranging from .05 to more than 50 liters. They eliminate the need for expensive, inefficient pooling of multiple batches for primary separations/prefiltration, secondary clarification, cell culture harvest, and cell culture clarification.

These disposable capsules offer sizes, effective filter area, and connection styles to suit laboratory through production batch processing. MicroCap capsules are offered in 6 different sizes from 23 cm2 single-layer/double-layer to 2880 cm2 single-layer and 1500 cm2 double-layer. They comprise 12 different depth filter media grades ranging from 0.2 microns to 15 microns for quick and efficient process development and optimization during scale-up and scale-down studies with linear scalability. These capsules offer low hold-up volumes and reduced post‑use rinsing volumes for enhanced product recovery, as well as complete disposability, requiring no cleaning and cleaning validation. According to Scott Anderson, the Product Manager for Single-Use Technologies at ErtelAlsop, "MicroCap capsules offer highly predictable scale-up and can eliminate the need for changeouts during batch processing."

MicroCap capsules are designed to ensure operator safety and minimize product loss. Their sealed design eliminates direct operator handling of fragile filter discs and protects operators from biologically toxic compounds. In addition, depth filter sheets are supported on both the upstream and downstream sides, minimizing the potential for high‑pressure blowouts.

MicroCap depth filter capsules are available in single and double-layer as well as activated carbon formats. Single-layer formats are effective for processes requiring lower contaminant removal such as high cell viability or low particle size distribution applications. Double-layer formats are better suited for applications containing higher debris loads and particle size distributions typical in modern biopharmaceutical applications. Activated carbon formats are effective for decolorization and odor removal.

ErtelAlsop has complemented the suite with the compact and easily accessible MicroCap Laboratory Cabinet for MC1 single-use depth filter capsules for simplified filtration and separation research and development trials.

As part of its MicroCap rollout, ErtelAlsop anticipates complementing the MicroCap Suite with a full size single-use system for large scale batch processing in 2013.

 


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