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Epratuzumab Phase IIb Data Presented at ACR Show Pipeline Drug had Positive Effect in Patients Suffering From Moderate to Severe Systemic Lupus Erythematosus
Date:11/9/2010

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** BILAG (British Isles Lupus Assessment Group) is a comprehensive scoring system for assessing both current SLE disease activity and changes in that activity since the patient was last seen.For further informationScott Fleming, Global Communications Manager – ImmunologyTel: +44.770.277.7378, scott.fleming@ucb.com Nancy Nackaerts, External Communications, UCBTel: +32 473 86 44 14, nancy.nackaerts@ucb.comMichael Tuck-Sherman, Investor Relations, UCBTel: +32.2.559.9712, michael.tuck-sherman@ucb.com  Richard Simpson, Investor Relations, UCBTel: +32.2.559.9494, richard.simpson@ucb.comAntje Witte, Investor Relations, UCBTel: +32 2559 9414 / +492173481866, antje.witte@ucb.comAbout EpratuzumabEpratuzumab is a humanized anti-CD22 monoclonal antibody under investigation for the treatment of SLE. CD22 is a B cell specific surface protein that is considered to be involved in B cell function.  The product was licensed from Immunomedics, Inc., Morris Plains, NJ, USA. Under the license agreement, UCB owns the rights and is responsible for the clinical development, and commercialization of epratuzumab in all autoimmune disorders including SLE.

About EMBLEM™In EMBLEM™ (n = 227) patients were randomized to 1 of 6 intravenous regimens: placebo (PBO), epratuzumab cumulative dose (cd) 200, 800, 2400, or 3600 mg in equal divided doses using 2 every other week (EOW) infusions or epratuzumab cd 2400 mg delivered as 4 equal infusions 1 week apart. Concomitant oral corticosteroids (CS) and immunosuppressives (IS) were stable
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