Navigation Links
Epizyme's EPZ-5676 DOT1L Inhibitor Demonstrates Encouraging Initial Findings in an Ongoing Phase 1 Dose Escalation Study
Date:11/14/2013

CAMBRIDGE, Mass., Nov. 14, 2013 /PRNewswire/ --

  • Four dose cohorts (12, 24, 36 and 54 mg/m2/day) completed (16 patients, 8 with acute leukemia with MLL-r) with 21-day on/7-day off administration schedule
  • Observations to date include:
    • No dose-limiting toxicities; maximum tolerated dose (MTD) not reached
    • Treatment effects, consistent with genetically defined therapeutic mechanism of action, observed in 4 of 8 acute leukemia patients with MLL-rearrangement (MLL-r); no effects observed in non-MLL-r patients
    • Dose-proportional exposure
    • Dose- and time-dependent methyl mark inhibition
  • Plan to initiate Phase 1 MLL-r only expansion stage in December 2013 starting at an 80 mg/m2/day uninterrupted treatment schedule, continued dose escalation possible
  • Epizyme will host a conference call and live audio webcast today at 8:30 a.m. ET to discuss these data; slides will be available on www.epizyme.com prior to call

Epizyme, Inc. (NASDAQ: EPZM), a clinical stage biopharmaceutical company creating innovative personalized therapeutics for patients with genetically defined cancers, today announced initial findings from an ongoing Phase 1 study of EPZ-5676, a potent and selective inhibitor of the DOT1L histone methyltransferase (HMT) being developed for the treatment of acute leukemia with alterations in the MLL gene.

"EPZ-5676 is a first-in-class inhibitor of the DOT1L HMT, and we are very pleased with the findings to date in the dose escalation stage of the ongoing two-stage Phase 1 study," said Robert J. Gould, Ph.D., chief executive officer, Epizyme. "The safety,
'/>"/>

SOURCE Epizyme, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Epizyme, Inc. Granted Notice of Allowance of Patent for EPZ-5676
2. Epizyme Receives Orphan Drug Designation for EPZ-5676
3. Epizyme, Inc. to Present Pre-Clinical Data on DOT1L and EZH2 Inhibitor Programs at the 55th ASH Annual Meeting
4. Epizyme to Partner to Develop DOT1L Companion Diagnostic
5. 3-V Biosciences Presents Positive Data for Novel FASN Inhibitor at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
6. MEI Pharmas Mitochondrial Inhibitor ME-344 Shows Preliminary Evidence of Single-Agent Activity in First-in-Human Clinical Study
7. Among Newly Diagnosed Type 2 Diabetes Patients, DPP-IV Inhibitors are the Leading Oral Therapies After Standard Metformin and Sulfonylurea
8. MEI Pharma Acquires PWT143, A Highly Selective PI3-Kinase Delta Inhibitor
9. Neurocrine Announces Phase IIb Results Of VMAT2 Inhibitor NBI-98854 For Treatment Of Tardive Dyskinesia
10. Halozyme Provides Update on ViroPharma Phase 2 Trial of Subcutaneous Cinryze (C1 Esterase Inhibitor [Human]) Formulation with rHuPH20
11. Diabetes Therapeutics Market in India to 2018 - Rapid Uptake of DPP-IV Inhibitors, GLP-1 Agonists and Expanding Insulin Segment to Drive Growth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2014)... , Aug. 19, 2014  The Alabama Supreme Court, ... patients can sue drug makers who mislead doctors into believing ... side‑effects.  The case is Weeks v. Wyeth, and the decision ... in that same case last year. Heninger Garrison Davis attorneys ... the patient in the case, Danny Weeks . ...
(Date:8/19/2014)... 2014 Minimally Invasive Devices Inc. (MID), a ... announced today that Mitsubishi Corporation has formally agreed to ... in Japan . MID anticipates that ... Japan in the second half of 2015. ... for Karl Storz GMBH & Co. (endoscopic instruments and ...
(Date:8/19/2014)...  As power morcellator lawsuits continue to mount ... notes that women in need of fibroid removal ... options that do not involve the use of ... report published by The Wall Street Journal on ... mini-laparotomy and vaginal hysterectomy. Non-surgical options for shrinking ...
Breaking Medicine Technology:Heninger Garrison Davis Clients To Get Their Day in Court Against Brand Drug Companies 2Heninger Garrison Davis Clients To Get Their Day in Court Against Brand Drug Companies 3Heninger Garrison Davis Clients To Get Their Day in Court Against Brand Drug Companies 4Minimally Invasive Devices and Mitsubishi Medical Japan Forge Exclusive Distribution Agreement 2As Morcellator Lawsuits Mount, Bernstein Liebhard LLP Notes Report Detailing Alternatives to Uterine Morcellation 2As Morcellator Lawsuits Mount, Bernstein Liebhard LLP Notes Report Detailing Alternatives to Uterine Morcellation 3
... Valeant Pharmaceuticals International, Inc. (NYSE/TSX: VRX) today ... credit facilities of its wholly owned subsidiary Valeant ... by the Company.  The proposed $1.7 billion senior ... a $200 million revolving facility and a $1.5 ...
... 20, 2011 – Ingenuity® Systems, a leading ... life science researchers, today announced the addition ... from miRecords , plus thousands of ... peer-reviewed literature. The newly added content supplements ...
Cached Medicine Technology:Valeant Pharmaceuticals to Refinance Senior Secured Credit Facilities 2Ingenuity Announces New Additional MicroRNA Content to Complement First-of-its-Kind MicroRNA Filtering Capability in IPA 2
(Date:8/19/2014)... Crosley Law Firm, PC has reached a confidential settlement ... Bakery for an undisclosed amount. The two claimants, Pete Gonzales ... 2011, respectively. The injuries were caused by two different machines ... the left hand of each man. , At the time ... having lost 200 of its, 500 workers in connection with ...
(Date:8/19/2014)... An editorial published in this week,s JAMA ... clinical assessment tools when considering how to treat patients. ... Boston Medical Center and chair of pediatrics at Boston ... of JAMA , the editorial examines results of ... journal as an example of how doctors can often ...
(Date:8/19/2014)... (PRWEB) August 19, 2014 Kars4Kids ... youth programs, announced today its partnership with New York ... needy students in the Bronx. The giveaway will take ... Fair in Crotona Park on August 22. , ... opportunities, we believe properly preparing children for school with ...
(Date:8/19/2014)... “ Inbox Blueprint 2.0 ” from ... provide users with the tools necessary to build and ... strategies. The course which was originally launched in ... the internet marketing world. The commotion surrounding the products ... prompting an updated review of the course material. ...
(Date:8/19/2014)... TUESDAY, Aug. 19, 2014 (HealthDay News) -- Lupus ... such as headaches and seizures, which can delay ... says. Treatments for rheumatic diseases can also ... at Loyola University Medical Center in Maywood, ... of the joints and soft tissues, such as ...
Breaking Medicine News(10 mins):Health News:Crosley Law Firm Reaches Settlement for Hand Amputation Victims at Commercial Bakery 2Health News:Review of clinical treatment of bronchiolitis in infants reveals over-reliance on one test 2Health News:Backpack Giveaway Kars4Kids Partners with New York State Senator Gustavo Rivera to Prepare Bronx Students for New School Year 2Health News:Anik Singal’s “Inbox Blueprint” Review Released By HonestyFirstReviews.com 2Health News:Certain Symptoms Can Delay Lupus Diagnosis, Researchers Report 2
... plot, emotional melodrama is a subtype of dramatic ... part of the consumer. Often labelled chick-flicks, tearjerkers, ... form of entertainment is underscored by the popularity ... Oprah Winfrey Show. However, despite the apparent popularity ...
... GAINESVILLE, Fla. --- If the human body were a ... in the play we call Life. , These ... lines are dictated by information encoded in our genes. ... living and controlling countless functions. Many are enzymes that ...
... a 1990 consensus recommendation from the National Institutes of ... of choice for early stage breast cancer, the United ... surgery among industrialized countries. Why would a person knowingly ... a lesser one would suffice? A recent survey shows ...
... Prevent Sudden Cardiac Arrest,Through Public Education and Advocacy, ... announced today that it has launched a Southwest,Connecticut chapter ... affiliate,organizations, as it builds a network of local organizations ... arrest (SCA)., The Southwest Connecticut chapter is based ...
... Will Work to Prevent Sudden Cardiac Arrest, Through ... The Sudden Cardiac Arrest,Association (SCAA) announced today that it ... network of local organizations to help carry out its,mission ... Kansas City SCAA chapter is led by Patrick Emmett ...
... Work to Prevent Sudden Cardiac Arrest, Through Public ... Sudden Cardiac Arrest,Association (SCAA) announced today that it has ... of local organizations to help carry out,its mission of ... chapter is led by Connie Snell of Austin who ...
Cached Medicine News:Health News:True story? Men prefer 'chick flicks' when they are explicitly fictionalized 2Health News:Protein power: Researchers trigger insulin production in diabetic mice 2Health News:Protein power: Researchers trigger insulin production in diabetic mice 3Health News:American women are more likely to choose overly aggressive treatments for breast cancer 2Health News:Sudden Cardiac Arrest Association Launches Southwest Connecticut Chapter 2Health News:Sudden Cardiac Arrest Association Launches Southwest Connecticut Chapter 3Health News:Sudden Cardiac Arrest Association Launches Kansas City Chapter 2Health News:Sudden Cardiac Arrest Association Launches Kansas City Chapter 3Health News:Sudden Cardiac Arrest Association Launches Austin and Lubbock Chapters 2Health News:Sudden Cardiac Arrest Association Launches Austin and Lubbock Chapters 3
... The Brasseler USA™ Battery Packs contain ... age have a great impact upon battery ... is necessary. Any deviation from these recommendations ... are sensitive to heat. Any exposure of ...
Pneumatic High-speed Drill, Throttleless, 90k Rpm, Microaire Connector....
Pneumatic foot surgical oscillating saw, 24k cpm, available with various hose connector styles....
... Motor Module, without throttle (MicroAire hose connector). ... attachments., ,1050-100 model requires 10ft. ... MicroAire connector. Also requires 9100-000 Foot Control ... hose 9013-000, or existing hose with Linvatec/Hall ...
Medicine Products: