Navigation Links
Epizyme's EPZ-5676 DOT1L Inhibitor Demonstrates Encouraging Initial Findings in an Ongoing Phase 1 Dose Escalation Study
Date:11/14/2013

CAMBRIDGE, Mass., Nov. 14, 2013 /PRNewswire/ --

  • Four dose cohorts (12, 24, 36 and 54 mg/m2/day) completed (16 patients, 8 with acute leukemia with MLL-r) with 21-day on/7-day off administration schedule
  • Observations to date include:
    • No dose-limiting toxicities; maximum tolerated dose (MTD) not reached
    • Treatment effects, consistent with genetically defined therapeutic mechanism of action, observed in 4 of 8 acute leukemia patients with MLL-rearrangement (MLL-r); no effects observed in non-MLL-r patients
    • Dose-proportional exposure
    • Dose- and time-dependent methyl mark inhibition
  • Plan to initiate Phase 1 MLL-r only expansion stage in December 2013 starting at an 80 mg/m2/day uninterrupted treatment schedule, continued dose escalation possible
  • Epizyme will host a conference call and live audio webcast today at 8:30 a.m. ET to discuss these data; slides will be available on www.epizyme.com prior to call

Epizyme, Inc. (NASDAQ: EPZM), a clinical stage biopharmaceutical company creating innovative personalized therapeutics for patients with genetically defined cancers, today announced initial findings from an ongoing Phase 1 study of EPZ-5676, a potent and selective inhibitor of the DOT1L histone methyltransferase (HMT) being developed for the treatment of acute leukemia with alterations in the MLL gene.

"EPZ-5676 is a first-in-class inhibitor of the DOT1L HMT, and we are very pleased with the findings to date in the dose escalation stage of the ongoing two-stage Phase 1 study," said Robert J. Gould, Ph.D., chief executive officer, Epizyme. "The safety,
'/>"/>

SOURCE Epizyme, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Epizyme, Inc. Granted Notice of Allowance of Patent for EPZ-5676
2. Epizyme Receives Orphan Drug Designation for EPZ-5676
3. Epizyme, Inc. to Present Pre-Clinical Data on DOT1L and EZH2 Inhibitor Programs at the 55th ASH Annual Meeting
4. Epizyme to Partner to Develop DOT1L Companion Diagnostic
5. 3-V Biosciences Presents Positive Data for Novel FASN Inhibitor at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
6. MEI Pharmas Mitochondrial Inhibitor ME-344 Shows Preliminary Evidence of Single-Agent Activity in First-in-Human Clinical Study
7. Among Newly Diagnosed Type 2 Diabetes Patients, DPP-IV Inhibitors are the Leading Oral Therapies After Standard Metformin and Sulfonylurea
8. MEI Pharma Acquires PWT143, A Highly Selective PI3-Kinase Delta Inhibitor
9. Neurocrine Announces Phase IIb Results Of VMAT2 Inhibitor NBI-98854 For Treatment Of Tardive Dyskinesia
10. Halozyme Provides Update on ViroPharma Phase 2 Trial of Subcutaneous Cinryze (C1 Esterase Inhibitor [Human]) Formulation with rHuPH20
11. Diabetes Therapeutics Market in India to 2018 - Rapid Uptake of DPP-IV Inhibitors, GLP-1 Agonists and Expanding Insulin Segment to Drive Growth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... DALLAS , Jan. 15, 2014 /PRNewswire-iReach/ -- ... research report to its store . ... from aging of population, consumption upgrade and policy ... industry has seen rapid development over the years, ... yuan in 2006 to 9.85 billion yuan in ...
(Date:1/15/2014)... AARP Foundation today announced it has established a ... the severe cold weather that has gripped much of ... helping those in need; so to support these emergency ... contributions up to $250,000, which could mean up to ... through AARP Foundation. (Logo: http://photos.prnewswire.com/prnh/20070209/NYF043LOGO ...
(Date:1/15/2014)... 2014 Shire plc (LSE: SHP, NASDAQ: ... Office of Fair Trading (OFT) approval condition to the announced ... Incorporated (NASDAQ: VPHM).   As a result of ... approval, and Shire expects to complete the tender offer on ... to the satisfaction of all of the remaining conditions to ...
Breaking Medicine Technology:Orthopedic Instrument Industry in China Markets Forecast to 2015 2Orthopedic Instrument Industry in China Markets Forecast to 2015 3AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 2AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 3Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 3
(Date:4/14/2014)... orphaned by HIV/AIDS in South Africa may provide insight ... behavior issues in other areas of the world, which ... that could lead to successful interventions. , A ... United Nations mentions that due to the HIV/AIDS pandemic, ... African, children are at an increased risk for mental ...
(Date:4/14/2014)... A new study shows that moderate to severe ... risk of stroke, cancer and death. , Results of ... to severe obstructive sleep apnea were four times more ... times more likely to have a stroke (HR = ... (HR = 3.4), and 2.5 times more likely to ...
(Date:4/14/2014)... Dallas study involving serious youth offenders, the answer to one ... seven years: "How long do you think you,ll live?", According ... offending over time., Author Dr. Alex Piquero said the study ... of them offend at very high rates and commit more ... much later in life offend much less., "In a lot ...
(Date:4/14/2014)... with symptoms increasing dramatically during some of the most important ... has found. , Depressive symptoms increased on average by 68 ... young men, who were around 25 years old when they ... their children. The results of the study were published April ... is the first to identify when young fathers are at ...
(Date:4/14/2014)... Lower weight babies and babies who aren,t breastfed ... risk of developing chronic inflammation and related health ... study. , "There were good reasons to hypothesize ... inflammation in adulthood," says Thomas McDade (Northwestern University), ... in the Child & Brain Development program. "It ...
Breaking Medicine News(10 mins):Health News:Researchers identify children with emotional behavior difficulties 2Health News:Researchers identify children with emotional behavior difficulties 3Health News:Study links severe sleep apnea to increased risk of stroke, cancer and death 2Health News:UT Dallas study: Youth who fail to envision future commit more crimes 2Health News:Young dads at high risk of depression, too 2Health News:Low birth weight, less breastfeeding create later health risks 2
... , NEW ORLEANS, July 14 Ochsner Medical Center ... in Louisiana, and one of only a handful in the nation. ... living-donor kidney transplants easier on the donor by using smaller incisions, ... the operation in July 2009 with successful outcomes for the recipient ...
... study found that the clinical criteria for mild ... Alzheimer,s disease than a single memory test. This ... identification and early treatment of individuals most likely to develop ... Association International Conference on Alzheimer,s Disease on July 14 in ...
... 19th century infant deaths attributed to smothering and overlaying, ... likelihood crib deaths, or Sudden Infant Death Syndrome (SIDS). ... neglect and even infanticide, because SIDS had not yet ... researcher from Scottsdale, Arizona, USA. Her findings (1) are ...
... , , WASHINGTON, July 14 Amanda Crawford ... 45, she still smokes despite having tried to quit multiple times. Children are ... smokes - and in Crawford,s case, it was her father who smoked. Born ... smoker - in Roanoke. The Crawfords now have three sons - 28, 14 ...
... , , , , ... announces the launch of HealthPROSe ... a new and trusted voice on health policy and related socioeconomic issues. ... debate with engaging, focused commentaries on national and global health policy concerns. ...
... , SAN DIEGO, July 14 ... inhibitor, prasugrel (Effient), Accumetrics, Inc. announces that its VerifyNow P2Y12 ... but also its newly approved competitor, Effient. In obtaining a ... to determine the response of an individual patient to their ...
Cached Medicine News:Health News:Ochsner 1st in Louisiana to use Robotics in Living-Donor Kidney Transplant for Faster Recovery 2Health News:Mayo Clinic study continues to refine most effective methods to predict Alzheimer's disease 2Health News:New Survey Highlights Emotional, Financial Toll Multi-Generational Tobacco Use Takes on Parents Sandwiched In Between 2Health News:New Survey Highlights Emotional, Financial Toll Multi-Generational Tobacco Use Takes on Parents Sandwiched In Between 3Health News:New Survey Highlights Emotional, Financial Toll Multi-Generational Tobacco Use Takes on Parents Sandwiched In Between 4Health News:HealthPROSe Brings Creative, Strategic Thinking to Health Blogosphere 2Health News:Accumetrics' VerifyNow(R) P2Y12 Test Provides Physicians With Information to Assess a Patient's Response to Newly-Approved Prasugrel (Effient(R)) 2
... onboard rail clamps mount ... tables and stretchers. The ... need for lifting. Easy ... stable surface combined with ...
The DHS Basic Set is available with either self-tapping or non-self-tapping screws. Either instrument set provides complete instrumentation in one graphic case for use with the Universal Implant Set,...
... is a versatile, fully powered orthopaedic and ... traction facilities, a powered centre break and ... versatile too. ,<br.,In fact the RX600 is ... it is for traction procedures. The RX600 ...
... orthopedic trauma procedures. Part of the ... trauma table top provides a complete, ... positioning and provides for skin or ... hip pinnings; femur, supine or lateral ...
Medicine Products: