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Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day
Date:8/22/2014

ical company creating personalized therapeutics for patients with genetically defined cancers. Epizyme has built a proprietary product platform that the company uses to create small molecule inhibitors of a 96-member class of enzymes known as histone methyltransferases, or HMTs.

HMTs are part of the system of gene regulation, referred to as epigenetics, that controls gene expression. Genetic alterations can result in changes to the activity of HMTs, making them oncogenic (cancer-causing). By focusing on the genetic drivers of cancers, Epizyme's targeted science seeks to match the right medicines with the right patients for a personalized approach to cancer treatment.

Writing for TheStreet.com this week, David Sobek summed up the pre-clinical data and early clinical observations from an ongoing Phase I trial...

"Epizyme reported the first clinical data on its blood cancer pipeline candidate EPZ-6438 at the ASH Lymphoma Biology Conference last week. The drug is designed to block a specific enzyme, EZH2, which when mutated, is involved in development of certain cancers, including forms of non-Hodgkins lymphoma (NHL).

Bear of the Day:

Some "fast casual" eateries seem to have growing appeal and profits, like Chipotle, and some are really struggling like Panera (Nasdaq: PNRA-Free Report). I actually like Panera a lot -- best oatmeal raisin cookies, and I am an aficionado here -- but the stock has been in a sharp decline since its peak in Q1 above $190 and there's a good reason for it: falling profits.

In the past 90 days, 13 analysts have lowered f
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SOURCE Zacks Investment Research, Inc.
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Related medicine technology :

1. Epizyme, Inc. Files Registration Statement for Proposed Initial Public Offering
2. Epizyme, Inc. Announces Pricing of Initial Public Offering
3. Epizyme, Inc. to Webcast Conference Call Discussing Second Quarter 2013 Financial Results on July 31, 2013
4. Epizyme, Inc. to Present at Wedbush Securities Life Sciences Management Access Conference in August
5. Epizyme, Inc. to Present at Upcoming Conferences in September
6. Epizyme, Inc. Granted Notice of Allowance of Patent for EPZ-5676
7. Epizyme, Inc. to Present at Upcoming Conferences in November
8. Epizyme, Inc. to Present Pre-Clinical Data on DOT1L and EZH2 Inhibitor Programs at the 55th ASH Annual Meeting
9. Epizyme, Inc. to Present at 32nd Annual J.P. Morgan Healthcare Conference
10. Cell Therapeutics, Inc. (CTI) to Report First Quarter Financial Results on April 20
11. Zenobia Therapeutics, Inc. And BioBlocks, Inc. Announce Sale Of A Joint Fragment Library Ideal For Screening By All Popular Methods
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