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Epizyme, Inc. to Present Pre-Clinical Data on DOT1L and EZH2 Inhibitor Programs at the 55th ASH Annual Meeting
Date:11/7/2013

CAMBRIDGE, Mass., Nov. 7, 2013 /PRNewswire/ -- Epizyme, Inc. (NASDAQ: EPZM), a clinical stage biopharmaceutical company creating innovative personalized therapeutics for patients with genetically defined cancers, will present pre-clinical data on EPZ-5676 and EPZ-6438, the Company's DOT1L and EZH2 clinical programs, at the 55th Annual Meeting of the American Society of Hematology (ASH) in New Orleans on December 7-10, 2013.

"EPZ-5676, our DOT1L inhibitor, and EPZ-6438, our EZH2 inhibitor, are currently being developed as single-agent treatments based on the durable tumor regressions seen in pre-clinical studies," said Robert A. Copeland, Ph.D., executive vice president and chief scientific officer, Epizyme. "Two of our ASH presentations highlight the synergistic efficacy we have demonstrated in pre-clinical combination studies with each of our clinical candidates in specific genetically defined tumors. These data point us towards the potential use of our therapeutic candidates in combination treatment settings. Additionally, we are pleased to present data at ASH highlighting the opportunity to pursue a second genetically defined cancer, MLL-PTD, with EPZ-5676. MLL-PTD represents a distinct genetically defined acute leukemia in addition to our current clinical focus on MLL-r."

EPZ-5676, an inhibitor of the histone methyltransferase (HMT) DOT1L, is being developed as a treatment for patients with acute leukemias with rearrangements of the MLL gene (MLL-r). In the fourth quarter of 2013, Epizyme plans to announce top-line dose escalation data from the ongoing Phase 1 clinical study and, based on this data, initiate an expansion cohort stage that will be limited to patients with MLL-r.

EPZ-6438 is an inhibitor of the HMT EZH2 being developed as a tr
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SOURCE Epizyme, Inc.
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