Navigation Links
Epizyme, Inc. to Present Pre-Clinical Data on DOT1L and EZH2 Inhibitor Programs at the 55th ASH Annual Meeting
Date:11/7/2013

CAMBRIDGE, Mass., Nov. 7, 2013 /PRNewswire/ -- Epizyme, Inc. (NASDAQ: EPZM), a clinical stage biopharmaceutical company creating innovative personalized therapeutics for patients with genetically defined cancers, will present pre-clinical data on EPZ-5676 and EPZ-6438, the Company's DOT1L and EZH2 clinical programs, at the 55th Annual Meeting of the American Society of Hematology (ASH) in New Orleans on December 7-10, 2013.

"EPZ-5676, our DOT1L inhibitor, and EPZ-6438, our EZH2 inhibitor, are currently being developed as single-agent treatments based on the durable tumor regressions seen in pre-clinical studies," said Robert A. Copeland, Ph.D., executive vice president and chief scientific officer, Epizyme. "Two of our ASH presentations highlight the synergistic efficacy we have demonstrated in pre-clinical combination studies with each of our clinical candidates in specific genetically defined tumors. These data point us towards the potential use of our therapeutic candidates in combination treatment settings. Additionally, we are pleased to present data at ASH highlighting the opportunity to pursue a second genetically defined cancer, MLL-PTD, with EPZ-5676. MLL-PTD represents a distinct genetically defined acute leukemia in addition to our current clinical focus on MLL-r."

EPZ-5676, an inhibitor of the histone methyltransferase (HMT) DOT1L, is being developed as a treatment for patients with acute leukemias with rearrangements of the MLL gene (MLL-r). In the fourth quarter of 2013, Epizyme plans to announce top-line dose escalation data from the ongoing Phase 1 clinical study and, based on this data, initiate an expansion cohort stage that will be limited to patients with MLL-r.

EPZ-6438 is an inhibitor of the HMT EZH2 being developed as a tr
'/>"/>

SOURCE Epizyme, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Epizyme, Inc. Files Registration Statement for Proposed Initial Public Offering
2. Epizyme, Inc. Announces Pricing of Initial Public Offering
3. Epizyme, Inc. to Webcast Conference Call Discussing Second Quarter 2013 Financial Results on July 31, 2013
4. Epizyme, Inc. to Present at Wedbush Securities Life Sciences Management Access Conference in August
5. Epizyme, Inc. to Present at Upcoming Conferences in September
6. Epizyme, Inc. Granted Notice of Allowance of Patent for EPZ-5676
7. Epizyme, Inc. to Present at Upcoming Conferences in November
8. Report Presents a Framework for Successful New Oncology Product Launches in the Pharmaceutical Sector
9. Latest Findings in Breastfeeding Science Presented at Medelas 7th International Breastfeeding and Lactation Symposium
10. Auxilium Pharmaceuticals to Present at the Deutsche Bank 37th Annual Healthcare Conference
11. Enox Biopharma, Inc. To Present Today At IN3 Medical Device 360 Conference In London
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... Tianyin Pharmaceutical Inc. (NYSE Amex: TPI ... patented biopharmaceutical, modernized traditional Chinese medicine (mTCM), branded ... preliminary financial results for the first quarter of ... Ended September 30, 2014 Financial Highlights: , ... in 1Q14 with gross margins improved to 52% ...
(Date:12/24/2014)... , Dec. 24, 2014  Conkwest, Inc., the ... the proprietary Natural Killer (NK) cell-line platform, Neukoplast® ... Patrick Soon-Shiong , NantWorks founder, physician scientist ... agreement to purchase approximately $48 million of the ... the investment, he will be named Co-Chairman of ...
(Date:12/24/2014)... 23, 2014 PuraMed BioScience®, Inc., (OTC Pink: ... medicinal and healthcare products, announced it received the initial ... hemp-based, advanced headache relief product, for planned distribution to ... Colorado , Washington State , ... the MigraPure H Advanced headache relief gel formulation completed, ...
Breaking Medicine Technology:TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 2TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 3TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 4TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 5TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 6TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 7TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 8TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 9TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 10TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 11TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 12Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 2Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 3Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 4Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 5PuraMed BioScience Nears Final Stages Needed for Distribution of MigraPure H 2PuraMed BioScience Nears Final Stages Needed for Distribution of MigraPure H 3
... NEW YORK, Feb. 9, 2011 Reportlinker.com announces ... in its catalogue: European Markets ... http://www.reportlinker.com/p0377966/European-Markets-for-Spinal-Implants-and-VCF-2011.html iData,s comprehensive ... report is the industry leading research report for ...
... 2011 Rigel Pharmaceuticals, Inc. (Nasdaq: RIGL ... chairman and chief executive officer, is scheduled to participate ... week. Details of the events are as follows:Tuesday, February ... Investor ConferencePanel Topic:  "Rheumatoid Arthritis: the Real Joint Problem"Tuesday, ...
Cached Medicine Technology:Reportlinker Adds European Markets for Spinal Implants and VCF 2011 2Rigel Announces Participation at Two Investor Conferences 2
(Date:12/24/2014)... News) -- Adults who experienced childhood abuse or ... suggests a study published online Dec. 24 in ... can have long-lasting effects, like associated medical and ... Dawn Buse, director of behavioral medicine at Montefiore ... a journal news release. "When managing patients ...
(Date:12/24/2014)... Tara Haelle HealthDay Reporter ... Teens are more likely to start smoking or drinking ... disorder (ADHD) or conduct disorder, new research suggests. ... about the risk of substance use as [these] children ... director at Cincinnati Pediatric Research Group, which is part ...
(Date:12/24/2014)... HealthDay Reporter TUESDAY, Dec. 23, 2014 ... (ADA) call for giving the cholesterol-lowering drugs known as statins ... These new standards bring the association in line with ... also recommend giving low- or high-dose statins to all people ... "We agree that the decision to start a statin should ...
(Date:12/24/2014)... 2014 For chic ladies, new fashionable outfits ... part of their Holiday Wish List, Angeldress.co.uk has ... ways to accent ladies’ holiday wardrobe by launching a promotion ... all over the discount of 80% off, like a cheap ... ship. The company’s chic wedding dresses are among the hottest ...
(Date:12/24/2014)... December 24, 2014 Dr. Svetlana Gomer, ... across the nation gathered with US Marines on November ... raise funds for the Toys for Tots Literacy Program. ... thousands of new books and audio books for the ... underprivileged children this Christmas. It represents another major strike ...
Breaking Medicine News(10 mins):Health News:Abuse in Childhood Tied to Migraines in Adulthood 2Health News:ADHD May Raise Teens' Odds for Smoking, Drinking 2Health News:ADHD May Raise Teens' Odds for Smoking, Drinking 3Health News:Nearly All Diabetics Should Be on Cholesterol-Lowering Drugs: Experts 2Health News:Nearly All Diabetics Should Be on Cholesterol-Lowering Drugs: Experts 3Health News:Angeldress.co.uk Starts Its Big Sales by Offering Various Kinds of Cheap Clothes and Fashion Accessories 2Health News:Dr. Svetlana Gomer, MGS Tewksbury Dental and Other Dentists Working With the U.S. Marines Strike Again In the Battle Against Illiteracy 2Health News:Dr. Svetlana Gomer, MGS Tewksbury Dental and Other Dentists Working With the U.S. Marines Strike Again In the Battle Against Illiteracy 3
... Anaemia, a killer horse disease, is not about to deter ... no bones that the show will go on// , despite ... ,Nine horses have been fatally hit by EIA, ... positive for the disease. Show director Gerry McAuliffe confirmed that ...
... years, 50 million American women will be in menopause. ... use of synthetic hormone replacement// therapy (HRT) in a ... left many women and physicians uncertain about the safety ... (“natural”) hormone replacement therapy (nBHRT) has been proposed by ...
... of them women, were taken ill after inhaling fumes ... Bolangir district// , official said Thursday. ,The agricultural ... a field at Khairmal village, some 15 km from ... medical officer Sarada Prasad Mishra told IANS on phone. ...
... new study in patients with type 2 diabetes demonstrate ... chromium picolinate// , in combination with a common oral ... than the oral anti-diabetic agent alone. ,The ... (PBRC) and the University of Vermont College of Medicine, ...
... The tragic drug trial that left six volunteers seriously ill ... University researchers are collaborating with scientists from the drugs firm ... patients are exposed to a tiny amount of the drug ... in the earlier drug trial. , ,"We can monitor ...
... Economy has shown that in utero health has a great ... study is important because of its ramifications on health programs ... that can have far reaching impact in adulthood, much more ... purposes is that whereas heredity is immutable, congenital characteristics are ...
Cached Medicine News:Health News:Bio-Identical Hormone Replacement Therapy 2Health News:Bio-Identical Hormone Replacement Therapy 3Health News:Supplementation with Chromium Picolinate Improves Glycemic Control 2Health News:Personal Growth and Success Dependent on Prenatal Health 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: