Navigation Links
Epizyme, Inc. Granted Notice of Allowance of Patent for EPZ-5676
Date:9/3/2013

CAMBRIDGE, Mass., Sept. 3, 2013 /PRNewswire-USNewswire/ -- Epizyme, Inc., (NASDAQ: EPZM) a clinical stage biopharmaceutical company creating innovative personalized therapeutics for patients with genetically defined cancers, announced today that the U.S. Patent and Trademark Office (USPTO) has issued a Notice of Allowance for U.S. Patent Application No. 13/310,157 "SUBSTITUTED PURINE AND 7-DEAZAPURINE COMPOUNDS" with claims covering the novel compound EPZ-5676. Epizyme's EPZ-5676 is a small molecule DOT1L inhibitor designed to treat acute leukemias in which the MLL gene is rearranged due to a chromosomal translocation (MLL-r).

About EPZ-5676

Epizyme is developing EPZ-5676, a small molecule inhibitor of DOT1L created with Epizyme's proprietary product platform, for the treatment of acute leukemias in which the MLL gene is rearranged due to a chromosomal translocation (MLL-r). Due to the translocation, DOT1L is recruited to specific locations in the chromosome where it would not normally be present. As a result, DOT1L causes inappropriate methylation at these locations, which results in the increased expression of genes causing leukemia.

In September 2012, Epizyme initiated a Phase 1 clinical trial for EPZ-5676. The company believes EPZ-5676 is the first HMTi to enter human clinical development. As of August 2013, this program is in the dose escalation phase and is expected to initiate an expansion phase in the second half of 2013 that will exclusively enroll MLL-r patients.

Epizyme retains all U.S. rights to EPZ-5676 and has granted Celgene an exclusive license to EPZ-5676 outside of the United States. Epizyme has partnered with Abbott to develop a companion diagnostic to identify MLL-r patients. Additional information about these partnerships may be found
'/>"/>

SOURCE Epizyme, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Epizyme, Inc. to Present at Upcoming Conferences in September
2. Epizyme, Inc. to Present at Wedbush Securities Life Sciences Management Access Conference in August
3. Epizyme, Inc. to Webcast Conference Call Discussing Second Quarter 2013 Financial Results on July 31, 2013
4. Epizyme, Inc. Announces Pricing of Initial Public Offering
5. Epizyme, Inc. Files Registration Statement for Proposed Initial Public Offering
6. Oncos Therapeutics Granted Orphan Drug Designation for CGTG-102 in Soft Tissue Sarcoma (STS) by FDA and EMA
7. Trevena Granted Key Composition of Matter Patent for TRV027 in U.S.
8. CorMedix Granted Extension of NYSE MKT Listing
9. QRxPharma Granted US Patent On Hybrid Opioids
10. Mapi Pharma Granted United States Patent Covering Glatiramer Depot for Multiple Sclerosis
11. Omeros Ophthalmology Product OMS302 Granted Eligibility for European Centralized Review
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/26/2014)... 26, 2014 Research and Markets ... Meter Industry Report 2014 " report to their ... Report 2014 is a professional and in-depth study on ... The report provides a basic overview of ... structure. The glucose meter market analysis is provided for ...
(Date:8/26/2014)... Aug. 26, 2014   Quanta Aesthetic Lasers , the ... America , expands the offerings in their robust product ... is now available for shipping to medical spas, clinics, and ... The QuantaShape is manufactured in the Chianti hills ... Project .  The device was previously sold as both the ...
(Date:8/26/2014)... Aug. 26, 2014 Research and ... "Global Veterinary Diagnostics Market 2014-2018" report ... include various tests, which are used to detect ... and biomedical researchers are mainly availing these diagnostic ... Acid/Ribonucleic Acid testing), immunodiagnostics, clinical chemistry, and hematology. ...
Breaking Medicine Technology:Global Glucose Meter Industry Report 2014 2Global Glucose Meter Industry Report 2014 3Another Italian Beauty Joins the Quanta Aesthetic Lasers Lineup 2Global Veterinary Diagnostics Market 2014-2018: Key Vendors are Abaxis, Heska, IDEXX Laboratories, Mindray Medical, VCA Antech and Zoetis 2Global Veterinary Diagnostics Market 2014-2018: Key Vendors are Abaxis, Heska, IDEXX Laboratories, Mindray Medical, VCA Antech and Zoetis 3
... (Nasdaq: CADX ), a biopharmaceutical company focused ... use in the hospital setting, today reported financial ... September 30, 2008., The company also provided ... two Phase III product candidates -- Acetavance(TM), an,intravenous ...
... Denmark, November 6 Bavarian,Nordic has completed a clinical ... in HIV infected subjects that confirms the excellent,safety profile ... report,of this study will be submitted to the FDA ... under the RFP-3 contract. The clinical safety,report constitutes a ...
Cached Medicine Technology:Cadence Pharmaceuticals Reports Third Quarter 2008 Financial Results and Provides Clinical Development Programs Update 2Cadence Pharmaceuticals Reports Third Quarter 2008 Financial Results and Provides Clinical Development Programs Update 3Cadence Pharmaceuticals Reports Third Quarter 2008 Financial Results and Provides Clinical Development Programs Update 4Cadence Pharmaceuticals Reports Third Quarter 2008 Financial Results and Provides Clinical Development Programs Update 5Cadence Pharmaceuticals Reports Third Quarter 2008 Financial Results and Provides Clinical Development Programs Update 6Cadence Pharmaceuticals Reports Third Quarter 2008 Financial Results and Provides Clinical Development Programs Update 7Cadence Pharmaceuticals Reports Third Quarter 2008 Financial Results and Provides Clinical Development Programs Update 8Bavarian Nordic Reports Successful Safety Data From Phase II Study With IMVAMUNE(R) 2
(Date:8/27/2014)... 2014 Top10BestSEOHosting.com compares many popular ... are the most recommended suppliers for webmasters who ... , “GreenGeeks and GoDaddy provide stellar hosting products ... they have managed to provide a wide range ... ease of use that helps diminish the inherent ...
(Date:8/27/2014)... and Ontario, Canada (PRWEB) August 27, 2014 ... through a huge transformation as was revealed in a ... 2014 survey were not just surprising but astonishing as ... survey carried out online interviewed existing members on the ... Facebook. , According to Kaly, 10yeargap marketing department manager," ...
(Date:8/27/2014)... (PRWEB) August 27, 2014 Discover Leadership ... personal and corporate transformation through their comprehensive leadership programs. ... Moses has unparalleled experience in the realm of outcome-focused ... this expertise in a new webinar series titled, “A ... Seller.” The first of this two part webinar is ...
(Date:8/27/2014)... NY (PRWEB) August 27, 2014 Overcoming a ... he finally found his niche. The Women’s Radio Network, WRNW1, ... for his continued support and dedication to the WRNW1 family. ... able to have such a positive atmosphere.” After KC Armstrong ... Sirius XM of the Howard Stern show, “Howard 100 News,” ...
(Date:8/27/2014)... 2014 Casey Diekman, assistant professor of ... is helping to gain greater insight into the biological ... Evolution has harmonized the behavior of humans and all ... the cycle of light and dark experienced each day ... hormone production related to natural patterns of sleep/wake behavior ...
Breaking Medicine News(10 mins):Health News:Excellent Hosting Suppliers Recommended By Top10BestSEOHosting.com 2Health News:Survey Reveals Younger Women Dating Older Men 2Health News:Survey Reveals Younger Women Dating Older Men 3Health News:Barb Moses, Vice President of Discover Leadership Training, Announces New Webinar Titled, “A Women’s Guide to Making Her Life Story a Bestseller” 2Health News:The Women's Radio Network, WRNW1, Signs KC Armstrong to a Multi-Million Dollar Contract 2Health News:NJIT Researcher Receives New NSF Funding to Study Fundamental Rhythms of Life 2Health News:NJIT Researcher Receives New NSF Funding to Study Fundamental Rhythms of Life 3Health News:NJIT Researcher Receives New NSF Funding to Study Fundamental Rhythms of Life 4
... bars are completely interchangeable in the Medifast 5 & ... Medifast, Inc.,(NYSE: MED ), a leading portion-controlled weight-loss ... featuring a great crunchy,taste and a new formula that ... bar flavors include Chocolate Mint Crunch,Peanut Butter Crunch, and ...
... pathway may affect esophageal cancer risk, a dangerous and rapidly ... The University of Texas M. D. Anderson Cancer Center. , ... at the association between variations in genes related to microRNAs ... of Cancer Prevention Research , a journal of the ...
... Health Care recognizes health care ... Award, OAKLAND, Calif., Nov. 5 The California ... the "Director,s,Right Care Initiative Award" for its outstanding work ... presentation of the award and is,part of the DMHC,s ...
... the key factors that health professionals need to be aware ... Researchers from the University of Sheffield, UK, found considerable differences ... 16 viewed a series of sexual scenarios. , "The ... likely to see their partner,s point of view and were ...
... employers cost-effective, turnkey solution,to improve employee health., ... now have a,cost-effective solution to reduce employee ... competitive by attracting and retaining talent. Today,HealthFitness ... - a powerful combination of its eHealth ...
... CITY, China, Nov. 5 /Xinhua-PRNewswire-FirstCall/,-- China Pharma Holdings, ... manufactures, and markets generic and branded,bio-pharmaceutical products in ... 2008 results on Friday, November 7, 2008. In ... at 10:00 a.m. EST on Friday,November 7, 2008 ...
Cached Medicine News:Health News:Medifast Adds New Crunchy Bars to Product Line 2Health News:Gene variations alter risk of esophageal cancer 2Health News:Kaiser Permanente Honored for Success in Diabetes and Heart Disease Prevention 2Health News:Kaiser Permanente Honored for Success in Diabetes and Heart Disease Prevention 3Health News:Kaiser Permanente Honored for Success in Diabetes and Heart Disease Prevention 4Health News:Alcohol advice needs to play a greater role in sex education for teenagers 2Health News:Alcohol advice needs to play a greater role in sex education for teenagers 3Health News:HealthFitness Launches New Preventive Health Solution for Small Employers 2Health News:HealthFitness Launches New Preventive Health Solution for Small Employers 3Health News:China Pharma Holdings, Inc. to Host Third Quarter 2008 Earnings Conference Call at 10 a.m. EST Friday November 7, 2008 2Health News:China Pharma Holdings, Inc. to Host Third Quarter 2008 Earnings Conference Call at 10 a.m. EST Friday November 7, 2008 3
Inquire...
... Reference Series 2000 Pipette is a synonym ... compact and robust design, and superior operating ... to operate the measuring stroke and blow-out ... features:Eppendorf "pipette/tip" system ensures utmost accuracy and ...
... The Eppendorf Reference Series 2000 Pipette ... smooth stroke, a compact and robust design, ... button is used to operate the measuring ... the tip. Product features:Eppendorf "pipette/tip" system ensures ...
... Reference Series 2000 Pipette is a synonym ... compact and robust design, and superior operating ... to operate the measuring stroke and blow-out ... features:Eppendorf "pipette/tip" system ensures utmost accuracy and ...
Medicine Products: