Date:8/9/2012

– Leading Players 539.1 Merck & Co., Inc. 549.1.1 Business Overview 549.1.2 Epigenetic Portfolio 549.2 Novartis AG 559.2.1 Business Overview 559.2.2 Epigenetic Portfolio 559.3 Syndax Pharmaceuticals, Inc. 559.3.1 Business Overview 559.3.2 Epigenetic Portfolio 569.4 4SC AG 569.4.1 Business Overview 569.4.2 Epigenetic Portfolio 569.5 GlaxoSmithKline Plc 579.5.1 Business Overview 579.5.2 Deals 579.6 Celgene Corporation 579.6.1 Business Overview 579.6.2 Epigenetic Portfolio 579.7 MethylGene Inc. 589.7.1 Business Overview 589.7.2 Epigenetic Portfolio 589.8 Pharmacyclics, Inc. 589.8.1 Business Overview 589.8.2 Epigenetic Portfolio 589.9 TopoTarget A/S 599.9.1 Business Overview 599.9.2 Epigenetic Portfolio 599.10 S*BIO Pte Ltd 599.10.1 Business Overview 599.10.2 Epigenetic Portfolio 599.11 Curis, Inc. 609.11.1 Business Overview 609.11.2 Epigenetic Portfolio 6010 Epigenetics R&D Pipeline – Strategic Consolidation 6110.1 M&A Deals 6210.1.1 Celgene Corporation Completes Acquisition of Gloucester Pharmaceuticals 6210.1.2 Celgene Corporation Acquires the Rights to Vidaza through the Acquisition of Pharmion Corporation 6210.1.3 Eisai Co., Ltd Completes Acquisition of MGI Pharma Inc. 6210.1.4 4SC AG Successfully Completes Transaction of Nycomed Oncology Projects 6210.1.5 Astex Pharmaceuticals Enters into an Asset Transfer Agreement with GlaxoSmithKline 6210.2 Licensing Deals 6310.2.1 Celleron Therapeutics Enters into Licensing Agreement with AstraZeneca Plc 6310.2.2 Spectrum Pharmaceuticals Enters into Licensing Agreement with TopoTarget A/S 6310.2.3 CellCentric Enters into Licensing Agreement with Takeda Pharma 6310.2.4 Cellzome Announces Second Major Strategic Drug Discovery Alliance with GlaxoSmithKline in Inflammatory Diseases 6410.2.5 4SC Enters into Licensing Agreement with Yakult Honsha for Japan for Resminostat 6410.3 Co-development Deals 6410.3.1 Pharmacyclics Enters into Collaboration with Les Laboratoires Servier 6410.3.2 Curis Enters into Co-d
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