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EpiCept Announces Successful Completion of Enrollment for Phase I Trial of EPC2407
Date:10/7/2007

ug. Results from the study will also help characterize the pharmacodynamic effects on tumor blood flow and potentially identify early signs of objective anti-tumor response as measured by CT scans, MRI or PET, in advanced cancer patients with well vascularized solid tumors.

Mr. Talley continued, "Our advancement of EPC2407 and the regulatory progress we announced earlier this month on Ceplene(TM), demonstrates the opportunities inherent in our pursuit of both early- and late-stage cancer programs, and, when combined with our pipeline of pain candidates, illustrates the long-term potential offered by our company."

About EPC2407

EPC2407 was discovered through EpiCept's Anti-cancer Screening Apoptosis Program (ASAP), a proprietary technology used to rapidly test and generate product candidates for cancer. EPC2407 has shown promising vascular targeting activity with nanomolar potencies of anti-tumor activity in pre-clinical in vitro and in vivo studies. The molecule has been shown to induce tumor cell apoptosis and selectively inhibit growth of proliferating cell lines, including multi-drug resistant cell lines. Murine models of human tumor xenografts demonstrated EPC2407 inhibits growth of established tumors of a number of different cancer types more effectively than the other VDAs tested and was synergistic when used in combination with anticancer agents, such as Cisplatin. EPC2407 is one of two VDA compounds currently in clinical trials discovered through EpiCept's ASAP technology. The second compound, Azixa(TM), is part of the EP90745 series of apoptosis inducers, which was licensed by EpiCept to Myriad Genetics, Inc. as part of an exclusive, worldwide development and commercialization agreement.

About EpiCept's ASAP Technology

Cancer cells often exhibit unchecked growth caused by the disabling or absence of the natural process of programmed cell death, which is called apoptosis. Apoptosis is normally triggered to destroy a cell from wi
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SOURCE EpiCept Corporation
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