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EpiCept Announces Successful Completion of Enrollment for Phase I Trial of EPC2407
Date:10/7/2007

Follow up Combination Therapy Trial planned for 2008

TARRYTOWN, N.Y., Oct. 8 /PRNewswire-FirstCall/ -- EpiCept Corporation (Nasdaq and OMX Nordic Exchange: EPCT) today announced that it has completed its Phase I clinical trial for EPC2407. The trial has met all of its objectives. EPC2407 is EpiCept's novel small molecule vascular disruption agent (VDA) and apoptosis inducer for the treatment of patients with advanced solid tumors and lymphomas.

(Logo: http://www.newscom.com/cgi-bin/prnh/20020513/NYM112LOGO )

EpiCept successfully identified the maximum tolerated dose of EPC2407 in the Phase I study. The maximum tolerated dose was well below the dose which produced the expected toxicity based on preclinical studies at higher doses. EPC2407 was administered as a single agent in increasing doses to small cohorts of patients with advanced solid tumors. A total of seventeen patients were enrolled in the study. The drug was tested in a variety of cancer types including melanoma, prostate, lung, breast, colon, and pancreatic cancers. The study, which was initiated in December 2006, was conducted at three cancer centers in the U.S.

"We are pleased that this milestone has been reached," stated Jack Talley, President and Chief Executive Officer. "We are now in the process of meeting with our advisors to move forward with a Phase Ib combination trial for the drug with other chemotherapeutic agents. Preclinical data in mouse xenograft models indicate there is either additive or synergistic activity when EPC2407 is used in combination with other cancer therapeutic agents including Cisplatin, Sutent(R)* and Avastin(R)*. We anticipate being able to initiate this combination trial in early 2008."

In addition to determining the maximum tolerated dosage of the EPC2407, the primary objective of the study was to determine the pharmacokinetic profile of the dr
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SOURCE EpiCept Corporation
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