EntreMed's ENMD-2076 Active in Solid and Hematologic... (nts for ovarian cancer patients who have...)

EntreMed's ENMD-2076 Active in Solid and Hematological Cancers

Date:11/16/2009

nts for ovarian cancer patients who have failed current standard of care.

These clinical data combined with the known mechanisms of ENMD-2076, including its antiangiogenic properties and activity against several targets important in the pathogenesis of ovarian cancer, support the selection of this indication to begin the Phase 2 program. EntreMed has received orphan drug designation for the use of ENMD-2076 in ovarian cancer patients and the Phase 2 study is expected to commence in the second quarter of 2010.

EntreMed Vice President and Chief Medical Officer, Carolyn F. Sidor, MD, MBA commented, "Although the leukemia study remains ongoing, data so far are very encouraging. ENMD-2076 alone was able to induce remission in an acute leukemia patient with a Flt-3 mutation. Additionally, some patients without this mutation achieved significant hematological improvements with reductions in blast percentages and/or the need for transfusions. It is possible that some of ENMD-2076's targets other than Flt-3 play a role in its activity and this is under active investigation. We are expanding the AML study to include additional patients that may benefit from ENMD-2076 therapy."

Dr. Sidor continued, "We are pleased to have selected a Phase 2 indication as it represents an important next step in advancing our clinical program for ENMD-2076. As reported earlier this year, ovarian cancer patients participating in the Phase 1 study in solid tumors were among those who demonstrated marked clinical benefit from ENMD-2076 administered orally as a single agent. We anticipate commencement of a Phase 2 study that will further define the activity of ENMD-2076 in relapsed or refractory ovarian cancer patients. We will continue to determine other potential uses for ENMD-2076 in cancer therapy by evaluating the results from our solid tumor Phase 1 study. Clinical data presented to date support the compound's activity in a variety of solid and hemat
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