Navigation Links
EntreMed's ENMD-2076 Active in Solid and Hematological Cancers
Date:11/16/2009

ROCKVILLE, Md., Nov. 16 /PRNewswire-FirstCall/ -- EntreMed, Inc. ( ENMD), a clinical-stage pharmaceutical company developing therapeutics for the treatment of cancer today announced the presentation of data for the Phase 1 study for its Aurora A/angiogenic kinase inhibitor, ENMD-2076, in leukemia patients. The Company also announced that it has selected ovarian cancer as an initial Phase 2 indication.

Phase 1 Leukemia Data

Initial data for the Phase 1 clinical study with ENMD-2076 in patients with relapsed or refractory acute myeloid leukemia (AML) were presented by principal investigator, Dr. Karen Yee, at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics being held this week in Boston, Massachusetts. Early results for the study in hematological cancers demonstrated that ENMD-2076, administered orally as a single agent, was well tolerated. Data for 15 evaluable patients showed that one patient achieved a CRi (complete remission with incomplete hematological recovery) and two patients achieved a morphologic leukemia-free state (MLFS). Three additional patients experienced 11%, 14%, and 65% reductions in marrow blast count. The AML study continues to enroll patients and pharmacodynamic and pharmacokinetic activity is being monitored.

Ovarian Cancer - Initial Phase 2 Indication

While early Phase 1 data from the leukemia study are encouraging, the Company has selected ovarian cancer as its initial Phase 2 indication. This decision is supported by data from the ongoing Phase 1 study with ENMD-2076 in patients with solid tumors where of the 20 ovarian cancer patients, tumor and tumor marker responses were demonstrated in 45% of patients. In addition, another 15% have shown clinical benefit including reductions in tumor size, improvement in symptoms, or both. The decision is further supported by robust preclinical data and the need for additional active age
'/>"/>

SOURCE EntreMed, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Entremed Presents Results of ENMD-2076 Phase 1 Study in Advanced Cancer Patients
2. EntreMed Presents Initial Clinical Results for ENMD-2076
3. EntreMed to Highlight ENMD-2076 Kinase Inhibitor at 2008 AACR Annual Meeting
4. EntreMed Achieves a Key Milestone Through Initiation of ENMD-2076 Clinical Program
5. Glamour Magazine Woman of the Year and MISSION Skincare Co-Founder, Serena Williams, Teams Up with CVS/pharmacy to Launch National Active Lifestyle Skincare Destinations
6. Trana Discovery and Southern Research Institute Find Bioactive HIV Antiviral Compounds
7. Accurays Treatment Planning Service Active at 20 Percent of U.S. CyberKnife Centers
8. MolSofts New Technology Brings Online Publications to Life in Fully Interactive 3D
9. Medcos 2010 Medicare Prescription Drug Plan Helps People Take an Active Part in Lowering Prescription Costs
10. Tata Interactive Systems Partners With Bersin & Associates for Exclusive Executive Learning Forum - TLF 2009
11. Alba Therapeutics Announces Enrollment of Its First European Patient in Global Phase IIb Study of Larazotide Acetate for Treatment of Active Celiac Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2015)... -- Click here for additional information on the earnings ... DPLO ), the nation,s largest independent specialty pharmacy, announced financial ... All comparisons, unless otherwise noted, are to the quarter or ... 2014 Highlights include: , Revenue of $612 million, ... 208,000, an increase of 11% , Gross margin of ...
(Date:3/2/2015)... 2015 BD (Becton, Dickinson and Company) (NYSE: ... company, today announced the acquisition of CRISI Medical Systems, ... company dedicated to improving the safety and delivery of ... helping address preventable medication errors and improve care delivery ... exclusive partnership in June 2013 to jointly develop the ...
(Date:3/2/2015)... Biomedical, Inc., a leading processor of human tissue, synthetics, ... it hired Lou Barnes as President and ... formed UMTB Biomedical as a wholly-owned subsidiary to acquire ... 2014. UMTB is the oldest tissue bank in the ... veteran of the tissue banking industry, having most recently ...
Breaking Medicine Technology:Diplomat Announces 4th Quarter and 2014 Year End Financial Results; Provides Initial 2015 Guidance 2Diplomat Announces 4th Quarter and 2014 Year End Financial Results; Provides Initial 2015 Guidance 3Diplomat Announces 4th Quarter and 2014 Year End Financial Results; Provides Initial 2015 Guidance 4Diplomat Announces 4th Quarter and 2014 Year End Financial Results; Provides Initial 2015 Guidance 5Diplomat Announces 4th Quarter and 2014 Year End Financial Results; Provides Initial 2015 Guidance 6Diplomat Announces 4th Quarter and 2014 Year End Financial Results; Provides Initial 2015 Guidance 7Diplomat Announces 4th Quarter and 2014 Year End Financial Results; Provides Initial 2015 Guidance 8Diplomat Announces 4th Quarter and 2014 Year End Financial Results; Provides Initial 2015 Guidance 9Diplomat Announces 4th Quarter and 2014 Year End Financial Results; Provides Initial 2015 Guidance 10Diplomat Announces 4th Quarter and 2014 Year End Financial Results; Provides Initial 2015 Guidance 11Diplomat Announces 4th Quarter and 2014 Year End Financial Results; Provides Initial 2015 Guidance 12Diplomat Announces 4th Quarter and 2014 Year End Financial Results; Provides Initial 2015 Guidance 13Diplomat Announces 4th Quarter and 2014 Year End Financial Results; Provides Initial 2015 Guidance 14Diplomat Announces 4th Quarter and 2014 Year End Financial Results; Provides Initial 2015 Guidance 15Diplomat Announces 4th Quarter and 2014 Year End Financial Results; Provides Initial 2015 Guidance 16Diplomat Announces 4th Quarter and 2014 Year End Financial Results; Provides Initial 2015 Guidance 17Diplomat Announces 4th Quarter and 2014 Year End Financial Results; Provides Initial 2015 Guidance 18Diplomat Announces 4th Quarter and 2014 Year End Financial Results; Provides Initial 2015 Guidance 19Diplomat Announces 4th Quarter and 2014 Year End Financial Results; Provides Initial 2015 Guidance 20Diplomat Announces 4th Quarter and 2014 Year End Financial Results; Provides Initial 2015 Guidance 21BD Acquires CRISI Medical Systems 2BD Acquires CRISI Medical Systems 3Vivex Biomedical, Inc. Announces New Chief Operating Officer of Tissue Bank 2Vivex Biomedical, Inc. Announces New Chief Operating Officer of Tissue Bank 3
... , , ... FSE: HBP; OTCQX: HXBPF) reports that at its Annual General ... Board of Directors , All seven Board members ... constituted of: , ,Donald H. Segal, Chairman of the Board ...
... , , RALEIGH, N.C., Dec. ... its Scientific Head of Infectious Diseases Carl Kraus, M.D., ... conference along with John Powers, M.D., Assistant Professor of ... regulatory environment considerations in anti-infective drug development. , Understanding ...
Cached Medicine Technology:Helix BioPharma Reports On 2009 Annual General Meeting 2Helix BioPharma Reports On 2009 Annual General Meeting 3PRA International Hosts an Infectious Diseases Audio Conference 2PRA International Hosts an Infectious Diseases Audio Conference 3
(Date:3/2/2015)... Calif. (PRWEB) March 02, 2015 ... (R-San Luis Obispo), in partnership with the California ... Rare Disorders (NORD), presented an Assembly resolution recognizing ... the families and healthcare professionals caring for millions ... CHI is a nonprofit, public policy research organization, ...
(Date:3/2/2015)... March 02, 2015 Cutler Integrative Medicine ... to the root, gives cutting-edge tips to bring about ... to renew the body by first cleaning house. ... medicine, “We are all Toxic.” Between environmental toxins like ... potential greatness, and our high stress levels, we all ...
(Date:3/2/2015)... 1% for the Planet , one of the ... 25 new business members at this year’s Expo West since ... for the Planet welcomes them and more, including Boulder Brands’ ... butter line. , Food - how we grow it, ... to be a complex environmental issue throughout the country and ...
(Date:3/2/2015)... March 02, 2015 Market Publishers Ltd ... worked out by Global Industry Analysts Inc and recently ... Market Research Report . Through 2018, the global radiation ... CAGR. The detailed research report suggests a holistic analysis ... therapy equipment as well as covers the top market ...
(Date:3/2/2015)... 2015 “ Wants and Needs ” ... AppWatch, which features the latest and coolest mobile applications ... a mobile technology expert and host of NewsWatch, conducted ... app helps people evaluate priorities. , Whether a person ... and Needs app. The app allows people to enter ...
Breaking Medicine News(10 mins):Health News:California Healthcare Institute Spotlights Impact of Rare Diseases with Assemblymember Katcho Achadjian 2Health News:California Healthcare Institute Spotlights Impact of Rare Diseases with Assemblymember Katcho Achadjian 3Health News:Skin and Wellness Power Couple give Quick Tips to Self-Renewal for Spring 2Health News:1% For the Planet Members Shine Light on Food as Environmental Issue at Expo West 2Health News:1% For the Planet Members Shine Light on Food as Environmental Issue at Expo West 3Health News:New Topical Research Reports Prepared by GIA Now Available at MarketPublishers.com 2Health News:New Topical Research Reports Prepared by GIA Now Available at MarketPublishers.com 3Health News:An Application to Evaluate Priorities Was Featured on NewsWatch Television on January 30, 2015 2
... Coalition of patients, practitioners and employers urges ... deployment of interoperable health,information technology, WASHINGTON, ... co-chaired by former Senator John Breaux and ... Eshoo,and Mike Rogers for introducing legislation that ...
... The Pennsylvania,Department of Health today is emphasizing ... for consumers not to eat Banquet brand and,store ... possible,Salmonella contamination., "Federal officials have already shared ... ensure Pennsylvanians are taking the,appropriate measures to protect ...
... Guttmacher,Institute,s latest report on world abortion rates is ... W. Mosher. The,study, just released today, argues that ... developing countries., Accurate numbers are impossible to ... illegal. Says Mosher: "Neither,Guttmacher nor anyone else knows ...
... have discovered a key protein that controls how stem ... move limbs, or smooth muscle cells that support blood ... Proceedings of the National Academy of Sciences (PNAS). ... of muscle types in the human fetus, but also ...
... Ohio, Oct. 10 PartsSource, the nation,s leading,supplier ... &,CEO, A. Ray Dalton has been selected as ... Business" award. This honor is given to,executives who ... new,businesses throughout their professional career. "I am ...
... ... geographically, WILMINGTON, N.C., Oct. 10 ... as senior vice,president of clinical operations for North America and Simon ... Colvin joins PPD from Eli Lilly and Company where he most ...
Cached Medicine News:Health News:Health IT Now! Coalition Applauds Representatives Eshoo and Rogers for Introducing Health IT Legislation 2Health News:Salmonella Outbreak Traced to Banquet and Store Brand Frozen Pot Pies 2Health News:PRI Criticizes Guttmacher Report 2Health News:Study reveals how stem cells decide to become either skeletal or smooth muscle 2Health News:Study reveals how stem cells decide to become either skeletal or smooth muscle 3Health News:Study reveals how stem cells decide to become either skeletal or smooth muscle 4Health News:Study reveals how stem cells decide to become either skeletal or smooth muscle 5Health News:PPD Names VPs for North America and Asia 2Health News:PPD Names VPs for North America and Asia 3
... glycol polymers that combine to form COSEAL Surgical ... to each other, as well as to tissue ... flexible, watertight seal that remains intact at the ... It is completely resorbed by the body within ...
... The Cool Line catheter is inserted ... resides in the superior vena cava. ... balloons which have sterile, temperature-controlled saline flowing ... exchange with the central circulation. The ...
...
...
Medicine Products: