EntreMed Receives New Patent for 2-Methoxyestradi... ( Patent Covers Comp...)

EntreMed Receives New Patent for 2-Methoxyestradiol Analogs

Date:6/11/2008

Patent Covers Compositions and Methods

ROCKVILLE, Md., June 11 /PRNewswire-FirstCall/ -- EntreMed, Inc. (Nasdaq: ENMD), a clinical-stage pharmaceutical company developing therapeutics for the treatment of cancer and inflammatory diseases, today announced the issuance of U.S. Patent No. 7,371,741 covering analogs of 2- methoxyestradiol (2ME2). The patent grants EntreMed composition-of-matter and method of use intellectual property protection through 2025 for analogs of 2ME2 in oncology and a broad range of non-oncology indications, including inflammatory and immune disorders, rheumatoid arthritis, and other diseases characterized by abnormal cell division (mitosis).

(Logo: http://www.newscom.com/cgi-bin/prnh/20010620/ENMDLOGO )

Analogs of 2ME2 have been developed by EntreMed to improve metabolic stability and retain or enhance antiproliferative and antiangiogenic properties. Preclinical results demonstrate that certain analogs of 2ME2 can attack tumors on multiple fronts -- directly by disrupting microtubules, an intracellular matrix necessary for the rapid division of cancer cells, through inhibition of mitosis and induction of apoptosis, and by blocking blood vessels that feed tumors (angiogenesis inhibition).

U.S. Patent No. 7,371,741 entitled "Estradiol derivatives and pharmaceutical compositions using same," covers analogs that have been modified at certain positions on the 2-methoxyestradiol structure, yet retain their ability to inhibit cell proliferation. In addition, the '741 patent claims methods for treating tumors with compounds having the claimed structural modifications of 2-methoxyestradiol. The '741 p
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