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EntreMed Presents MKC-1 and ENMD-1198 Preclinical Data at AACR Annual Meeting
Date:4/16/2008

s, suggests interaction with tubulin may be important for the modulation of oncogenic proteins by ENMD-1198. In summary, data demonstrate that ENMD-1198 resistant 1A9 cells may provide a useful tool for evaluating a pharmacogenomic profile that can be correlated with clinical benefit.

Dr. Bray commented on the presentations, "We continue to see encouraging potent preclinical antitumor activity with MKC-1 and ENMD-1198. Although both compounds are currently in multiple clinical trials in oncology, these robust preclinical data further support and strengthen our knowledge of their mechanisms of action. Development of MKC-1 and ENMD-1198 is in line with the Company's focus on orally available, small molecule drugs for the treatment of cancer and inflammatory diseases. MKC-1 is currently in multiple Phase 1 and 2 clinical trials and ENMD-1198 is in a Phase 1 study in advanced cancers. Additional clinical studies are planned for both compounds in 2008."

To view a copy of the poster presentations, visit Scientific Presentations under the Therapeutic Pathways section of the Company's web site at http://www.entremed.com.

About EntreMed

EntreMed, Inc. is a clinical-stage pharmaceutical company developing therapeutic candidates primarily for the treatment of cancer and inflammation. MKC-1 is currently in multiple Phase 2 clinical trials for cancer. MKC-1 is an oral cell-cycle regulator with activity against the mTOR pathway. ENMD-1198, a novel antimitotic agent, and ENMD-2076, a selective kinase inhibitor, are in Phase 1 studies in advanced cancers. The Company also has an approved IND application for Panzem(R) in rheumatoid arthritis. EntreMed's goal is to develop and commercialize new compounds based on the Company's expertise in angiogenesis, cell-cycle regulation and inflammation - processes vital to the treatment of cancer and other diseases, such as rheumatoid arthritis. Additional informati
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