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EntreMed Presents MKC-1 and ENMD-1198 Preclinical Data at AACR Annual Meeting
Date:4/16/2008

Compounds Demonstrate Potent Antitumor Activity in a Variety of Tumor Types

ROCKVILLE, Md., April 16 /PRNewswire-FirstCall/ -- EntreMed, Inc. (Nasdaq: ENMD), a clinical-stage pharmaceutical company developing therapeutics for the treatment of cancer and inflammatory diseases, today announced the presentation of preclinical results for two of its clinical stage compounds, MKC-1 and ENMD-1198. Presentations were given by EntreMed scientists during two poster sessions at the American Association for Cancer Research (AACR) Annual Meeting being held this week in San Diego, California.

(Logo: http://www.newscom.com/cgi-bin/prnh/20010620/ENMDLOGO )

MKC-1 administered in combination with paclitaxel in a preclinical, orthotopic breast tumor model demonstrated synergistic tumor inhibition. The combination of MKC-1 and paclitaxel, but neither agent alone, demonstrated tumor regression of the bulky breast cell line tumors grown in this model. In addition, the combination decreased angiogenesis and proliferation, and increased apoptosis as early as 4 days post treatment. Treatment with the combination also decreased the oncogenic proteins HIF-1alpha, pAKT, and pS6 ribosomal proteins.

In a second presentation, treatment of the 1A9 human ovarian carcinoma cell line with ENMD-1198 induced cell cycle arrest and decreased levels of the oncogenic transcription factor proteins HIF-1alpha, pSTAT3, and pNFkappaB. Treatment with ENMD-1198 also downregulates expression of several tubulin isotypes in 1A9 cells, but not in ENMD-1198-resistant (1A9-1198R) cells. This, combined with the relative lack of inhibition of oncogenic proteins observed in 1A9-1198R cell
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SOURCE EntreMed, Inc.
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