EntreMed Presents MKC-1 Phase 2 Data at American Society of Clinical Oncology Annu... ( Antitumor Activity Demonstrated i...)

EntreMed Presents MKC-1 Phase 2 Data at American Society of Clinical Oncology Annual Meeting

Date:6/3/2008

Antitumor Activity Demonstrated in Metastatic Breast Cancer Patients

ROCKVILLE, Md., June 3 /PRNewswire-FirstCall/ -- EntreMed, Inc. (Nasdaq: ENMD), a clinical-stage pharmaceutical company developing therapeutics for the treatment of cancer and inflammatory diseases, today announced the presentation of clinical data for the MKC-1 Phase 2 study in patients with metastatic breast cancer. The data were presented by Bryan P. Schneider, M.D., Assistant Professor, Department of Medicine, Indiana University, during the Breast Cancer -- Metastatic session at the American Society of Clinical Oncology Annual Meeting being held this week in Chicago, Illinois.

(Logo: http://www.newscom.com/cgi-bin/prnh/20010620/ENMDLOGO )

For this Phase 2 single agent, open label study, a total of 65 patients who had previously received at least one anthracycline and taxane therapy were enrolled. 55 patients were evaluable for tumor response. Of the evaluable patients, the antitumor activity observed with MKC-1 included 3 patients who had responses and 5 patients with stable disease lasting more than four months.

MKC-1 is a novel, orally-active cell cycle inhibitor with in vitro and in vivo efficacy against a broad range of human solid tumor cell lines, including multi-drug resistant cell lines. Data from previous studies with MKC-1 demonstrate broad-acting antitumor effects, showing tumor growth inhibition or regression in multiple preclinical models, including paclitaxel-resistant models. To date, MKC-1 has been evaluated in over 400 patients in multiple Phase 1 and 2 clinical trials.

Carolyn F. Sidor, MD, MBA, EntreMed Vice President and Chief Medic
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