Navigation Links
EntreMed Presents Initial Clinical Results for ENMD-2076
Date:2/9/2009

ined by reduction in tumor markers in ovarian and colorectal cancer patients. Dose escalation continues to determine the primary endpoints of the study, safety, pharmacokinetics and a Phase 2 dose.

During the symposium, EntreMed's Senior Director, Translational Research, William E. Fogler, Ph.D., presented results from a preclinical evaluation of ENMD-2076 in combination with cisplatin in a multi-drug resistant, triple-negative human breast carcinoma model. Triple-negative breast cancer is a specific subtype of breast cancer that does not express estrogen receptor, progesterone receptor, or Her2 genes. This subtype is more aggressive and less responsive to standard treatment and is also associated with poorer patient prognosis. Data show the combination is well tolerated when using a maximally tolerated dose of cisplatin and a range of ENMD-2076 doses. Studies demonstrate a substantial dose-dependent antitumor combination effect as assessed by tumor regression. The enhanced antitumor activity observed with the combination of ENMD-2076 and cisplatin, over either agent alone, is correlated to biomarkers of angiogenesis, proliferation and apoptosis. These results provide a rationale for the clinical evaluation of ENMD-2076 in tumors responsive to platinum compounds, and particularly in triple-negative breast disease refractory to standard of care agents.

To further expand the clinical development of ENMD-2076, EntreMed has received a No Objection Letter (NOL) from the Therapeutic Products Directorate of Health Canada on its Clinical Trial Application to conduct a clinical study in Canada for ENMD-2076 in patients with hematological malignancies. A Canadian Clinical Trial Application (CTA) is similar to a United States Investigational New Drug (IND) application. The Company plans to commence a Phase 1 study in patients with relapsed or refractory leukemias in Canada later this year.

In addition, the U.S. Food a
'/>"/>

SOURCE EntreMed, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. EntreMed Presents Data for Phase 2 Study of MKC-1 in Metastatic Breast Cancer
2. EntreMed Raises $20 Million to Support Clinical Development Program
3. EntreMed Reports Phase 1 PK and Preclinical Efficacy Results for ENMD-1198
4. EntreMed Shows Increased Survival With MKC-1 in Preclinical Renal Cell Cancer Model
5. EntreMed Commences Phase 2 Study with MKC-1 in Pancreatic Cancer
6. EntreMed to Present at The New York Society of Security Analysts Industry Conference
7. EntreMed Commences Phase 2 Study With MKC-1 in Ovarian/Endometrial Cancers
8. EntreMed Commences Continuous Dosing Clinical Trial For MKC-1
9. EntreMed Achieves a Key Milestone Through Initiation of ENMD-2076 Clinical Program
10. EntreMed to Highlight ENMD-2076 Kinase Inhibitor at 2008 AACR Annual Meeting
11. EntreMed Presents MKC-1 and ENMD-1198 Preclinical Data at AACR Annual Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... BERWYN, Pa. , July 25, 2014  AMETEK, ... appointment of Kurtis L. Goos as Vice ... Engineered Materials, Interconnects and Packaging (EMIP) Division. ... has extensive general management and business development experience, especially ... to make important contributions to the continued growth and ...
(Date:7/25/2014)... July 25, 2014  Arena Pharmaceuticals, Inc. (NASDAQ: ... corporate update and report second quarter 2014 financial results ... August 1, 2014. That same day, Arena will host ... Time (5:30 a.m. Pacific Time). The ... domestic callers and 914.495.8552 for international callers. Please specify ...
(Date:7/24/2014)...  PTC Therapeutics, Inc. (NASDAQ: PTCT ) ... conference call to report its second quarter 2014 financial ... and outlook on Thursday, August 7, 2014 at 8:30 ... The call can be accessed by dialing ... prior to the start of the call and providing ...
Breaking Medicine Technology:AMETEK Names Kurtis L. Goos, Vice President & General Manager, Engineered Medical Components 2Arena Pharmaceuticals to Host Corporate Update and Financial Results Conference Call and Webcast on Friday, August 1 2Arena Pharmaceuticals to Host Corporate Update and Financial Results Conference Call and Webcast on Friday, August 1 3
... secret is finally reaching the east coast and all points ... health and beauty boutique named Endless Youth and Life is ... supplement is helping thousands of Americans shed excess abdominal fat ... Just a few capsules per day and their stomachs are ...
... Inc. (NASDAQ: IPHS ) today announced that its ... $0.25 per share of common stock.  The dividend will be ... of the close of business on October 14, 2011. ... American producer of specialty phosphate products, offering performance-critical ingredients with ...
Cached Medicine Technology:Beverly Hills Secret Now Helping People Across The Country 2
(Date:7/25/2014)... As reported by the Statesman Journal in ... (7/20), police in Salem, MA as well as several ... recent heroin epidemic that has taken many lives during the ... overdose case in which police were able to make two ... By pretending to be the victim and claiming to want ...
(Date:7/25/2014)... NY (PRWEB) July 25, 2014 ... prices across the board for the Guinness International Champions ... and Olympiacos FC at Soldier Field on Sunday, ... offering their customer appreciation promo/coupon/offer code SOCCER-2014 for added ... amazing year for diehard soccer fans in North America. ...
(Date:7/25/2014)... -- Seniors are more easily distracted during thinking and ... "Almost any type of memory test administered reveals ... on," study co-author Randi Martin, professor of psychology at ... However, Martin said, this study shows that "environmental interference" ... compared with younger adults. The study included 60 ...
(Date:7/25/2014)... UT (PRWEB) July 25, 2014 ... surfaces for the recent Nike National Invitational Tournament ... current United States Junior National Tournament (USJN) ... 25. , The flooring for these prestigious national tournaments ... than 300,000 square feet of playing surface at McCormick ...
(Date:7/25/2014)... Reproductive Science Center (RSC) of New England ... Lead Physician at RSC Rhode Island, received the distinguished ... fertility care and community outreach issued by Providence Business ... Awards ceremony held July 24th at Salve Regina University ... regarded, emerging leaders in their field were recognized by ...
Breaking Medicine News(10 mins):Health News:Multiple States Crack Down on Heroin Epidemic 2Health News:Liverpool FC vs. Olympiacos FC Tickets Soldier Field: Ticket Down Slashes Ticket Prices for Guinness International Champions Cup in Chicago on Sunday, July 27th 2Health News:Distractions Seem More Troublesome With Age 2Health News:Sport Court Provides All Sports Flooring for Basketball Events in Chicago and Washington D.C. 2Health News:Dr. Kerri Luzzo of the Reproductive Science Center of Providence Receives “40 Under Forty Award" for Outstanding Professional Accomplishments and Community Outreach 2
... the way the industry outsources its services by providing a backroom ... professionals and resellers. , ... Bohemia, NY (Vocus) April, ... specialized expertise and only generates a few cents in revenue? This ...
... over-the-counter melatonin reduces time to slumber , , FRIDAY, April ... treat sleep problems in children with autism, a small ... aged 2 to 15 years, with autism spectrum disorder, ... randomly selected to take melatonin or a placebo for ...
... MIAMI, April 17 Not since the United States ... such significant hardships to their health and well-being across ... wellness. Losing jobs at a rapid pace, people are ... of identity, security and status. Yet Miami,s St. ...
... events have led people to re-examine their lifestyles and ... that it is time to get to the basics ... to start their families now, instead of waiting for ... a growing number of couples who are consulting fertility ...
... DEBRECEN, Hungary, April 17 Bertalan Mesko, medical blogger ... with his readers. EchoJournal, a video site designed to ... by the editorial team of one of the most ... features familiar to users of other video sharing sites, ...
... experts say results from the small study are no reason ... -- Lower hormone levels in women who exercise regularly and ... a new study suggests. , But the muscle-mass differences between ... did not affect performance. , At this point, ...
Cached Medicine News:Health News:Penny Imaging Exchange, Inc. Outlines the Trend & Economics of Scanning Microfilm 2Health News:Penny Imaging Exchange, Inc. Outlines the Trend & Economics of Scanning Microfilm 3Health News:Melatonin May Ease Sleep Problems in Autistic Children 2Health News:Good News for Tough Times: Small, Private University Responds to Today's Economic Challenges 2Health News:Family Cocooning in the Face of Recession Leads to Expanded Business for Bay Area Fertility Doctor - Dr. Danielle Lane 2Health News:The Pill May Limit Muscle Gains in Women 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: