Navigation Links
EntreMed Commences Phase 2 Study With MKC-1 in Ovarian/Endometrial Cancers
Date:1/23/2008

e M-phase (mitosis) of the cell cycle, and induce apoptosis. Furthermore, MKC-1 inhibits the Akt-mTOR signaling pathways, which may occur through inhibition of the mTOR/rictor pathway. The Akt-mTOR pathway is the most frequently mutated pathway in human tumors and mutations have been shown to promote tumor progression and decrease survival in cancer patients."

Commencement of this Phase 2 multi-center study represents the continuation of our focus on the development of MKC-1 in diseases where, based on its mechanism of action, we would expect activity," commented Carolyn F. Sidor, M.D., M.B.A., EntreMed's Vice President and Chief Medical Officer. "We now have five clinical trials underway to test the safety and efficacy of MKC- 1 in solid and hematological cancers, including two clinical development programs in Canada. We expect to invest in further clinical trials during 2008 to test the extent of MKC-1's clinical utility in multiple tumor types."

About Ovarian and Endometrial Cancers

Ovarian cancer accounts for 4% of all cancers among women in the United States, and ranks fifth as the cause of cancer deaths. The American Cancer Society estimates that there will be approximately 22,000 newly diagnosed cases of ovarian cancer in the U.S. in 2007 resulting in approximately 15,000 deaths. About half of all ovarian cancers occur in post-menopausal women. Ovarian cancer is frequently asymptomatic in the early stages. As a result, ovarian cancer is often not diagnosed until stage III or IV, where 5-year survival rates decline to 10-20%. Current drug therapy involves paclitaxel and carboplatin/cisplatin regimens. Many patients develop resistance to these drugs, so there is substantial need for innovative therapies that can overcome resistance, either as a single agent or in combination with approved chemotherapeutic agents.

Endometrial cancer, the most common cancer found in women's reproductive organs, starts in the inner lining of the uterus
'/>"/>

SOURCE EntreMed, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. EntreMed Presents Data for Phase 2 Study of MKC-1 in Metastatic Breast Cancer
2. EntreMed Raises $20 Million to Support Clinical Development Program
3. EntreMed Reports Phase 1 PK and Preclinical Efficacy Results for ENMD-1198
4. EntreMed Shows Increased Survival With MKC-1 in Preclinical Renal Cell Cancer Model
5. EntreMed Commences Phase 2 Study with MKC-1 in Pancreatic Cancer
6. EntreMed to Present at The New York Society of Security Analysts Industry Conference
7. Memory Pharmaceuticals Commences Phase 1 Clinical Program for R4996/MEM 63908
8. Sinovac Commences Vaccination on Volunteers for Phase II Clinical Trial on Pandemic Influenza H5N1 Vaccine
9. Sunesis Pharmaceuticals Commences Clinical Trials of SNS-595 and SNS-314
10. Pharmasset Commences Dosing in Phase 3 Registration Studies of Clevudine for HBV
11. Pharmasset Commences Dosing in 28-Day Combination Study of R7128 with Pegasys(R) plus Copegus(R) for Hepatitis C
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... 2014  Hologic, Inc. (NASDAQ: HOLX ), ... and Chief Executive Officer, will preside over the NASDAQ ... first day of Breast Cancer Awareness Month. In his ... on the important benefits of Hologic,s 3D Mammography technology, ... clinically superior to traditional mammography. This is ...
(Date:9/30/2014)... , Sept. 30, 2014 Arbor ... Summary Global Markets Direct,s, ,Arbor Pharmaceuticals, ... an overview of the Arbor Pharmaceuticals, LLC.,s pharmaceutical ... comprehensive information on the current therapeutic developmental pipeline ... at various stages, therapeutics assessment by drug target, ...
(Date:9/30/2014)... DALLAS , September 30, 2014 /PRNewswire/ ... market research report the "Glycobiology/Glycomics Market by Product ... Spectrometry, MALDI-TOF), Kits, and Reagents], Application (Immunology, ... Forecast to 2019", published by MarketsandMarkets, provides ... restraints, challenges, opportunities, current market trends, and ...
Breaking Medicine Technology:Hologic to Kick Off National Breast Cancer Awareness Month at the October 1 NASDAQ Stock Market Opening Bell Ceremony 2Hologic to Kick Off National Breast Cancer Awareness Month at the October 1 NASDAQ Stock Market Opening Bell Ceremony 3Arbor Pharmaceuticals, LLC. - Product Pipeline Review - 2014 2Arbor Pharmaceuticals, LLC. - Product Pipeline Review - 2014 3Glycobiology / Glycomics Market Worth $928.11 Million by 2019 2Glycobiology / Glycomics Market Worth $928.11 Million by 2019 3Glycobiology / Glycomics Market Worth $928.11 Million by 2019 4
(Date:10/1/2014)... MI (PRWEB) October 01, 2014 To help ... wellness center , Cutler Integrative Medicine, is detailing several tips ... , According to Dr. Cutler, women should start ... quality time for yourself that will help ‘center’ yourself for ... of stress,” he says. , Other health and fitness ...
(Date:9/30/2014)... needs to be proactive about potential disease outbreaks like ... , In an Editorial in the October issue of ... , Allen Cheng from Monash University and Heath Kelly ... public health crises. , "Australia would do well to ... proactive in co-ordinating a consistent and outward looking response," ...
(Date:9/30/2014)... (HealthDay News) -- Children conceived either less than one year ... sibling could be at increased risk for autism, a new ... an outside expert agree that the research can,t prove that ... importantly, it is important that parents understand that the odds ... close together or far apart," said outside expert Dr. Andrew ...
(Date:9/30/2014)... Alan Mozes Health Day ... -- Colon cancer patients who are overweight or obese ... for developing a second weight-related cancer, new research suggests. ... of colon cancer recurrence, only the potential for developing ... that colorectal cancer survivors who reported being overweight or ...
(Date:9/30/2014)... Keystone Symposia will convene the first conference of its ... Health Series on "The Modes of Action of ... following the conclusion of the Grand Challenges Meeting for ... the Keystone Symposia Global Health Series, supported by the ... travel awards for 36 investigators from developing countries to ...
Breaking Medicine News(10 mins):Health News:In Recognition of National Women’s Health and Fitness Day, Cutler Integrative Medicine Details Tips for Living a Healthier and Happier Life 2Health News:Spacing Between Sibling Births Tied to Autism Risk in Study 2Health News:Obesity Tied to Higher Cancer Risk for Colon Cancer Survivors 2Health News:Obesity Tied to Higher Cancer Risk for Colon Cancer Survivors 3Health News:Keystone Symposia launches 2014-2015 meeting series with Global Health Vaccines Conference 2
... M&A activity in the,life sciences and healthcare sector is ... in 2008. CEOs, CFO,s and other business executives from,pharmaceutical, ... by some of the most sophisticated investors in the ... April 30-May 1, 2008,in Chicago., Deal volume in ...
... Simplifies Enrollment Process, SAN JOSE, Calif., Jan. ... the 47 million uninsured in America are,eligible for ... for Health Coverage Education (FHCE) has captured, on ... to,help people in need of health coverage., ...
... To Consumers Key Factor In Voter Opposition Compared To,Other ... than one,in five California voters (16%) support legislation, backed ... requires,proof of private health insurance when they are told ... according to a new poll., Overall, nearly two-thirds ...
... with popularity of hormone therapy, study finds , , WEDNESDAY, ... replacement therapy raise the risk of breast cancer in ... specific type of malignancy: lobular breast cancer. , The ... the January issue of Cancer Epidemiology, Biomarkers & ...
... that throughout this release there are hypnotic suggestions about why you ... you be able to pick out the suggestions? Or would they ... going on in the news, you came to the realization that ... to know unless you read on , In his fifth and ...
... with a Turn-Key Solution for Health Portal ... ... 16 HealthCare.com,( http://www.healthcare.com ), the leading healthcare provider directory and,online ... ( http://www.mediresource.com ), a leading creator and,syndicator of interactive health content ...
Cached Medicine News:Health News:Healthcare M&A Activity on the Rise 2Health News:Internet Comes to Rescue of 14 Million Uninsured in U.S.; Providing Access to Gov. Health Programs They're Not Aware of 2Health News:Internet Comes to Rescue of 14 Million Uninsured in U.S.; Providing Access to Gov. Health Programs They're Not Aware of 3Health News:New Poll: Only 16% of Californians Support Mandatory Purchase of Private Health Insurance; 71% Behind Regulation of Premium Increases 2Health News:HRT Raises Risk of Lobular Breast Cancer 2Health News:HRT Raises Risk of Lobular Breast Cancer 3Health News:Hypnotist ready to kick cigarette butt 2Health News:HealthCare.com & MediResource Partner to Distribute and License Health Content, Directory and Tools 2Health News:HealthCare.com & MediResource Partner to Distribute and License Health Content, Directory and Tools 3
Verte-Span is the latest advancement in vertebral body replacement technology. This device allows surgeons to reconstruct and stabilize certain types of anterior column defects in the spine....
... is indicated for use in the thoracolumbar spine ... or excised for the treatment of tumors, to ... neural tissues, and to restore the height of ... also indicated for treating fractures of the thoracic ...
... Ocelot stackable cage system provides anterior ... or total vertebrectomies from T1 to L5. ... Peek Carbon fiber polymer cages that are ... patient needs. The Peek Carbon fiber reinforced ...
... Ocelot stackable cage system provides anterior ... or total vertebrectomies from T1 to L5. ... Peek Carbon fiber polymer cages that are ... patient needs. The Peek Carbon fiber reinforced ...
Medicine Products: