Navigation Links
EntreMed Announces Publication Of Preclinical Results For ENMD-2076 In Triple-negative Breast Cancer
Date:11/26/2012

thways were upregulated in the more sensitive cell lines.  Within the TNBC subset itself, cell lines with a p53 mutation and increased p53 expression were more sensitive to the cytotoxic and pro-apoptotic effects of ENMD-2076 exposure than cell lines with decreased p53 expression.  This information provides the basis for a predictive biomarker strategy to explore in future clinical trials with ENMD-2076.

Dr. Jennifer R. Diamond of the University of Colorado School of Medicine, who led the study, commented, "Triple-negative breast cancer is an aggressive breast cancer subtype which carries a high risk of developing metastasis. A major barrier to the successful treatment of metastatic TNBC is the lack of effective targeted anti-cancer agents.  Through this study, we show that ENMD-2076 has activity against preclinical models of breast cancer with more robust activity against TNBC.  The study also supports further clinical investigation of ENMD-2076 in patients with metastatic TNBC with an emphasis on the continued development of p53-based predictive biomarkers."

Ken Ren, Ph.D., EntreMed's Chief Executive Officer further commented, "One of the major challenges for the development of a target therapy for cancer is the identification of a responsive subtype with a predictive biomarker. In our previous Phase 1 study, we observed a patient with TNBC who had failed multiple chemotherapy regimens then had clinically significant stabilization of disease for 41 weeks after ENMD-2076 treatment.  The benchmark of median duration after first line therapy in such patients with metastasis is just 12 weeks. This pre-clinical study illustrated scientific insight into the selective sensitivity of TNBC to ENMD-2076 with direct correlation to p53 mutation and over expression. It provides strong support for the rational of our ongoing Phase 2 TNBC trial. Upon further confirmation clinically, it may also provide guidance on future trials for patient
'/>"/>

SOURCE EntreMed, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Dana-Farber Cancer Institutes Ursula A. Matulonis, MD Article on EntreMeds ENMD-2076 Published in the European Journal of Cancer
2. EntreMed Reports Second Quarter 2012 Financial Results
3. EntreMed Announces Initiation Of Phase 2 Trial In Triple-negative Breast Cancer
4. EntreMed Reports First Quarter 2012 Financial Results
5. Trovagene Announces Closing of Private Placement of $3.76 Million from the Sale of Restricted Common Stock and Warrants
6. ResMed Inc. Announces Exchange Rate For Upcoming Dividend Payment
7. AspenBio Pharma Announces Closing of Public Offering of 1,946,000 Shares of Common Stock
8. Vasomedical Announces Financial Results for the Third Quarter of 2012
9. Proteonomix, Inc. Announces Screening of Patients with End Stage Liver Disease in its Clinical Study of UMK-121
10. Ohr Pharmaceutical Announces Additions to Ophthalmic Scientific Advisory Board
11. NeuroDerm Announces Enrollment in a Phase 1 Study of ND0612, a Continuous Levodopa/Carbidopa Drug for the Treatment of Parkinsons Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/18/2014)... 18, 2014  In a policy paper ... the nation,s largest lesbian, gay, bisexual and transgender ... of Truvada for Pre-Exposure Prophylaxis (PrEP). PrEP is ... prevent the spread of a disease or infection ... name anti-HIV drug combination currently approved for PrEP, ...
(Date:10/17/2014)... 2014  Amgen (NASDAQ: AMGN ) today ... M.D., president of Gladstone Institutes and Gladstone,s Robert W. ... "We are pleased to welcome Dr. Sandy Williams ... Bradway , chairman and chief executive officer of Amgen. ... and his direct experience in our industry will both ...
(Date:10/17/2014)... , October 17, 2014 ... Imaging Market by Technique (Optical Coherence Tomography, ... software) & by Application (Ophthalmology, Neurology, Oncology, Cardiology) - ... report studies the Optical Imaging market over ... was valued at $917.1 million in 2014 ...
Breaking Medicine Technology:HRC Endorses PrEP, Calls for Bold Action to Expand Access to Anti-HIV Drug 2HRC Endorses PrEP, Calls for Bold Action to Expand Access to Anti-HIV Drug 3Amgen Announces Appointment Of R. Sanders Williams To Board Of Directors 2Amgen Announces Appointment Of R. Sanders Williams To Board Of Directors 3Optical Imaging Market Worth $1,669.2 Million by 2019 2Optical Imaging Market Worth $1,669.2 Million by 2019 3Optical Imaging Market Worth $1,669.2 Million by 2019 4
... endpoint Clinical ( www.endpointclinical.com ), a leader in ... of PULSE 2.0™. endpoint PULSE is a proprietary platform ... systems for clinical trials in a fraction of the ... is the ability for project managers to create and ...
... Prime Therapeutics (Prime), a thought leader in pharmacy benefit ... earning it 2011 Transparency in Pharmaceutical Purchasing Standards(SM) (TIPPS) ... fourth consecutive year that Prime has received this certification. ... benefit managers (PBMs) that have agreed to provide pharmacy ...
Cached Medicine Technology:endpoint Launches PULSE 2.0 Allowing Clinical Research Teams to Save Additional Time and Money By Rapidly Deploying Studies With Custom Reporting 2Prime Therapeutics Receives 2011 TIPPS Certification 2
(Date:10/20/2014)... Allegheny General Hospital’s (AGH) Cardiovascular Institute is offering ... a damaged mitral valve as the heart continues to ... Abbott Vascular , is designed to treat degenerative ... which the heart’s mitral valve leaflets fail to close ... left ventricle into the left atrium. The heart must ...
(Date:10/20/2014)... October 20, 2014 ASCNYC (ascnyc.org) ... that helps New Yorkers living with HIV/AIDS and ... health, housing, recovery and self-sufficiency. Each year, ASCNYC ... local community through their tireless efforts. , ... Shapses , has been selected as this year’s ...
(Date:10/20/2014)... October 20, 2014 T.E.N., a ... firm, announced today that William H. Murray, renowned ... 2014 ISE® Luminary Leadership Award winner. Presented annually, ... of an outstanding leader and industry practitioner for ... in advancing the information security industry. , Formerly ...
(Date:10/20/2014)... Zereana Jess-Huff, a 34-year-old mother, corporate executive and ovarian ... to think outside the bra. She doesn’t try to hide ... awareness about women’s other lady parts. , "We have won ... color pink and everybody knows what you’re talking about,” Jess-Huff ... has not been won when it comes to gynecologic cancers. ...
(Date:10/20/2014)... My Clients Plus ( http://www.MyClientsPlus.com ) today ... new module enables easy administration and routing of follow-up ... , This application allows users such as Therapists to ... to-do item to a specific client, categorize tasks the ... reminders for follow-ups. It's designed to enable easy ...
Breaking Medicine News(10 mins):Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 2Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 3Health News:Savills Studley's Marc Shapses To Be Honored as 2014 "Positive Changemaker" by ASCNYC 2Health News:Savills Studley's Marc Shapses To Be Honored as 2014 "Positive Changemaker" by ASCNYC 3Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 2Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 3Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 4Health News:Ovarian Cancer Survivor Mrs. Maryland Urges Media to Think Outside the Bra 2Health News:Ovarian Cancer Survivor Mrs. Maryland Urges Media to Think Outside the Bra 3Health News:My Clients Plus Announces New Workflow Management Software 2
... Single men, unhappy husbands had higher incidence of dying in ... unhappily married men seem to run a greater risk of ... new Israeli study indicates. , The study, which tracked more ... 1997, found that 8.4 percent of the single men died ...
... in influenza patients and other aggressive measures helped reduce ... Those are the findings of a new study, now ... 15, 2010 issue of Clinical Infectious Diseases . ... patients visiting the emergency department at the Santiago hospital ...
... Chairman and ... donates $1 million to Autism Speaks, America,s largest autism science and advocacy organization. ... New York, NY (PRWEB) ... organization, today announced a $1 million donation by Sumner Redstone. Mr. Redstone’s gift will ...
... , ... ... , ... , , ...
... , ... ... ... ...
... , ... ... , , , , ... ...
Cached Medicine News:Health News:Happy Marriage Cuts Men's Risk for Stroke 2Health News:Aggressive response helped Chilean hospital improve H1N1 influenza outcomes 2Health News: Sumner Redstone Donates $1 Million to Autism Speaks to Support Autism Research and Programs 2Health News: Sumner Redstone Donates $1 Million to Autism Speaks to Support Autism Research and Programs 3Health News:Healthcare Trust of America, Inc. Executes Agreement to Acquire an Approximately 60,300 Square Foot Medical Office Building in Sugar Land, Texas 2Health News:Healthcare Trust of America, Inc. Executes Agreement to Acquire an Approximately 60,300 Square Foot Medical Office Building in Sugar Land, Texas 3Health News:Healthcare Trust of America, Inc. Executes Agreement to Acquire an Approximately 60,300 Square Foot Medical Office Building in Sugar Land, Texas 4Health News:Surgeon General with Microsoft HealthVault Expands Consumer Benefits for the My Family Health Portrait Offering 2Health News:Surgeon General with Microsoft HealthVault Expands Consumer Benefits for the My Family Health Portrait Offering 3Health News:Surgeon General with Microsoft HealthVault Expands Consumer Benefits for the My Family Health Portrait Offering 4Health News:Surgeon General with Microsoft HealthVault Expands Consumer Benefits for the My Family Health Portrait Offering 5Health News:Surgeon General with Microsoft HealthVault Expands Consumer Benefits for the My Family Health Portrait Offering 6Health News:Princess Haya Calls for Action to Protect Health in the Developing World 2Health News:Princess Haya Calls for Action to Protect Health in the Developing World 3Health News:Princess Haya Calls for Action to Protect Health in the Developing World 4
... Our variable volume Finnpipette ... in a high performance pipette. ... colour-coded volume range, ensures quality, ... identification of the volume range ...
... is a fully adjustable, air-displacement pipette with ... the latest member of the Pipetman family, ... accuracy, and precision. We also added a ... our customers. Eight models cover the full ...
... is precision, ergonomics, and value!, ... with soft non-slip, contoured handle , ... light plunger spring action , Completely ... without the need for recalibration , ...
... from 2ul to 5000ul. Fills and empties ... inadvertent volume change. Novel hand grip shape ... autoclavable at 121C(250F). To prevent corrosion the ... one-handed operation. Auto or Normal trigger mode. ...
Medicine Products: