Navigation Links
EntreMed Announces Publication Of Preclinical Results For ENMD-2076 In Triple-negative Breast Cancer
Date:11/26/2012

thways were upregulated in the more sensitive cell lines.  Within the TNBC subset itself, cell lines with a p53 mutation and increased p53 expression were more sensitive to the cytotoxic and pro-apoptotic effects of ENMD-2076 exposure than cell lines with decreased p53 expression.  This information provides the basis for a predictive biomarker strategy to explore in future clinical trials with ENMD-2076.

Dr. Jennifer R. Diamond of the University of Colorado School of Medicine, who led the study, commented, "Triple-negative breast cancer is an aggressive breast cancer subtype which carries a high risk of developing metastasis. A major barrier to the successful treatment of metastatic TNBC is the lack of effective targeted anti-cancer agents.  Through this study, we show that ENMD-2076 has activity against preclinical models of breast cancer with more robust activity against TNBC.  The study also supports further clinical investigation of ENMD-2076 in patients with metastatic TNBC with an emphasis on the continued development of p53-based predictive biomarkers."

Ken Ren, Ph.D., EntreMed's Chief Executive Officer further commented, "One of the major challenges for the development of a target therapy for cancer is the identification of a responsive subtype with a predictive biomarker. In our previous Phase 1 study, we observed a patient with TNBC who had failed multiple chemotherapy regimens then had clinically significant stabilization of disease for 41 weeks after ENMD-2076 treatment.  The benchmark of median duration after first line therapy in such patients with metastasis is just 12 weeks. This pre-clinical study illustrated scientific insight into the selective sensitivity of TNBC to ENMD-2076 with direct correlation to p53 mutation and over expression. It provides strong support for the rational of our ongoing Phase 2 TNBC trial. Upon further confirmation clinically, it may also provide guidance on future trials for patient
'/>"/>

SOURCE EntreMed, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Dana-Farber Cancer Institutes Ursula A. Matulonis, MD Article on EntreMeds ENMD-2076 Published in the European Journal of Cancer
2. EntreMed Reports Second Quarter 2012 Financial Results
3. EntreMed Announces Initiation Of Phase 2 Trial In Triple-negative Breast Cancer
4. EntreMed Reports First Quarter 2012 Financial Results
5. Trovagene Announces Closing of Private Placement of $3.76 Million from the Sale of Restricted Common Stock and Warrants
6. ResMed Inc. Announces Exchange Rate For Upcoming Dividend Payment
7. AspenBio Pharma Announces Closing of Public Offering of 1,946,000 Shares of Common Stock
8. Vasomedical Announces Financial Results for the Third Quarter of 2012
9. Proteonomix, Inc. Announces Screening of Patients with End Stage Liver Disease in its Clinical Study of UMK-121
10. Ohr Pharmaceutical Announces Additions to Ophthalmic Scientific Advisory Board
11. NeuroDerm Announces Enrollment in a Phase 1 Study of ND0612, a Continuous Levodopa/Carbidopa Drug for the Treatment of Parkinsons Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... , Jan. 15, 2014  Manufacturers, suppliers and distributors ... able to protect their most important business assets, ... ) Because of the highly-competitive ... remains one of the most litigious industry sectors ...
(Date:1/15/2014)... 2014 MultiCell Technologies, Inc. (OTC Bulletin Board: ... application concerning composition of matter, biological targets, mechanism of ... death.  This patent application describes a ... molecules (VSRNAs) which interfere with the basic homeostatic cellular ...
(Date:1/15/2014)... 2014  According to Millennium Research Group (MRG), the ... the United States and European ... expand moderately through 2022, with embolization particles representing ... interest in drug-eluting beads (DEBs) and radioembolization spheres ...
Breaking Medicine Technology:Intellectual Property Insurance for Medical-related Products and Services 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 3US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 2US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 3
(Date:4/14/2014)... been made in chemotherapy over the past decade, but ... continues to be a major challenge. , Nanotechnology ... the use of nanocarriers, or capsules, that can transport ... body. , The catch? These carriers are tiny, and ...
(Date:4/14/2014)... the 20th century, is currently losing a lot of ... at the University of South Carolina have just reported ... against so-called "superbugs." , Bacteria have been chipping away ... since their first wide-scale use as antibiotics in the ...
(Date:4/14/2014)... web information on colorectal cancer is too difficult for ... appropriate risks to and concerns of patients, a study ... a review of a dozen popular websites, most of ... were written beyond the recommended sixth-grade reading level, while ...
(Date:4/14/2014)... Inc., announced today a publication demonstrating that the company,s ... cells exposed to plasma samples of patients with a ... "TNT003, an inhibitor of the serine protease C1s, prevents ... was published on-line in the journal Blood ...
(Date:4/14/2014)... Child Development Institute have released their new study of ... success in kindergarten. According to FPG,s report, students enrolled ... of learning. , "Children are progressing at an ... than expected for normal developmental growth," said senior scientist ...
Breaking Medicine News(10 mins):Health News:Nano shake-up 2Health News:Penicillin redux: Rearming proven warriors for the 21st century 2Health News:Penicillin redux: Rearming proven warriors for the 21st century 3Health News:Website information on colon cancer too complex, fails to address key concerns 2Health News:Website information on colon cancer too complex, fails to address key concerns 3Health News:Ex vivo efficacy of C1s antibody as Complement inhibitor in cold agglutinin disease 2Health News:Study gives high marks to NC Pre-K program 2
... Skin cancer is the most common form of cancer and nearly ... to the skin. What is all the more alarming is that ... of sunburn & skin cancer admit they still get sunburnt despite ... ,Chronic exposure to sunlight is the cause of nearly ...
... obesity and people who are overweight, may not be ... systematically reviewed the current evidence for the supplement had ... Cochrane Library.// ,The review assessed results ... or obese adults. Those who received chitosan had an ...
... the people in South India wake up to the lovely ... celebrate for these coffee lovers now, with firm evidence from ... a morning jolt and has been found to contain substances ... Antioxidants in general have been linked to a number of ...
... common cancer diagnosed in men and the risk of ... the best form of therapy for prostate cancer remains ... options are available to patients: traditional open surgery, laparoscopic ... surgery. ,Prostate cancer patients biggest concerns following ...
... women who try to lose weight apparently have to choose ... weight loss , the supermodel Rachel Hunter has criticized "Desperate ... loss. , ,Hunter said that Hatcher's face looked older ... was once married to rocker Rod Stewart, went on to ...
... 28 : Researchers report that mother to be who ... on the growth of their unborn babies., ,Researchers ... adverse pregnancy outcomes // - primary caesarean delivery, pre-term ... group., ,Terry J. Rosenberg of Medical Health and ...
Cached Medicine News:Health News:Benefits Of Robotic Prostate Surgery- But At What Cost? 2Health News:Hollywood Actress Hunter criticises Hatcher for weight loss. 2Health News:Obesity, diabetes in pregnant women affects babies 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: