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EntreMed Announces Initiation Of Phase 2 Trial In Advanced/Metastatic Soft Tissue Sarcoma
Date:1/23/2013

ROCKVILLE, Md., Jan. 23, 2013 /PRNewswire/ -- EntreMed, Inc. (Nasdaq: ENMD), a clinical-stage pharmaceutical company, announced today the initiation of a single-center Phase 2 study entitled "A Phase 2 Study of Oral ENMD-2076 Administered to Patients with Advanced/Metastatic Soft Tissue Sarcoma" at Princess Margaret Hospital where the study is led by Malcolm Moore , MD and Albiruni R.A. Razak, MD.  The study is sponsored by Princess Margaret Cancer Centre. More information about the clinical trial can be found at www.clinicaltrials.gov.

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Albiruni R.A. Razak, MD, commented on the study, "Soft tissue sarcomas (STS) are diverse mesenchymal tumors that commonly affect patients in the prime of life.  The prognosis for patients with advanced/metastatic sarcoma remains poor and there are limited options for their treatment.  The median disease progression-free survival (PFS) for those patients is less than two months without treatment or less than five months with treatments currently available. This is certainly an area of unmet medical need.  The primary objective of this Phase 2 study is to evaluate the safety and efficacy of ENMD-2076 in advanced/metastatic STS patients with the 6 month PFS rate as the end point of the study.  We will also perform biomarker correlative studies that may define patients with a superior/inferior progression free survival. A number of pre-clinical and clinical investigations have provided encouraging results for the use of ENMD-2076 in the treatment of various types of cancer, including sarcoma.  We believe the co-inhibition of Aurora kinase A and angiogenesis would render ENMD-2076 an
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SOURCE EntreMed, Inc.
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