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EntreMed Announces Changes to Board of Directors and CEO Appointment
Date:4/5/2013

of every committee of the Board.  We sincerely wish Mark all the best in the future and thank him very much for his service to our Company."

EntreMed further announced that Ken K. Ren , Ph.D. has been appointed Chief Executive Officer, after having completed his one-year term as interim CEO.  Dr. He stated, "Over the past year, Ken has been instrumental in developing and executing the Company's strategy and has demonstrated executive leadership and navigated development of our ENMD-2076 program to create value for our shareholders.  We are thrilled that Ken will continue to lead the Company into a promising future."

About EntreMed

EntreMed, Inc. is a clinical-stage pharmaceutical company employing a drug development strategy primarily in the United States and China to develop targeted therapeutics for the global market.  Its lead compound, ENMD-2076, a selective angiogenic kinase inhibitor, has completed several Phase 1 studies in solid tumors, multiple myeloma, and leukemia, and is currently completing a multi-center Phase 2 study in ovarian cancer.  EntreMed, Inc. recently announced the initiation of a Phase 2 study of ENMD-2076 in triple-negative breast cancer and the initiation of a Phase 2 study of ENMD-2076 in advanced/metastatic soft tissue sarcoma.  Additional information about EntreMed is available on the Company's web site at www.entremed.com and in various filings with the Securities and Exchange Commission (the SEC).

About ENMD-2076

ENMD-2076 is an orally-active, Aurora A/angiogenic kinase inhibitor with a unique kinase selectivity profile and multiple mechanisms of action.  ENMD-2076 has been shown to inhibit a distinct profile of angiogenic tyrosine kinase targets in addition to the Aurora A kinase.  Aurora kinases are key regulators of mitosis (cell division), and are often over-expres
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