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Enobia Initiates Infantile Enzyme Replacement Trial for Rare Bone Disease
Date:12/1/2008

Baby Girl with Hypophosphatasia Treated With ENB-0040 at Children's Hospital, Health Sciences Centre in Winnipeg

MONTREAL, Dec. 1 /PRNewswire/ -- Enobia Pharma, an emerging Canadian biotech company focused on developing novel therapeutics for serious bone disorders, today announced that the first infant patient in its clinical program for hypophosphatasia was dosed. Enobia is investigating Enzyme Replacement Therapy (ERT) with ENB-0040 for the treatment of this rare and often crippling genetic bone disorder for which there is no approved treatment.

"Our enzyme replacement therapy program for hypophosphatasia has progressed well," said Robert Heft, CEO of Enobia. "Based upon the excellent preclinical data we are hopeful that hypophosphatasia patients will benefit from treatment with ENB-0040. We're grateful for everyone involved in expediting the treatment of this patient."

Under two separate protocols, ENB-0040 will be evaluated in both adults and infants afflicted with hypophosphatasia at sites in Canada and the United States. In August, physicians at the University of Manitoba dosed the first adult patient as part of that cohort to evaluate the safety, tolerability and pharmacokinetics of ENB-0040.

Enobia Pharma is pleased to reproduce below today's announcement made by Children's Hospital, Health Sciences Centre Winnipeg regarding the dosing of the first infant patient in the early ENB-0040 studies.

    CHILD RECEIVING POTENTIALLY LIFE-SAVING TREATMENT AT HSC AS PART OF INTERNATIONAL DRUG TRIAL

    Infant Girl From Belfast Flown To Winnipeg

WINNIPEG - A 9-month-old baby girl from Belfast is receiving potentially life-saving experimental treatment at Children's Hospital, Health Sciences Centre Winnipeg as part of an international drug trial.

The child has a bone disorde
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SOURCE Enobia Pharma Inc.
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