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Endpoints - Clinical Trials in Respiratory Diseases - Pulmonary Function Tests, Biomarkers and Quality of Life Questionnaires All Play Prominent Roles
Date:8/27/2012

rminated Trial Analysis 495 Endpoints - Clinical Trials in Chronic Obstructive Pulmonary Disorder - Marketed and Pipeline Products Assessment 765.1 Introduction 765.2 Primary Endpoints Used in COPD Clinical Trials 805.2.1 Pulmonary Function Tests 805.2.2 Baseline Dyspnea Index and Borg-Dyspnea Score 805.2.3 Rate of Exacerbations 805.2.4 Induced Sputum Analysis 805.2.5 Biomarkers of COPD 805.3 Secondary Endpoints Used in COPD Clinical Trials 805.3.1 Exercise Endurance Time 805.3.2 Serum Hematology 805.3.3 Six Minute Walk Distance 805.3.4 Time to First Exacerbation 815.4 COPD Therapeutics – Major Marketed Drugs 815.4.1 Spiriva HandiHaler (Tiotropium Bromide Inhalation Powder) 815.4.2 Brovana (Arformoterol) 825.4.3 Foradil Aerolizer (Formoterol Fumarate Inhalation Powder) 835.4.4 Symbicort (Budesonide/Formoterol Fumarate Dihydrate) 845.4.5 Advair Diskus (Fluticasone Propionate and Salmeterol Inhalation Powder) 855.4.6 Daxas (roflumilast) 875.5 COPD Therapeutics – Promising Drugs Under Clinical Development 885.5.1 Aclidinium Bromide 885.5.2 NVA237 (Glycopyrronium Bromide) 895.5.3 Dulera 895.6 Phase III Clinical Trial Analysis 905.6.1 Completed Trial Analysis 905.6.2 Active Trials Analysis 945.6.3 Terminated Trial Analysis 985.7 Phase II Clinical Trial Analysis 1005.7.1 Completed Trial Analysis 1005.7.2 Active Trial Analysis 1045.7.3 Terminated Trial Analysis 1076 Endpoints - Clinical Trials in Cystic Fibrosis - Marketed and Pipeline Products Assessment 1256.1 Introduction 1256.2 Primary Endpoints Used in Cystic Fibrosis Clinical Trials 1296.2.1 Coefficient of Fat Absorption 1296.2.2 Lung Microbiology 1296.2.3 Biomarkers 1296.3 Secondary Endpoints Used in Cystic Fibrosis Clinical Trials 1296.3.1 Nasal Potential Difference 1296.3.2 Sweat Chloride Concentration 1296.4 Cystic Fibrosis Therapeutics – Major Marketed Drugs 1296.4.1 Tobi (Tobramycin Inhalation Solution) 1296.4.2 Pulmozyme (Dornase Alfa) 1306.4.3 Cayston (aztreonam for Inhalation Solution) 1316
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