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Enbrel Will Remain Decision Resources' Clinical Gold Standard Through 2018 for the Treatment of Rheumatoid Arthritis
Date:1/12/2010

WALTHAM, Mass., Jan. 12 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that Amgen/Pfizer/Takeda's Enbrel will retain Decision Resources' proprietary clinical gold standard status for the treatment of rheumatoid arthritis through 2018. Although Centocor Ortho Biotech/Merck/Mitsubishi Tanabe/Janssen's Simponi offers delivery advantages over Enbrel in formulation (potentially offered in both subcutaneous and intravenous formulations) and dosing frequency (once monthly compared with once or twice weekly for Enbrel), neither Simponi nor any other rheumatoid arthritis biologic have the same effect as Enbrel in inhibiting/slowing structural damage progression.

The new report entitled Rheumatoid Arthritis: Opportunity Awaits Therapies that Meet Physicians' Efficacy Expectations in TNF-α Inhibitor-Refractory Patients also finds that rheumatologists are unwilling to compromise on efficacy or convenient delivery for a disease-modifying drug with a novel mechanism of action for patients who are refractory to tumor necrosis factor alpha (TNF-alpha) inhibitors, even if such an agent entered the market at a lower price point than leading biologics. Surveyed U.S. rheumatologists stated that such a drug (that doesn't compromise on efficacy) could be prescribed to 63 percent of eligible U.S. patients. Surveyed European rheumatologists indicated that such an agent could be prescribed to 75 percent of eligible European patients.

"Because we believe the TNF-alpha inhibitors will remain the most prescribed treatments for patients who have failed or lost response to conventional disease-modifying antirheumatic drugs, we profiled the opportunity for an agent in the TNF-alpha inhibitor-refractory population in our study. High price, intravenous deliver
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SOURCE Decision Resources
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