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EnVivo Pharmaceuticals Research Shows EVP-6124 Acts as Acetylcholine Co-Agonist
Date:11/5/2010

memory function in these animals.

"Low doses of EVP-6124 could enhance current cholinergic treatments and when combined with available agents could provide a pro-cognitive effect for as long as acetylcholine is present in the brain," said Dr. Jeff Cummings, director of the Cleveland Clinic Lou Ruvo Center for Brain Health (Las Vegas, Nevada and Cleveland, Ohio).  "EnVivo's experimental results suggest that pro-cognitive drugs could be taken in earlier stages of Alzheimer's disease and that EVP-6124 could continue to boost the pro-cognitive effect of cholinesterase inhibitors throughout the disease course.  The effectiveness of reduced doses of cholinesterase inhibitors when given with EVP-6124 in experimental models suggests that EVP-6124 might allow use of lower doses with fewer side effects in humans."

The results of EnVivo's ongoing Phase IIb trial, expected in the second half of 2011, will hopefully further corroborate EnVivo's most recent findings.

About EnVivo Pharmaceuticals

EnVivo Pharmaceuticals, located in Watertown, Mass., is a biopharmaceutical company dedicated to discovering and developing small molecule therapeutics for disorders of the central nervous system, with a current focus on Alzheimer's disease, cognitive disorders and schizophrenia.  The company's lead product is an alpha-7 nicotinic acetylcholine receptor agonist and is currently in Phase IIb clinical trials for cognition disorders in Alzheimer's disease and schizophrenia.  The company's other programs include an epigenetics program based on Histone Deacetylase inhibition (HDACi) with EVP-0334 as the lead molecule which is in preparation for Phase II studies, and several preclinical programs such as a Gamma Secretase Modulator (for Alzheimer's disease) and a PDE10 inhibitor program (for schizophrenia), expected to enter the clinic in 2011.  For more information about'/>"/>

SOURCE EnVivo Pharmaceuticals
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