Navigation Links
EnVivo Pharmaceuticals Research Shows EVP-6124 Acts as Acetylcholine Co-Agonist
Date:11/5/2010

WATERTOWN, Mass., Nov. 5, 2010 /PRNewswire/ -- EnVivo Pharmaceuticals today announced it has discovered that EVP-6124, its alpha-7 nicotinic acetylcholine receptor agonist, possesses a novel mechanism not previously seen in the scientific community: it acts as a co-agonist with Acetylcholine (ACh) to enhance cognition.

By acting as a co-agonist and sensitizing the alpha-7 receptor, EVP-6124 makes it possible for smaller amounts of naturally occurring ACh, typically found in individuals with memory disorders such as Alzheimer's, to be required to activate the receptor.  In this scenario, EnVivo's research demonstrated that memory deficits can be minimized or entirely reversed by controlling the neuronal channel with EVP-6124 alone or in combination with other Alzheimer's drugs.

"This is groundbreaking research in terms of understanding how the alpha-7 receptor operates in conjunction with EVP-6124," said Kees Been, president and CEO of EnVivo.  "The potential, as evidenced in our studies, is significant for how we look at and approach the treatment of Alzheimer's disease."

EnVivo simulated physiologically relevant brain conditions in vitro and alpha-7 receptor action was measured in response to ACh in the presence of low EVP-6124 concentrations.  At drug concentrations resulting in pro-cognitive effects in in vivo studies, EVP-6124 appeared to significantly increase the alpha-7 receptor response to ACh.  This suggests that at low concentrations, EVP-6124 acts as a co-agonist and sensitizes the alpha-7 receptor to its natural response to ACh, but does not desensitize the receptor.  This co-agonist mechanism of action was supported by testing the combined effect of sub-threshold doses of both EVP-6124 and donepezil (Aricept) on the memory deficit in a rat model.  While each drug alone at these very low doses had no effect on reversing the deficit, dosing the two agents together completely restored the
'/>"/>

SOURCE EnVivo Pharmaceuticals
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. EnVivo Pharmaceuticals Announces Significant Results from GSM Transgenic Mouse Model for Alzheimers Disease
2. EnVivo Pharmaceuticals Announces Initiation of Clinical Safety and Biomarker Study of Alpha-7 Nicotinic Agonist, EVP-6124, in Patients with Schizophrenia
3. EnVivo Pharmaceuticals Announces Progress on Major Drug Programs Focusing on Alzheimers, Schizophrenia and Huntingtons Diseases
4. Cadence Pharmaceuticals Reports Third Quarter 2010 Financial Results
5. Neuraltus Pharmaceuticals Awarded $733,437 Under the Qualifying Therapeutic Discovery Projects Grant Program (QTDP)
6. Inspiration Biopharmaceuticals Awarded Two Grants Under the Qualifying Therapeutic Discovery Projects Grant Program (QTDP)
7. Savient Pharmaceuticals Announces Expected Availability of KRYSTEXXAâ„¢ for Prescription and Reports Third Quarter 2010 Financial Results
8. Penwest Pharmaceuticals Shareholders Approve Merger With Subsidiary of Endo Pharmaceuticals
9. Arena Pharmaceuticals Provides Update on GPR119 Portfolio for Type 2 Diabetes
10. Keryx Biopharmaceuticals, Inc. Announces Third Quarter 2010 Financial Results
11. Onyx Pharmaceuticals to Present at the Credit Suisse 2010 Healthcare Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... NEW YORK , January 15, 2014 ... BreedIT Ltd., the exclusive worldwide distributor of highly sophisticated ... that on January 7, 2014, the Company,s board of ... Ben-Zion Weiner as its new member of the ...
(Date:1/15/2014)... PALM BEACH GARDENS, Fla. , Jan. 15, 2014  In an ... C. difficile and TB in ambulances and other transport vehicles, an ... being used by rescue personnel for the first time. ... coming in contact with these deadly pathogens, West Palm ...
(Date:1/15/2014)... 2014 MultiCell Technologies, Inc. (OTC Bulletin Board: ... application concerning composition of matter, biological targets, mechanism of ... death.  This patent application describes a ... molecules (VSRNAs) which interfere with the basic homeostatic cellular ...
Breaking Medicine Technology:BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 2BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 3Superbugs No Longer Ride In Rescue Vehicles 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 3
... industry is expecting a busy summer this year, and ... Day weekend, more hotels and resorts are raising their ... according George Clarke, CEO of UMF Corporation, a developer ... hotels and resorts adopting environmental hygiene practices developed for ...
... SAN FRANCISCO, May 22, 2012  Boehringer Ingelheim announced ... the investigational compound tiotropium delivered once-daily via the ... moderate persistent asthma. The data were presented at ... Society (ATS 2012). Boehringer Ingelheim announced that a ...
Cached Medicine Technology:With Busy Summer Forecast Ahead, More Hotels Are Raising Hygiene Standards, Says UMF Corporation 2Boehringer Ingelheim Presents First Data for Tiotropium in Adolescents with Moderate Persistent Asthma 2Boehringer Ingelheim Presents First Data for Tiotropium in Adolescents with Moderate Persistent Asthma 3Boehringer Ingelheim Presents First Data for Tiotropium in Adolescents with Moderate Persistent Asthma 4
(Date:4/24/2014)... the corresponding terminology, and the relevance of palliation ... publications on randomized controlled trials (RCTs). This is ... Institute for Quality and Efficiency in Health Care ... report. , Together with external experts, IQWiG analysed ... lung cancer, malignant melanoma, and pancreatic cancer. For ...
(Date:4/24/2014)... 4/24/14) Dartmouth has been awarded one of 30 ... as a Lead Academic Participating Site in its new ... recipients are a select groups of investigators charged with ... cooperative groups., The NCTN grant system reflects recommendations from ... streamlines operations to achieve four goals:, Faster ...
(Date:4/23/2014)... A pilot study by Massachusetts General Hospital (MGH) investigators ... unusual treatment for a serious medical problem use ... diarrhea caused by the Clostridium difficile ( ... published online in the journal Clinical Infectious Diseases ... fecal material from donors unrelated to patients was as ...
(Date:4/23/2014)... O,Shea, M.D., scientific director at the National Institute of ... named the 2014 recipient of the Ross Prize in ... journal Molecular Medicine . The award will be ... of Sciences in Manhattan, followed by scientific presentations by ... of the National Institutes of Health. , The award, ...
(Date:4/23/2014)... an important enzyme pathway that helps prevent new cells ... condition that has been directly linked to cancer and ... found that near the end of cell division, the ... breaks in DNA are fully repaired before the parent ... This process helps safeguard against some of the most ...
Breaking Medicine News(10 mins):Health News:Palliation is rarely a topic in studies on advanced cancer 2Health News:Palliation is rarely a topic in studies on advanced cancer 3Health News:Dartmouth awarded lead role in NCI clinical trials network 2Health News:Dartmouth awarded lead role in NCI clinical trials network 3Health News:Use of frozen material for fecal transplant successfully treats C. difficile infection 2Health News:Use of frozen material for fecal transplant successfully treats C. difficile infection 3Health News:NIH scientist to receive Ross Prize in Molecular Medicine 2Health News:Study identifies enzymes that help fix cancer-causing DNA defects 2
... of terminally ill cancer patients, researchers at Dana-Farber Cancer ... cope with their illness are more likely to receive ... that often entails a lower quality of life in ... more religious patients often prefer aggressive end-of-life (EOL) treatment. ...
... economic crisis contributing to greater workplace stress, providing effective ... than ever. , Unfortunately, the approach most companies take ... unlikely to produce the best outcomes for either their ... Florida State University College of Medicine researcher. , Kathryn ...
... March 17 A federal jury in Miami today ... with a $5.3 million Medicare fraud scheme, Acting Assistant ... and U.S. Attorney R. Alexander Acosta of the Southern ... court in Miami, a jury found David Rothman, M.D., ...
... following event was announced today by the American Red ... Los Angeles Red Cross is hosting a lunch reception ... (EOC), which is ready to be activated during major ... the size of Hurricane Katrina. A video with earthquake ...
... , ... Denver -- As part of its ongoing commitment to encourage ... (AWWA), the authoritative resource on safe water, today announced it will partner ... in Las Vegas., , , , ,Debuted last year by the Southern ...
... but figures decline, report finds , , TUESDAY, March 17 ... abuse in the United States have risen dramatically over ... abuse admissions in 1997 to 5 percent in 2007, ... Alcohol was still the leading cause (40 percent) of ...
Cached Medicine News:Health News:Link between religious coping and aggressive treatment in terminally ill cancer patients 2Health News:Link between religious coping and aggressive treatment in terminally ill cancer patients 3Health News:Researcher wins $2.6 million grant for depression care study 2Health News:Researcher wins $2.6 million grant for depression care study 3Health News:Jury Convicts Two Doctors and Two Medical Assistants in $5.3 Million Medicare Fraud Scam 2Health News:Jury Convicts Two Doctors and Two Medical Assistants in $5.3 Million Medicare Fraud Scam 3Health News:Jury Convicts Two Doctors and Two Medical Assistants in $5.3 Million Medicare Fraud Scam 4Health News:State-of-the-Art Preparedness: L.A. Red Cross Opens Advanced Emergency Operations Center 2Health News:AWWA partners with WaterSmart Innovations conference 2Health News:Admissions for Prescription Painkiller Abuse on Rise 2
Plastic Block Filing Cabinet is a durable, six-drawer unit that holds up to 1500 slides....
Shandon Carousel Cassette MicroWriter™ is a carousel-type cassette marking system....
Micro-slide cabinet space saving design, stores as many as 54,000 slides in only two square feet of floor space. Cabinets and base come in 3 colors....
Fisherbrand* Micro Slide Cabinet is made of heavy gauge, reinforced steel....
Medicine Products: