Navigation Links
EnVivo Pharmaceuticals Announces Progress on Major Drug Programs Focusing on Alzheimer's, Schizophrenia and Huntington's Diseases
Date:10/17/2007

WATERTOWN, Mass., Oct. 17 /PRNewswire/ -- EnVivo Pharmaceuticals, Inc., a privately held biopharmaceutical company developing drugs for neurodegenerative diseases, today announced progress on several key programs for addressing Alzheimer's, Schizophrenia and Huntington's diseases.

EnVivo Pharmaceuticals is developing EVP6124, a selective, orally active Alpha 7 Nicotinic Acetylcholine Receptor Agonist for the treatment of cognitive deficits associated with Alzheimer's disease and Schizophrenia. The Company today announced the commencement of a second Phase I multiple ascending dose study in healthy young volunteers at very low doses to further establish safety factors and evidence of cognitive enhancement. In previously completed Phase I studies a positive signal consistent with the mechanism of action and suggestive of a pro-cognitive effect was shown.

In a related matter, the Company announced approval of an Investigational New Drug (IND) Application from the U.S. Food and Drug Administration for a Phase IIA Schizophrenia study that is scheduled to begin in early 2008. It is anticipated that Alpha 7 agonist compounds will improve cognitive function in Schizophrenia and Alzheimer's patients.

Additionally, the Company reported that a lead compound has emerged from its Histone Deacetylase Inhibitor (HDACi) program. The goal of the program is to further evaluate this lead compound with a view to potentially commencing clinical trials in 2008, in mutual agreement with partner MethylGene. The company believes that this lead compound represents one of the first highly potent, orally bio-available and brain-permeable HDAC inhibitors for neuro- degenerative diseases. HDAC inhibitors hold promise for treating the cognitive deficits of several diseases including Alzheimer's disease and Parkinson's Disease as well as slowing the progression of neuro-degenerative diseases such as Huntington's disease.

Finally, the Company announced the appointment of Maria S. Gawryl, 53, as Senior Director and program executive for the Alpha 7 initiative. Dr. Gawryl has more than 20 years of pharmaceutical experience with companies such as RenaMed Biologics, Biopure Corporation, Baxter and Bioscience associates, as well as research experience at academic institutions such as Harvard and Yale University School of Medicine. She has executed and completed numerous multinational clinical trials and over 250 preclinical studies. She holds a Bachelor of Science in Chemistry and Mathematics from Antioch College, a Ph.D. in Immunology/Biomedical Sciences from the University of Connecticut and completed post-doctoral research at Rush Medical College in Chicago.

"Our Company is continuing to make steady progress across all programs of our pipeline, so we are privileged to have such an experienced clinical pharmacologist join our teams to further advance these important programs into later-stage clinical trials" stated Kees Been, EnVivo's President and Chief Executive Officer.

EnVivo Pharmaceuticals is a biopharmaceutical company dedicated to discovering and developing drugs for central nervous system (CNS) disorders including, Alzheimer's disease, Parkinson's disease and Huntington's disease. The company's lead programs include a Nicotinic Acetylcholine Receptor Agonist Program (alpha-7) for Alzheimer's disease and Schizophrenia, a Histone Deacetylase Inhibitor (HDACi) Program for Huntington's disease and several other programs such as the EVP2442 program for neuro-protection and the PDE10 inhibitor and gamma-secretase modulator programs. More information about EnVivo is available at http://www.envivopharma.com .


'/>"/>
SOURCE EnVivo Pharmaceuticals, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Related medicine technology :

1. Inspiration Biopharmaceuticals Presents Data From Hemophilia Program at International Society On Thrombosis and Haemostasis (ISTH) Annual Meeting
2. BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine
3. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
4. Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for Oral Oleoyl-estrone
5. Auxilium Pharmaceuticals to Present at the 2007 CEUT Emerging Growth Opportunities Conference
6. Sunesis Pharmaceuticals to Present at the C. E. Unterberg, Towbin Emerging Growth Conference
7. EPIX Pharmaceuticals to Present at the C.E. Unterberg, Towbin Emerging Growth Opportunities Conference
8. Pro-Pharmaceuticals Updates Progress of Clinical Trials & Davanat 505 (b)(2) Filings
9. Cosmo Pharmaceuticals Reports Positive Preliminary Phase II/III Data with Rifamycin MMX in Infectious Diarrhea
10. Portola Pharmaceuticals Announces Positive Phase II EXPERT Results and Additional Oral and Poster Presentations at the XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH)
11. Keryx Biopharmaceuticals, Inc. Announces Positive Phase I and Phase II Data on KRX-0401 in Patients with Relapsed/Refractory Multiple Myeloma and Waldenstroms Macroglobulinemia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/10/2017)... -- NDS received FDA 510(k) clearance in May 2017 for its highly ... designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... support the improvement of patient outcomes, procedural efficiency, and the lowering ... ... ...
(Date:10/4/2017)... 4, 2017  South Korean-based healthcare product Development Company ... "cprCUBE" on Kickstarter. The device will educate the user ... with better efficiency compared to the dated and pricey ... on efficacy of the compression for a more informed ... goal to raise $5,000. ...
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
Breaking Medicine Technology:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and ... plans to open a flagship location in Covington, LA at 401 N. U.S. Highway ... store next to Office Depot in the Holiday Square shopping center. Its location allows ...
(Date:10/12/2017)... ... 2017 , ... Asante, a nationally recognized health system in ... existing home health joint venture through an agreement, effective October 1, 2017, to ... home health company with Asante, delivering clinically integrated care, for the past eight ...
Breaking Medicine News(10 mins):