Emisphere Presents Dramatic Clinical Evidence Demonstrating New Approach to Vitamin B12 Suppl...(certaincommercially available formulatio...),Health

Mean Vitamin B12 peak blood levels were more than 10 times higher for the Eligen(R) B12 5mg formulation than for the 5mg commercial formulation (12847 pg/ml and 1239 pg/ml, respectively). The time to reach peak concentration (Tmax) was reduced by over 90%; the mean was 0.5 hours for the Eligen(R) B12 5mg and 6.8 hours for the commercial 5mg product. Mean AUC_(24h) values were 54618 for Eligen(R) B12 and 23131 for the commercial 5mg product. Improvement in bioavailability was approximately 240%, with absorption time at 30 minutes and a mean bioavailability of 5%. The study was conducted with a single administration of Vitamin B12; there were no adverse reactions, and Eligen(R) B12 was well-tolerated.

"These data hold real promise for improving the way we approach Vitamin B12 supplementation, including maintenance of adequate Vitamin B12 status in individuals at risk or already defined as B12 deficient," Donald W. Jacobsen, Ph.D., Staff, Cleveland Clinic and Professor of Molecular Medicine, Case Western Reserve University "In these populations we can expect the differences between the Eligen(R) B12 and the regular oral formulations to be greater as this study was performed in healthy male volunteers."

This human study follows a number of animal studies that also indicated the advantages of the Eligen(R) Technology when applied to a poorly absorbed but essential nutrient such as Vitamin B12. "Emisphere is committed to further demonstrating the value of the Eligen(R) Technology and commercializing it, especially for restoring B12 levels in those at risk, those who are identified as deficient, and for people who are genuinely concerned about this significant and essential vitamin," said Mr. Novinski. "Furthermore, this data clearly show how b
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