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Elusys Awarded $68 Million Contract to Develop Anthim for Intramuscular Pre- and Post-Exposure Prophylaxis of Anthrax Infection
Date:9/8/2011

Inhaled anthrax is often fatal, even if treated with antibiotics, if not treated soon after exposure. If all activities in the ETI-204 development program are completed to the U.S. Food and Drug Administration's (FDA) satisfaction, the federal government could purchase Anthim for the Strategic National Stockpile (SNS) under Project BioShield. Project BioShield was established in 2004 to provide much needed funding to procure important countermeasures to protect the American public in the event of a biowarfare attack.

This funding is in addition to a separate contract, totaling up to $143 million over five years, previously awarded for development of Anthim for treatment of symptomatic patients. Funding will be provided by the Biomedical Advanced Research and Development Authority (BARDA), within the Office of the Assistant Secretary for Preparedness and Response in the U.S. Department of Health and Human Services. 

Leslie Casey, PhD, Vice President of Research commented that, "In a recent animal study, a single IM dose of Anthim provided a 92% survival rate when administered 18 hours after exposure to anthrax. All surviving animals tested negative for anthrax bacteria by study day 14. The results of this study, in addition to other animal studies previously conducted by the company, continue to demonstrate the significant survival benefit of ETI-204 when given to anthrax exposed animals." This research was funded by the U.S. Department of Defense, Joint Program Executive Office for Chemical and Biological Defense - Chemical Biological Medical Systems/DoD, contract number W9113M-10-C-0024.

Elusys has completed two safety studies in humans with Anthim and numerous studies demonstrating safety and efficacy in animal models. Anthim has been granted Fast-Track status and Orphan Drug Designation by the FDA.

About Anthim

Anthim is a high-affinity, humanized and deimmunized monoclonal antibody
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SOURCE Elusys Therapeutics, Inc.
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