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Elesclomol Study Shows Significant Improvement in Progression-Free Survival for Chemotherapy-Naive Patients With Metastatic Melanoma
Date:5/20/2008

CHICAGO, May 20 /PRNewswire/ -- GlaxoSmithKline and Synta Pharmaceuticals Corp. (Nasdaq: SNTA) today announced positive Phase II clinical data for elesclomol (formerly STA-4783), an investigational agent currently in development for metastatic melanoma. A retrospective analysis showed that stage IV metastatic melanoma patients treated with elesclomol and paclitaxel who had not previously received chemotherapy had a statistically significant improvement in progression-free survival (PFS) compared to patients who received paclitaxel alone.(1) These data will be presented at the 44th Annual Meeting of the American Society of Clinical Oncology (ASCO) in Chicago. Elesclomol is not yet approved for any indication in any market.

"The incidence of melanoma has continued to rise in recent years and there is an undeniable need to identify effective treatments for patients with metastatic disease," said Paolo Paoletti, M.D., Senior Vice President of the Oncology Medicine Development Center at GSK. "GSK is at the forefront of research to improve the lives of cancer patients, including those with limited treatment options, and we are dedicated to conducting ongoing trials in metastatic melanoma."

"The preliminary clinical data for elesclomol in metastatic melanoma patients are encouraging and underscore the urgent need for new treatments," said Eric Jacobson, M.D., Senior Vice President and Chief Medical Officer, Synta. "These data, combined with earlier clinical and pre-clinical data we have presented for elesclomol, support our belief that oxidative stress induction is a promising new approach to cancer therapy in melanoma and, potentially, other cancer types."

Metastatic melanoma occurs when melanoma - a cancer that begins in m
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SOURCE GlaxoSmithKline; Synta Pharmaceuticals Corp.
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