Navigation Links
Elcelyx Therapeutics Enrolling Phase 2b Trial of NewMet for Type 2 Diabetes
Date:5/20/2013

by targeting the hormone-producing enteroendocrine cells in the lower gut, NewMet may have better tolerability with the preserved efficacy of metformin at a lower dose. This would make NewMet ideal for the millions of Type 2 diabetes patients who have difficulty tolerating metformin or are unable to take the medication due to contraindications. I am eager to see the results of the additional planned clinical studies of NewMet to further understand this attractive profile."

Dr. DeFronzo is a world-renowned clinician, teacher and investigator who led the trials that supported the U.S. Food and Drug Administration approval of metformin in 1994. He and fellow investigators will be presenting the Elcelyx-sponsored NewMet Phase 2a trial results at the 2013 American Diabetes Association Scientific Sessions in June.

This randomized, double-blind, dose-finding Phase 2b trial is evaluating NewMet once-daily doses of 1,000, 800 and 600 milligrams compared to placebo. There are also two comparator arms with generic extended-release metformin dosed once-daily at 1,000 and 2,000 milligrams. The primary endpoint of the study is fasting plasma glucose at 4 weeks of treatment. Secondary endpoints through 12 weeks include changes in fasting plasma glucose, hemoglobin A1c, weight and measures of safety and tolerability. 

"Our research has been eye opening for physicians and endocrinologists who appreciate the clinical benefits of metformin such as glucose control and weight loss but are frustrated by its gastrointestinal side effects, need for titration and exclusion of patients with moderate and severe impaired kidney function. Type 2 diabetes patients who have difficulty tolerating generic metformin either come off of it completely or drop down to a less than maximally effective dose," explained Alain Baron , M.D., President and Chief Executive Officer of Elcelyx Therapeutics. "The goal of this study is to demonstrate that N
'/>"/>

SOURCE Elcelyx Therapeutics
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Elcelyx Therapeutics Names Mark Wiggins Senior Vice President of Business Development, Ginger Graham to Board of Directors
2. Elcelyx Therapeutics Completes $20 Million Series C Financing to Advance NewMet and Lovidia
3. Cell Therapeutics, Inc. (CTI) to Report First Quarter Financial Results on April 20
4. Faruqi & Faruqi, LLP Encourages Investors Who Suffered Substantial Losses Investing in Chelsea Therapeutics International, Ltd. to Contact the Firm
5. Argos Therapeutics Secures $25 million Series D Financing to Commence Phase 3 ADAPT Study in Patients with Metastatic Renal Cell Carcinoma (mRCC) in Mid-2012
6. Novelos Therapeutics Announces Successful Completion of First Cohort In Lung Cancer Trial With I-124-CLR1404 (LIGHT) Cancer-Targeted PET Imaging Agent at UW Carbone Cancer Center
7. Zacks Industry Outlook Highlights: Eli Lilly, Forest Labs, ViroPharma, Novartis and United Therapeutics
8. Oxford BioTherapeutics Appoints Senior Industry Leader to Head its New Clinical Development Operations in Basel, Switzerland
9. Nektar Therapeutics Reports Financial Results for the First Quarter of 2012
10. Cara Therapeutics Licenses Novel Kappa Opioid Agonist, CR845, to Chong Kun Dang Pharmaceutical Corporation For South Korean Market
11. Frost & Sullivan: High Uptake of New Drug Therapies and Aging Population Expansion Keep the U.S. Retinal Therapeutics Market Buoyant
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2015)... 27, 2015 Across the global healthcare landscape, ... in clinical development, market education, and regulatory compliance. As ... Affairs function is expected to increase in prominence and ... According to research by benchmarking firm, Best Practices, ... dedicated to Medical Affairs. Among companies in ...
(Date:3/27/2015)... 2015 /CNW/ - Covalon Technologies Ltd. (the "Company" or ... announced the issuance of an aggregate of 30,000 stock ... an aggregate of 120,500 stock options to employees and ... over three years and will be exercisable for a ... $1.40 per stock option. About Covalon ...
(Date:3/27/2015)... Object recognition technology has a unique and ... The VelaSense ® mobile platform incorporates ... productive and fulfilling lives. VelaSense ® will now ... identify objects from a one million object database, that ... databases for personal use. Visus Technology ...
Breaking Medicine Technology:Medical Affairs Capabilities Expanding in Emerging Marketplaces 2Covalon Announces Issuance of Stock Options 2VelaSense Object Recognition Technology for the Blind was unveiled at Baruch College's CCVIP 8th Annual Conference 2
(Date:3/28/2015)... Emergency Medical Care (EMC), a New ... recently commemorated its three-year anniversary of being the only ... to 24-hour urgent care, Emergency Medical Care offers its ... time, Emergency Medical Care’s Urgent Care NYC ... eye injuries, ear infections, fevers, insect bites, burns, animal ...
(Date:3/28/2015)... 2015 One in three young athletes ... presented today at the American Orthopaedic Society for Sports ... the long term success of surgery for patients aged ... data from 242 patients who underwent ACL reconstruction between ... MBBS, FRACS, from North Sydney Orthopaedic and Sports Medicine ...
(Date:3/28/2015)... March 28, 2015 Andrew Hawley of Vintage ... Who psychedelic concert posters. The Who and the Doors played ... August 2, 1968. According to Hawley, “The Who toured the ... halls and college campuses. Perhaps the most famous Who poster ... Morrison and the Doors on August 2, 1968 at the ...
(Date:3/28/2015)... 28, 2015 Designers and Professionals of ... entitled Scratches 5K from Pixel Film Studios. , “Scratches ... any media inside Final Cut Pro X” Said Christina ... time and is an effective tool for any FCPX ... Scratches 5K's intuitive grunge overlays. Simply drag title layers ...
(Date:3/27/2015)... Miami, FL (PRWEB) March 27, 2015 ... relationship guide from dating experts Samantha Sanderson and Jason ... a frenzied buzz of media attention. The commotion surrounding ... Sean Roman, prompting him to publish an in-depth review ... emotionally devastated when the men in their lives suddenly ...
Breaking Medicine News(10 mins):Health News:Emergency Medical Care Celebrates Three Years of 24/7 Walk-In Urgent Care Services 2Health News:Young Athletes at Greater Risk for Re-Injury after ACL Surgery 2Health News:Avid Collector from Vintage Rock Posters, Inc. Announces His Search For Original 1960's Who Psychedelic Concert Posters. 2Health News:Pixel Film Studios Unveiled Scratches 5k for Final Cut Pro X Editors 2Health News:The Monogamy Method - Review Of Samantha Sanderson & Jason Rogers' Relationship Program Released 2
... St. David,s is Second Hospital Nationwide to Acquire Groundbreaking ... Medical Center today,announced its acquisition of a new robotic ... rhythm disorders that can result in a,stroke. Called the ... technology is only the second to be installed in,the ...
... Tips for Maintaining a Healthy Liver, NEW YORK, ... liver, the American Liver Foundation (ALF) today observed Liver,Awareness ... which affects,30 million Americans. Liver disease, a serious ... 7th leading cause of death among adults between the ...
... HealthSouth,Corporation (NYSE: HLS ) today announced the ... directors, effective Oct. 2, 2007. Mr. Chidsey currently,serves ... Burger King Holdings,Inc. "John brings a strong ... financial operations, capital markets, and corporate,management in a ...
... Budapest, 4 October 2007 -- Last month a collaboration ... against the deadly bird flu virus, harnessing the combined ... to boost the pace of anti-viral drug discovery. , ... ordinary PCs to form a super-sized supercomputer that is ...
... Researchers in the United States and Sweden have identified ... arthritis (RA), a chronic and debilitating inflammatory disease of ... The U.S. arm of the study involved a long-time ... Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and other ...
... Business Services,announced today that they have launched ... and benefits verification. Emdeon is offering these,transactions ... Emdeon suite of,products for dental practices including ... portal. Emdeon Business Services now offers,dental practices ...
Cached Medicine News:Health News:St. David's Medical Center Implements New Robotic Technology to Treat Common Heart Rhythm Disorders 2Health News:St. David's Medical Center Implements New Robotic Technology to Treat Common Heart Rhythm Disorders 3Health News:October is Liver Awareness Month: The American Liver Foundation Urges All Americans to Pay Attention to Their Liver Every Day of the Year 2Health News:October is Liver Awareness Month: The American Liver Foundation Urges All Americans to Pay Attention to Their Liver Every Day of the Year 3Health News:HealthSouth Corporation Appoints New Member to Board of Directors 2Health News:HealthSouth Corporation Appoints New Member to Board of Directors 3Health News:Grid computing offers new hope in race against bird flu 2Health News:Researchers identify genes that increase rheumatoid arthritis risk 2Health News:Researchers identify genes that increase rheumatoid arthritis risk 3Health News:Emdeon Business Services Extends Market Leadership With New Dental Eligibility Payers 2
Thompson surgical radiotranslucent anterior lumbar retractor system....
... Elmed Retract - ... instrument, with extra long ... improved cephalad and anterior ... (Retractor system) was designed ...
... System, a uniquely designed system combining ... two systems into one. Detachable blade ... site during retractor placement, providing better ... retractor body slides easily onto the ...
... device. Rhakoss implants represent the first ... fiber cages and allograft cadaver bone ... of first generation IBFDs while eliminating ... available materials, such as inconsistent structural ...
Medicine Products: