Navigation Links
Elcelyx Therapeutics Enrolling Phase 2b Trial of NewMet for Type 2 Diabetes
Date:5/20/2013

SAN DIEGO, May 20, 2013 /PRNewswire/ -- Enrollment of patients with Type 2 diabetes is underway in Elcelyx Therapeutics' Phase 2b dose-finding clinical trial of product candidate NewMet™, a delayed-release formulation of generic metformin, the foundational treatment for Type 2 diabetes. Elcelyx expects to complete enrollment of 240 patients in the multicenter U.S. program in June. Results of the trial's primary endpoint of change in fasting plasma glucose are expected in late summer, and the read-out for long-term glucose lowering and weight benefits is due in the fourth quarter of 2013.

Elcelyx has not changed the way metformin works but instead, has discovered how and where metformin works and has leveraged that understanding to develop an improved product. Elcelyx believes metformin's primary site of action is the lower bowel rather than the circulation. By targeting the lower bowel, NewMet dramatically reduces the amount of active ingredient in the bloodstream while still maintaining metformin's potent glucose lowering benefit. Phase 2a trial results indicate that a significantly lower once-daily dose of NewMet that maintains efficacy may meaningfully reduce metformin's gastrointestinal side effects and eliminate the need for titration to initiate treatment.

"Elcelyx's approach of reducing bioavailability of metformin is quite ingenious and turns on its head the incorrect belief that greater exposure to metformin is needed for superior therapeutic benefit," said Ralph A. DeFronzo, M.D., Professor of Medicine and Chief of the Diabetes Division at the University of Texas Health Science Center and the Audie L. Murphy Memorial Veterans Administration Hospital in San Antonio, Texas. "Results from previous NewMet trials indicate that
'/>"/>

SOURCE Elcelyx Therapeutics
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Elcelyx Therapeutics Names Mark Wiggins Senior Vice President of Business Development, Ginger Graham to Board of Directors
2. Elcelyx Therapeutics Completes $20 Million Series C Financing to Advance NewMet and Lovidia
3. Cell Therapeutics, Inc. (CTI) to Report First Quarter Financial Results on April 20
4. Faruqi & Faruqi, LLP Encourages Investors Who Suffered Substantial Losses Investing in Chelsea Therapeutics International, Ltd. to Contact the Firm
5. Argos Therapeutics Secures $25 million Series D Financing to Commence Phase 3 ADAPT Study in Patients with Metastatic Renal Cell Carcinoma (mRCC) in Mid-2012
6. Novelos Therapeutics Announces Successful Completion of First Cohort In Lung Cancer Trial With I-124-CLR1404 (LIGHT) Cancer-Targeted PET Imaging Agent at UW Carbone Cancer Center
7. Zacks Industry Outlook Highlights: Eli Lilly, Forest Labs, ViroPharma, Novartis and United Therapeutics
8. Oxford BioTherapeutics Appoints Senior Industry Leader to Head its New Clinical Development Operations in Basel, Switzerland
9. Nektar Therapeutics Reports Financial Results for the First Quarter of 2012
10. Cara Therapeutics Licenses Novel Kappa Opioid Agonist, CR845, to Chong Kun Dang Pharmaceutical Corporation For South Korean Market
11. Frost & Sullivan: High Uptake of New Drug Therapies and Aging Population Expansion Keep the U.S. Retinal Therapeutics Market Buoyant
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... , Oct. 22, 2014  Cephasonics, a technology-innovation ... introduction of the cQUB™-1 (cQuest Ultrasound Box™-1), the first ... systems designed and manufactured by Cephasonics for purchase by ... model number. Cephasonics will be showcasing the cQUB-1 for ... this week in Chongqing, China ...
(Date:10/22/2014)... 2014  Charlene Vernak, RPh, of Vernak Farms Pharmacy ... was awarded the George Roentsch Scholarship by the Professional ... in Houston during PCCA,s International ... annually to an independent pharmacist and PCCA member who ... Roentsch , a well-known pharmacist in the compounding community. ...
(Date:10/22/2014)... Oregon , October 22, 2014 ... "Global Disposable Gloves Market (Product type, Form, End user, ... Profiles, Demand, Insights, Analysis, Research, Report, Opportunities, Segmentation and ... global disposable gloves market. Based on key trends tracked, ... be valued at $7.9 billion by 2020, registering a ...
Breaking Medicine Technology:Cephasonics Launches the cQUB-1, First Product in New Family of cQUB White-Label Ultrasound Systems Targeted at Medical Applications 2Cephasonics Launches the cQUB-1, First Product in New Family of cQUB White-Label Ultrasound Systems Targeted at Medical Applications 3PCCA Awards Charlene Vernak, RPh, the George Roentsch Scholarship 2Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 2Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 3Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 4
... Target-Discovery Program Aimed at New Treatments for Fatal Disease, ... Development,Institute (ALS TDI) today announced that it has completed ... with the profiling of,the SOD1 mouse model of amyotrophic ... phase, profiling of human samples, is,scheduled for completion by ...
... Pharmaceutical,Company Inc. (Nasdaq: NSTK ) announced today ... the Company,s PYY3-36 Nasal Spray in obese patients. ... a six-month,randomized, placebo-controlled dose ranging study with weight ... study design will evaluate three different doses of,Nastech,s ...
Cached Medicine Technology:ALS TDI Completes Gene Expression Profile of Lou Gehrig's Disease in Mice 2ALS TDI Completes Gene Expression Profile of Lou Gehrig's Disease in Mice 3Nastech Pharmaceutical Company Announces Initiation of Phase 2 Clinical Trial for PYY3-36 Nasal Spray to Treat Obesity 2Nastech Pharmaceutical Company Announces Initiation of Phase 2 Clinical Trial for PYY3-36 Nasal Spray to Treat Obesity 3
(Date:10/22/2014)... October 22, 2014 On October 22, ... featuring skin diseases both fictional and real. The ... a nonprofit organization committed to advocacy and philanthropy in ... will take the opportunity to impart truth and clarity ... , There are many misconceptions about Morgellons Disease ...
(Date:10/22/2014)... News) -- The United States is now mandating ... of West Africa land at one of five ... the virus. In a statement released Tuesday, ... percent of air passengers from Guinea, Liberia and ... five airports -- New York City,s Kennedy International ...
(Date:10/22/2014)... OR (PRWEB) October 22, 2014 During ... California’s fresh water supply runs dangerously low, Southern Oregon’s ... Southern Oregon’s rivers, despite the lowest mountain snow pack ... in late summer and early autumn.* That was the ... of the new book “Hiking Southern Oregon,” during an ...
(Date:10/22/2014)... (PRWEB) October 22, 2014 Lintelus, Inc., ... Sr. Vice President of Sales, will be speaking on ... Meetings Technology Expo on October 28, at the Holiday ... hosting a booth as well as a Tech Demo ... Meeting can create a more engaging event experience. , ...
(Date:10/22/2014)... sisters in high school have developed ways to measure ... use electronic stethoscopes, which electronically amplify body sounds, to ... heartbeats. Ilina, a senior at Port Huron Northern ... to detect early lung damage in people exposed to ... one breath cycle each from 16 smokers, 25 nonsmokers ...
Breaking Medicine News(10 mins):Health News:CBS’ Criminal Minds takes aim at skin disease with Morgellons in the Mix 2Health News:CBS’ Criminal Minds takes aim at skin disease with Morgellons in the Mix 3Health News:Passengers From Ebola-Affected Countries Must Land at Designated U.S. Airports 2Health News:Passengers From Ebola-Affected Countries Must Land at Designated U.S. Airports 3Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 2Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 3Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 4Health News:Jay Cormier, Sr. Vice President of Sales for Lintelus, Speaks about Event Technology Integration at Meetings Technology Expo in NYC 2Health News:Teen Sisters Develop Ways to Measure Lung, Heart Damage 2
... disparities in longevity still tied to geography, race and income, ... who smoke, have high blood pressure, high blood sugar and ... average of four years, a new study finds. , In ... while women could be shaving 4.1 years off their lives, ...
... , ... Accreditation Reflect Successful Management of Recent Growth, including ASPCA Pet Health Insurance Program ... Canton, Ohio (PRWEB) ... its subsidiary Petsmarketing Insurance.com Agency, Inc., under three brands, including ASPCA Pet Health Insurance, ...
... ... an increased risk for cardiovascular disease (CVD), namely heart attack and stroke. ... CVD. Nonetheless, there are ways to manage type 2 diabetes and associated ... sponsored by Takeda Pharmaceuticals North America, Inc., was created to help raise ...
... ... expanded its continuum of care with a new licensed assisted living center. Under the direction ... a week. The center,s dedicated nurses and aides provide care and support to residents, helping ... ...
... March 23 E Cigarettes Choice announced today that ... STEALTH, which they originally designed for the military. The STEALTH E-cigarette ... been battle tested in Iraq and Afghanistan ... finish that is difficult to see at night and blends in ...
... , March 23 Last year, the nation ... Cook ,s brother lost their fight with brain tumors. Researchers ... that were designed to kill off residual tumor cells remaining ... tumors. The initial trials of the brain tumor vaccines were ...
Cached Medicine News:Health News:Healthy Living Adds Years to Life 2Health News:Healthy Living Adds Years to Life 3Health News:Healthy Living Adds Years to Life 4Health News:Pet Insurance Provider Hartville Group Gets A+ Rating From Better Business Bureau 2Health News:Pet Insurance Provider Hartville Group Gets A+ Rating From Better Business Bureau 3Health News:The American Heart Association's The Heart of Diabetes Campaign is Helping Patients 'Know Your Diabetes' Better 2Health News:Classic Residence by Hyatt at Teaneck Opens Licensed Assisted Living Center 2Health News:Combat E-Cigarette in Demand by Civilians 2Health News:Combat E-Cigarette in Demand by Civilians 3Health News:Miles for Hope’s Moving Towards A Cure(SM) Brain Tumor Walk in Boston Raising Funds for Brain Tumor Vaccine and Massachusetts General Hospital 2Health News:Miles for Hope’s Moving Towards A Cure(SM) Brain Tumor Walk in Boston Raising Funds for Brain Tumor Vaccine and Massachusetts General Hospital 3Health News:Miles for Hope’s Moving Towards A Cure(SM) Brain Tumor Walk in Boston Raising Funds for Brain Tumor Vaccine and Massachusetts General Hospital 4
Used for drainage and retrograde pyelogram in pediatric patients. A stiffening stylet is included to aid in catheter placement. Supplied sterile in peel-open packages. Intended for one-time use....
... Used for temporary internal drainage ... the bladder. Supplied sterile in ... use. CAUTION: Periodic evaluation is ... stents must not remain indwelling ...
... urethral stenting and to ... hypospadias repair. The stent ... stabilized in the urethra ... at the meatus. Supplied ...
... for temporary internal drainage ... to the bladder. Supplied ... Intended for one-time use. ... advised; C-Flex® and Sof-Flex® ...
Medicine Products: