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Eisai Oncology to Present New Research on Product Portfolio and Pipeline at ASCO Annual Meeting
Date:5/17/2012

er than 7 days or neutropenia with a fever, your next dose of HALAVEN should be delayed and reduced. Severe neutropenia occurred in 57% (287/503) of patients who received HALAVEN and lasted more than 1 week in 12% (62/503) of patients. Neutropenia with a fever occurred in 5% (23/503) of patients; 2 patients died from complications of neutropenia with a fever.  Neutropenia with a fever can result in serious infections that could lead to hospitalization or death. Call your healthcare provider immediately if you have any of the following symptoms; fever (temperature above 100.5 degrees F), chills, coughing, burning or pain when you urinate.

Nerve Disorders (Peripheral Neuropathy)

HALAVEN can cause numbness, tingling, or burning in your hands and feet (peripheral neuropathy). You should be monitored closely for signs of neuropathy.  If you develop severe neuropathy, treatment with HALAVEN should be delayed until the neuropathy improves and the next dose of HALAVEN should be reduced. Severe peripheral neuropathy occurred in 8% (42/503) of patients who received HALAVEN. Neuropathy lasting more than one year occurred in 5% of patients. Twenty-two percent (109/503) of patients developed a new or worsening neuropathy that had not recovered after an average of 269 days.  Peripheral neuropathy was the most common side effect that caused patients to stop receiving HALAVEN.

Pregnancy and Nursing

HALAVEN may harm your unborn baby. Avoid becoming pregnant while you are receiving HALAVEN. Tell your healthcare provider right away if you become pregnant or think you are pregnant while you are receiving HALAVEN. You and your healthcare provider should decide if you will receive HALAVEN or breastfeed. You should not do both.

Heartbeat Changes

HALAVEN can cause changes in your heartbeat (called QTc prolongation). This can cause irregular heartbeats that may lead to death. Your healthcare provider will de
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