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Eisai Oncology to Present New Research on Eribulin at 35th Annual San Antonio Breast Cancer Symposium
Date:11/28/2012

ications of neutropenia with a fever. Neutropenia with a fever can result in serious infections that could lead to hospitalization or death. Patients should call their healthcare provider immediately if they have any of the following symptoms: fever (temperature above 100.5 degrees F), chills, coughing, burning or pain when they urinate.

Nerve Disorders (Peripheral Neuropathy)
Halaven can cause numbness, tingling, or burning in a patient's hands and feet (peripheral neuropathy). A patient should be monitored closely for signs of neuropathy. If a patient develops severe neuropathy, treatment with Halaven should be delayed until the neuropathy improves and the next dose of Halaven should be reduced. Severe peripheral neuropathy occurred in 8% (42/503) of patients who received Halaven. Neuropathy lasting more than one year occurred in 5% of patients. Twenty-two percent (109/503) of patients developed a new or worsening neuropathy that had not recovered after an average of 269 days. Peripheral neuropathy was the most common side effect that caused patients to stop receiving Halaven.

Pregnancy and Nursing
Halaven may harm a patient's unborn baby. A patient should avoid becoming pregnant while they are receiving Halaven. A patient should tell their healthcare provider right away if they become pregnant or think they are pregnant while they are receiving Halaven. The patient and their healthcare provider should decide if they will receive Halaven or breastfeed. A patient should not do both.

Heartbeat Changes
Halaven can cause changes in a patient's heartbeat (called QTc prolongation). This can cause irregular heartbeats that may lead to death. A patient's healthcare provider will decide if they need heart monitoring (electrocardiogram or ECG), or blood tests during their treatment with Halaven to watch for this problem. 

Liver and Kidney Problems
In patients with mild or moderate liver proble
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