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Effient® Added to Updated ACCF/AHA Clinical Guidelines for ACS-PCI Patients with Unstable Angina and Non-ST Segment Myocardial Infarction
Date:3/29/2011

PARSIPPANY, N.J. and INDIANAPOLIS, March 29, 2011 /PRNewswire/ -- Oral antiplatelet therapy Effient® (prasugrel) has been added to the updated clinical practice guidelines as a Class I recommended treatment option for patients undergoing percutaneous coronary intervention (PCI) after experiencing heart-related chest pain at rest (unstable angina) or non-ST segment elevation myocardial infarction (NSTEMI).  NSTEMI is a type of heart attack that that does not need to be treated with emergent opening of a blocked coronary artery.(1) The update to the clinical guidelines, jointly developed by the American College of Cardiology Foundation (ACCF) and the American Heart Association (AHA), was published online on March 28, 2011, in the Journal of the American College of Cardiology and Circulation.

"Class I" means that a given "procedure/treatment should be performed/administered" to patients, given it was found to be "useful/effective/beneficial."  Class I is the highest recommendation provided by the guidelines committee.

Effient tablets are approved by the U.S. Food and Drug Administration to reduce the risk of future heart-related events, such as heart attack or stent thrombosis, in patients with acute coronary syndromes (ACS) who are treated with PCI.  ACS includes heart attack and unstable angina (UA).

The guidelines also include the following recommendations for the use of Effient:

  • Patients with UA or NSTEMI who are at medium to high risk and will have a PCI may be treated with aspirin and Effient at the time of PCI. (Class I recommendation)
  • Patients with UA or NSTEMI who undergo PCI and prescribed Effient should remain on 10 mg of Effient plus aspirin for at least 12 months. (Class I recommendation)
  • A loading dose of 60 mg of Effient may be considered for administration promptly as pre-treatment for a UA/NSTEMI patient for whom PCI is planned, the blee
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SOURCE Daiichi Sankyo Company, Limited; Eli Lilly and Company
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