Navigation Links
Efficacy and Safety Data from Phase 2B Trials of Janssen's Simeprevir in Hepatitis C Patients with Advanced Fibrosis of the Liver Presented at Annual Meeting of the American Association for the Study of Liver Diseases
Date:11/10/2012

g of simeprevir and reporting a Metavir score of F3 (PILLAR), or F3 and F4 (ASPIRE). The Metavir score is used to quantify the degree of inflammation and fibrosis of the liver and patients are scored on a four-point scale. An F3 score means the patient has numerous septa (fibrous tissue bands that can decrease the flow of blood through the liver) without cirrhosis, while an F4 score means the patient has cirrhosis.

About Simeprevir   
Simeprevir (TMC435) is a NS3/4A protease inhibitor jointly developed by Janssen and Medivir AB to treat chronic hepatitis C (HCV). Simeprevir is being studied in combination with pegylated interferon and ribavirin, and in combination with direct-acting antiviral agents in all-oral interferon-free regimens, with and without ribavirin.

Global Phase 3 studies of simeprevir include QUEST-1 and QUEST-2 in treatment-naive patients, PROMISE in patients who have relapsed after prior interferon-based treatment and ATTAIN in null-responder patients.  In parallel to these trials, Phase 3 studies for simeprevir are ongoing in both treatment-naive and treatment-experienced HIV-HCV co-infected patients, HCV genotype 4 patients and in Japanese HCV genotype 1 patients.

Simeprevir is also being studied in Phase 2 interferon-free trials with and without ribavirin in combination with:

  • Janssen's TMC647055 and ritonavir in treatment-naive, relapser or null-responder HCV genotype 1 patients;
  • Gilead Sciences, Inc.'s sofosbuvir (GS-7977) in null-responder HCV genotype 1 patients; and
  • Bristol-Myers Squibb's daclatasvir (BMS-790052) in treatment-naive or previous null-responder HCV genotype 1 patients.

In addition, Janssen recently announced that it has entered into a non-exclusive collaboration with Vertex Pharmaceuticals Incorporated to evaluate in a Phase 2 study the safety and efficacy of an all-oral regimen of simeprevir and Vertex's
'/>"/>

SOURCE Janssen Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. JAMA Study Demonstrates Efficacy of Life Technologies Lung Cancer Test in Detecting Early Metastases, Supports Screening for Lung Cancer
2. Optimization of Comparative Efficacy Trials
3. Sosei Group Corporation: Data at ERS Shows Efficacy of Once-daily COPD Portfolio Versus Comparators, Further Establishes Dual-bronchodilator QVA149
4. Lilly Stops Phase III Development of Pomaglumetad Methionil For the Treatment of Schizophrenia Based on Efficacy Results
5. MedQIA unique CAD algorithm for Quantitation of lung involvement in diffuse lung disease used as treatment efficacy end point in study to be reported at the ERS Annual Conference in Vienna, Austria: September 1-5, 2012
6. Renal Dialysis Equipment Market to 2017- Lower Costs and Similar Efficacy Rates as Hemodialysis to Increase Adoption Rates of Peritoneal Dialysis
7. FDAnews announces Fifth Annual Risk Management & Drug Safety Summit
8. Immunomic Therapeutics Begins Phase I Japanese Red Cedar JRC-LAMP-Vax Vaccine Safety Study
9. Arisaph Pharmaceuticals Reports Positive Results From Two Safety Clinical Trials For Its Niacin Analog (ARI-3037MO)
10. Compounding Pharmacy Safety: Dr. Paul Savage Published in IMJC Post #Meningitis Outbreak
11. Kansas Car Umbrella Encouraged By New Safety Report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... 2014 Creekridge Capital, an independent vendor-focused ... vendors so far in 2014 to their portfolio ... are from both the healthcare and technology industries. ... well-known multi-national companies. Each of these new vendors ... products including: standard leasing products, subscription solutions, a ...
(Date:7/23/2014)... 2014  When it comes to welcoming our new robot ... roll out the red carpet. Healthcare is one ... 9000-like robots into our human sphere. With healthcare concerns top ... need to apply new technologies to help with old problems. ... robotics is expected to increase from $1.7 billion now to ...
(Date:7/23/2014)... , July 23, 2014  Researchers from the North ... calcium elevates calcium levels too high, 1 ... health problems. Women close to menopause are ... D to prevent diseases such as osteoporosis, to which ... that women determine how much calcium they typically get ...
Breaking Medicine Technology:Creekridge Capital Signs Several New Vendor Partners 2Women Taking Too Much Calcium Create Health Risk 2
(Date:7/23/2014)... 2014 (HealthDay News) -- Regularly checking the pulse of ... report. "Screening pulse is the method of choice ... 65 who have never had a stroke. Our study ... easy way to identify people who might need more ... author Dr. Bernd Kallmunzer, of Erlangen University in Germany. ...
(Date:7/23/2014)... of Biomedical Imaging and Bioengineering will host its second ... 2014 on the NIH campus. There will be ten ... breadth of NIBIB-funded research. , WHO: ... Rhodopsins as Optical Voltage Sensor, Quyen Nguyen, Univ. ... Nerve Imaging during Surgery, ...
(Date:7/23/2014)... (PRWEB) July 23, 2014 Global Cardio ... Enhanced External Counterpulsation (EECP), is celebrating the ... EECP therapy at the health center. , Weber ... disease. Since receiving ongoing EECP therapy since 1999, he ... Sara Soulati, CEO of Global Cardio Care, introduced the ...
(Date:7/23/2014)... X syndrome ( FXS ) is a genetic disorder ... on the autistic spectrum, as well as cognitive deficits. ... impairment and the most common cause of autism. , ... have published a study that sheds light ... online today (July 23) in the Journal of ...
(Date:7/23/2014)... Four hospitals affiliated with the ... latest ranking of the country’s best hospitals by ... today and slated for publication in August, the U.S. ... (AGH), Forbes Hospital, Saint Vincent Hospital and West Penn ... specialties. , “There is no higher priority ...
Breaking Medicine News(10 mins):Health News:Routine Pulse Check May Prevent Second Stroke, Study Says 2Health News:Global Cardio Care Celebrates EECP Patient’s 100th Birthday 2Health News:Study links enzyme to autistic behaviors 2Health News:Study links enzyme to autistic behaviors 3Health News:Four Allegheny Health Network Hospitals Named High Performers by U.S. News 2Health News:Four Allegheny Health Network Hospitals Named High Performers by U.S. News 3
... one diagnoses a cancer patient, it,s important to gather as ... have thought an accurate diagnosis would depend on throwing some ... employed by researchers at Rice University and the University of ... of scanners that find and track lung and thoracic tumors. ...
... and salty snacks particularly pervasive, study finds ... you sit in a movie theater with your kid and ... new study that finds popular movies are filled with images ... advertising to children, what,s appropriate and not appropriate, but movies ...
... ... design studio based in Vancouver, Canada, is offering the first collection of ... of modern, European dwellings planned along the principles of Passive Design and ... cooling and building operation than a standard house and up to 50% ...
... The Autism Science ... other stakeholders to support attendance at the International Meeting for Autism Research (IMFAR), to be ... ... organization dedicated to supporting and funding autism research, announced tody that is offering a limited ...
... , Partnership ... Stay Healthy Year-Round , WASHINGTON , Feb. 11 ... by the "Life…supplemented" consumer wellness initiative, close to half ... healthier and they have good intentions, but they may not know ...
... Feb. 11 When the last school bell rings ... down their pencils and papers in favor of video games and ... That,s because children may be picking up something a lot less ... With a summertime stash of Explorer,s Bounty,s Gallop-A-Loozas line of 100% ...
Cached Medicine News:Health News:Less is more in cancer imaging 2Health News:Less is more in cancer imaging 3Health News:Movies Loaded With Images of Junk Food 2Health News:Movies Loaded With Images of Junk Food 3Health News:FAB-HOMES™ Presents First Passive House Collection 2Health News:FAB-HOMES™ Presents First Passive House Collection 3Health News:Autism Science Foundation Offers IMFAR Grants to Autism Stakeholders 2Health News:Autism Science Foundation Offers IMFAR Grants to Autism Stakeholders 3Health News:Helping Turn "WannabeWELLS" into Wise Consumers 2Health News:Helping Turn "WannabeWELLS" into Wise Consumers 3Health News:Helping Turn "WannabeWELLS" into Wise Consumers 4Health News:Helping Turn "WannabeWELLS" into Wise Consumers 5Health News:Helping Turn "WannabeWELLS" into Wise Consumers 6Health News:Explorer's Bounty Puffed Fruit Snacks Helping Parents Battle Summer Obesity 2
... such as laparoscopic inguinal hernia repair ... a surgical biomaterial that enables rapid ... provides the answer to the most ... Made from strong, soft, inert and ...
... is the Bard Kugel Patch, which is constructed ... two layers create a positioning pocket, which is ... position. On the other side is a barrier ... "memory recoil ring," which causes the patch to ...
... patch repair is a minimally invasive, tension-free ... small 4-6 cm incision and requires minimal ... through an open, anterior approach that can ... Modified Kugel patch is a self-expanding polypropylene ...
... Lyra-i system combines the longest available wavelength ... maximize patient safety and efficacy. The unique ... the therapeutic range to all targeted structures. ... ensuring patient safety. All Lyra-I patients are ...
Medicine Products: