Navigation Links
Edison Pharmaceuticals Announces Phase 2 Positive Clinical Results for EPI-743 in Rett Syndrome
Date:9/2/2014

MOUNTAIN VIEW, Calif., Sept. 3, 2014 /PRNewswire/ -- Edison Pharmaceuticals today announced results of a recently completed phase 2 placebo-controlled trial in pediatric patients. Rett syndrome patients treated with EPI-743 demonstrated a statistically significant increase in head circumference.  Decreased brain growth and head circumference are hallmarks of the disease.

Rett syndrome is a genetic neurodevelopmental disorder predominately affecting girls, and is usually diagnosed by 24 months of age. It is characterized by a constellation of neurological, behavioral, functional, and structural features. These include delayed development, characteristic hand wringing, seizures, impaired respiratory function, slowing of brain growth, and resultant diminished head size, as well as other neurological disorders.

The double-blind, placebo-controlled clinical trial was conducted at the General University Hospital (Azienda Ospedaliera Universitaria Senese) of Siena, Italy, a leading international Rett syndrome clinical care and research center. A total of 24 subjects, 2.5 to 8 years of age, were enrolled in the six-month trial. While the study did not meet the primary endpoint of improving the subjective Rett syndrome disease severity score, subjects treated with EPI-743 demonstrated an objective improvement in head growth. Specifically, head growth in the treatment group was 0.75 cm from baseline, compared to 0.29 cm in the placebo group (p=0.05).  In a subgroup analysis of the children with the largest head growth, improvements in oxygenation, hand function, and disease-relevant biomarkers were also recorded. These data will be submitted for publication in the near future.

The natural history of decreased head growth in girls with Rett syndrome has been quantified and is an established metric of disease. Improvement in head growth was recorded in nine of the 12 subjects
'/>"/>

SOURCE Edison Pharmaceuticals, Inc.
Copyright©2014 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Diabecline Antibiotic Receives Edison Award for Best New Pharmaceutical Product
2. Carolinas HealthCare System and Edison Nation Collaborate to Drive Medical Innovation and Technology
3. EMA Grants Orphan Designation to Edison Pharmaceuticals for EPI-743 for Treatment of Leigh Syndrome
4. Edison Pharmaceuticals Announces Positive Results of EPI-743 Phase 2A Leigh Syndrome Clinical Trial
5. Massive Hiring Event for Life Science Professionals in Edison, NJ on 9/18/12
6. Edison Pharmaceuticals Announces Initiation of EPI-743 Phase 2B Leigh Syndrome Clinical Trial
7. Edison Pharmaceuticals Closes $20M Series F Financing
8. Samsung Medison Showcases New Medical Equipment and Technology with Samsung Electronics at RSNA 2012
9. Edison Pharmaceuticals & Bambino Gesu Childrens Hospital Announce Initiation of EPI-743 Phase 2 Cobalamin C Deficiency Syndrome Clinical Trial
10. Edison Pharmaceuticals, Inc. signs licensing agreement with Dainippon Sumitomo Pharma Co., Ltd. for development & commercialization of orphan mitochondrial and adult central nervous system disease drugs
11. Edison Expands North American Healthcare Sector Coverage With Initiation of Coverage on Bellus Health
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2015)... 2015   Cynosure, Inc. (Nasdaq: CYNO ... aesthetic procedures and precision surgical applications worldwide, today reported ... 2015. First-Quarter Highlights: , North America ... earnings of $0.15 per share; GAAP earnings break-even ... 31, 2015 "Cynosure delivered 21 percent year-over-year ...
(Date:5/5/2015)...  Astellas announced that two abstracts detailing clinical data ... data from a study of mirabegron as an add-on ... breaking plenary session at the 2015 annual meeting of ... New Orleans, Louisiana . ... to evaluate enzalutamide compared to bicalutamide in metastatic prostate ...
(Date:5/5/2015)... 5, 2015  AMRI (NASDAQ: AMRI ) today reported ... 31, 2015. Highlights: , First quarter ... , First quarter royalties of $6.7 million, down ... diluted EPS of $0.20 up 25% from $0.16 in 2014, ... current quarter , Completed the acquisitions of ...
Breaking Medicine Technology:Cynosure Announces First-Quarter 2015 Results; Posts Record First-Quarter Revenue of $74.9 Million, Up 21 Percent from Prior Year 2Cynosure Announces First-Quarter 2015 Results; Posts Record First-Quarter Revenue of $74.9 Million, Up 21 Percent from Prior Year 3Cynosure Announces First-Quarter 2015 Results; Posts Record First-Quarter Revenue of $74.9 Million, Up 21 Percent from Prior Year 4Cynosure Announces First-Quarter 2015 Results; Posts Record First-Quarter Revenue of $74.9 Million, Up 21 Percent from Prior Year 5Cynosure Announces First-Quarter 2015 Results; Posts Record First-Quarter Revenue of $74.9 Million, Up 21 Percent from Prior Year 6Cynosure Announces First-Quarter 2015 Results; Posts Record First-Quarter Revenue of $74.9 Million, Up 21 Percent from Prior Year 7Cynosure Announces First-Quarter 2015 Results; Posts Record First-Quarter Revenue of $74.9 Million, Up 21 Percent from Prior Year 8Cynosure Announces First-Quarter 2015 Results; Posts Record First-Quarter Revenue of $74.9 Million, Up 21 Percent from Prior Year 9Cynosure Announces First-Quarter 2015 Results; Posts Record First-Quarter Revenue of $74.9 Million, Up 21 Percent from Prior Year 10Cynosure Announces First-Quarter 2015 Results; Posts Record First-Quarter Revenue of $74.9 Million, Up 21 Percent from Prior Year 11Astellas Announces New Data To Be Presented During Late Breaking Plenary Session At AUA Annual Meeting 2Astellas Announces New Data To Be Presented During Late Breaking Plenary Session At AUA Annual Meeting 3Astellas Announces New Data To Be Presented During Late Breaking Plenary Session At AUA Annual Meeting 4Astellas Announces New Data To Be Presented During Late Breaking Plenary Session At AUA Annual Meeting 5Astellas Announces New Data To Be Presented During Late Breaking Plenary Session At AUA Annual Meeting 6Astellas Announces New Data To Be Presented During Late Breaking Plenary Session At AUA Annual Meeting 7Astellas Announces New Data To Be Presented During Late Breaking Plenary Session At AUA Annual Meeting 8Astellas Announces New Data To Be Presented During Late Breaking Plenary Session At AUA Annual Meeting 9AMRI Announces First Quarter 2015 Results 2AMRI Announces First Quarter 2015 Results 3AMRI Announces First Quarter 2015 Results 4AMRI Announces First Quarter 2015 Results 5AMRI Announces First Quarter 2015 Results 6AMRI Announces First Quarter 2015 Results 7AMRI Announces First Quarter 2015 Results 8AMRI Announces First Quarter 2015 Results 9AMRI Announces First Quarter 2015 Results 10AMRI Announces First Quarter 2015 Results 11AMRI Announces First Quarter 2015 Results 12AMRI Announces First Quarter 2015 Results 13AMRI Announces First Quarter 2015 Results 14AMRI Announces First Quarter 2015 Results 15AMRI Announces First Quarter 2015 Results 16
... SUNNYVALE, Calif., Dec. 22 Arrayit Corporation (OTC Bulletin Board: ... that the Company has made a technological breakthrough in the ... which are tiny glass substrates that contain rows and columns ... The advance allows highly precise printing of as many as ...
... , NEW YORK, Dec. 22 Delcath Systems, Inc. (Nasdaq: ... treatment method for primary and metastatic cancers to the liver, ... Scientific Advisory Board, effective immediately. , "We formed our ... our Delcath PHP System(TM) with insight from the leading experts ...
Cached Medicine Technology:Arrayit Corporation Announces Manufacturing Breakthrough 2Arrayit Corporation Announces Manufacturing Breakthrough 3Professor Riccardo Lencioni Joins Delcath Systems' Scientific Advisory Board 2Professor Riccardo Lencioni Joins Delcath Systems' Scientific Advisory Board 3
(Date:5/5/2015)... Sheltering Arms held its annual benefit ... and Cravath, Swaine & Moore LLP for their philanthropic ... event was co-chaired by Vanguard sponsors Morgan Stanley and ... highlighted Sheltering Arms’ significant growth in New York City ... 2015. Formerly Episcopal Social Services, Sheltering Arms has become ...
(Date:5/5/2015)... 05, 2015 Buckeye Health Plan (BHP) ... CEO and plan president of Buckeye Health Plan. Hill, ... position immediately. , Hill has more than 28 years ... Pacific Northwest, from managed care to large health care ... CEO of HealthPlus of Michigan, a health plan serving ...
(Date:5/5/2015)... NovaSom, Inc., announced today that they will ... Ed Begley Jr., airing via Discovery Channel 3rd QTR ... will focus on NovaSom, a leader in Obstructive Sleep ... AccuSom® home sleep test, which is the only comprehensively ... and next-day test results and interpretation. , ...
(Date:5/5/2015)... After record-breaking sales of Extend Nutrition’s ... Cookies & Cream flavor at stores nationwide this month. ... raised the bar for nutritional snacks. The brand ... nutritional profile, backed by international patents and clinical studies. ... additional new products and expand retail availability throughout 2015. ...
(Date:5/5/2015)... May 05, 2015 After conducting a ... solutions firm B. E. Smith, West Holt Medical ... as chief executive officer. A skilled healthcare executive with ... assume his new duties on June 1st. , “Brad ... well as a keen understanding and success in building ...
Breaking Medicine News(10 mins):Health News:Sheltering Arms Honors Walt "Clyde" Frazier and Cravath, Swaine & Moore LLP at Annual Gala 2Health News:Buckeye Health Plan Announces New Chief Executive Officer 2Health News:Buckeye Health Plan Announces New Chief Executive Officer 3Health News:Innovations with Ed Begley, Jr. to Explore NovaSom, Inc., in Upcoming Episode 2Health News:Nationwide Launch of Extend Nutrition’s Newest Bar Flavors Follows Most Successful New Item Sales in Company History 2Health News:Nationwide Launch of Extend Nutrition’s Newest Bar Flavors Follows Most Successful New Item Sales in Company History 3Health News:Nationwide Launch of Extend Nutrition’s Newest Bar Flavors Follows Most Successful New Item Sales in Company History 4Health News:West Holt Medical Services Hires New Chief Executive Officer 2Health News:West Holt Medical Services Hires New Chief Executive Officer 3
... regain pre-pregnancy body, IRVINE, Calif., Aug. ... post-baby body shaping solution VelaShape(TM),and other medical ... today reveals the results of the VelaShape ... desire to regain their,pre-pregnancy body. Syneron commissioned ...
... host roundtable discussion as part of national ... Campaign for an American Solution, SALT LAKE ... Utah small business owners at a,roundtable discussion on health care issues ... the health insurance industry,s Campaign for,an American Solution, a new national ...
... Gerianne Tringali DiPiano,President, CEO and founder of FemmePharma in ... healthcare executives and one of the top 12 entrepreneurs ... DiPiano is one of only two women., PharmaVOICE ... has not only carved out a niche in the ...
... Texas Mutual Insurance Company,(TMIC) said it would appeal ... the 14th Court of Appeals., The 14th Court ... a,district court in Harris County found TMIC acted in ... insurance code. The jury also had found,that plaintiff P. ...
... for diabetes , , WEDNESDAY, Aug. 27 (HealthDay News) -- Scientists ... insulin-producing beta cells, a feat they call an "extreme makeover." ... or even a cure for both type 1 and type ... production or uptake. , The process, reported online Aug. 27 ...
... Tacoma, Wash. August 27, 2008 Two new ... U.S. military personnel, yet the condition is frequently underdiagnosed. ... journal of the American Headache Society, examine the incidence ... 1-year combat tour in Iraq , as well as ...
Cached Medicine News:Health News:Celebrity Moms' Post-Baby Body Triggers Jealousy, Skepticism in U.S. Moms 2Health News:Celebrity Moms' Post-Baby Body Triggers Jealousy, Skepticism in U.S. Moms 3Health News:Celebrity Moms' Post-Baby Body Triggers Jealousy, Skepticism in U.S. Moms 4Health News:Health Insurance Industry Listens to Health Care Concerns of Utah Small Business Owners 2Health News:Health Insurance Industry Listens to Health Care Concerns of Utah Small Business Owners 3Health News:Texas Mutual Insurance to Appeal 14th Court's Decision to Texas Supreme Court 2Health News:Texas Mutual Insurance to Appeal 14th Court's Decision to Texas Supreme Court 3Health News:Texas Mutual Insurance to Appeal 14th Court's Decision to Texas Supreme Court 4Health News:Pancreatic Cells Turned Into Insulin-Producing Beta Cells 2Health News:Pancreatic Cells Turned Into Insulin-Producing Beta Cells 3Health News:Army personnel show increased risk for migraine 2
Singe-pull lace design provides easy-on application to provide support and immobilization of the wrist while preserving finger mobility...
ManuTrain is an active wrist support that has optional features for increased stabilization....
... Bird and Cronin, Inc. ... of Patient Footwear, Orthopedic ... Care Products. Our products ... quality and available in ...
... 3-Point® Polycentric Hinged Ulnar Deviation Splint uses ... the hand with ulnar deviation at the ... grasp or pinch. Radial and ulnar polycentric ... unimpeded flexion and extension. Padded, malleable finger ...
Medicine Products: