Navigation Links
Edison Pharma Hits Milestone as A0001 Enters Phase 1 Clinical Development
Date:7/14/2008

Targeting inherited mitochondrial diseases as an archetype for diseases of

aging

SAN JOSE, Calif., July 15 /PRNewswire/ -- Edison Pharmaceuticals, Inc., a privately held biotechnology company located in San Jose, CA, announced today that EPI-A0001 (A0001) has entered clinical development, triggering a milestone payment from Penwest Pharmaceuticals, Edison's development partner. Penwest has begun dosing in a Phase 1a clinical trial of A0001, a 2nd generation coenzyme Q10 (CoQ10) analog. It differs from CoQ10 in that it possesses more favorable oral absorption and electron transfer properties.

CoQ10 is a first-line therapy for many rare diseases of energy metabolism. Efforts to improve CoQ10 have centered on improving its oral absorption properties. Edison's focus is on building next-generation CoQ10 analogs through improving its electron transfer, otherwise known as redox, properties. Edison is a leader in the design and development of redox drugs.

Edison's initial therapeutic focus is on rare inherited mitochondrial diseases. Today, there are no FDA- approved treatments for these diseases. CoQ10, and closely related analogs, have been deployed with real, but limited clinical results. Edison's strategy is to improve upon CoQ10's biological activity by optimizing its redox properties. A0001 is the first redox-optimized CoQ10 analog in Edison's clinical development pipeline.

Edison's technical focus is on redox drugs targeting metabolic control and energy metabolism. Children with inherited mitochondrial defects clinically present with many conditions commonly associated with aging. Edison believes that inherited mitochondrial diseases may be genetic roadmaps to deciphering the biochemical basis of metabolic control and aging. Given CoQ10's known role in mitochondrial disease and aging, as well as its redox activity, Edison's initial investigations are focusing on the development of CoQ10 based drugs.

"Today we have reached a key milestone in transforming Edison from a discovery to development-stage company," stated Guy Miller, M.D., Ph.D., Chairman and CEO of Edison. "A0001's entry into Phase 1 is the first step in validating Edison's platform and providing needed therapies for patients suffering from rare mitochondrial diseases. As we look toward the future, we expect to focus our energies on refining our approach to treating rare mitochondrial diseases, and expanding our investigation of redox drugs for the treatment of diseases of aging."

About Edison Pharmaceuticals

Edison Pharmaceuticals, Inc. is a biotechnology company based in Silicon Valley California at the San Jose Biocenter with a specialized knowledge in redox biochemistry and drug design. The company is focused on developing drugs for rare mitochondrial diseases that impair energy metabolism, for which there are no FDA-approved treatments. Edison is leveraging its skills in redox biology and chemistry, and data obtained in its inherited mitochondrial disease programs, to discover new therapeutics for diseases commonly associated with aging.


'/>"/>
SOURCE Edison Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Related medicine technology :

1. MAP Pharmaceuticals Initiates Phase 3 Clinical Trial in Patients With Migraine
2. VIA Pharmaceuticals Completes Patient Visits in Phase 2 Carotid Endarterectomy (CEA) Trial
3. Cerimon Pharmaceuticals Initiates Phase II Study to Evaluate Simulect(R) (Basiliximab) for Noninfectious Uveitis
4. Arena Pharmaceuticals Announces Positive Phase 1b Clinical Trial Results of APD791 for the Treatment of Arterial Thrombosis
5. McGraw-Hill Professional Launches Drug Effectiveness Resource on AccessPharmacy
6. Pharmasset Announces Initiation of Combination Study of Clevudine and Viread(R) for HBV by French National Agency for Research on AIDS and Viral Hepatitis (ANRS)
7. Anadys Pharmaceuticals Resumes Clinical Investigation of TLR7 Mechanism in HCV
8. University of Rochester Researcher Named Millennium Pharmaceuticals Career Development Scholar of The Leukemia & Lymphoma Society
9. Peregrine Pharmaceuticals Reports Positive Early Results in Phase II Study of Bavituximab in Breast Cancer
10. IDM Pharma Provides Update on Mifamurtide (L-MTP-PE) Regulatory Status Following June Meeting of European Committee for Medicinal Products for Human Use (CHMP)
11. Isis Pharmaceuticals Conference Call Notice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... 2016 Amgen (NASDAQ: AMGN ) will present ... Conference at 9:15 a.m. ET on Wednesday, Feb. 10, 2016, ... W. Meline , executive vice president and chief financial officer ... the presentation can be accessed from the Events Calendar on ... the webcast will also be available on Amgen,s website for ...
(Date:2/5/2016)... 2016  Patients in Alabama seeking ... therapy no longer have to travel out of state. ... Urology Centers of Alabama to provide a total ... qualifying patients. Alabama is ... of prostate cancer using many different modalities. They are the ...
(Date:2/5/2016)... York , February 5, 2016 ... Transparency Market Research report states that the global active ... 2014 and is predicted to reach US$185.9 bn by ... of 6.50% from 2014 to 2020. The title of ... Chemical/Biological, Captive/Contract Manufactured, by Geography, and by Therapeutic Area) ...
Breaking Medicine Technology:
(Date:2/5/2016)... ... 2016 , ... US Sports Camps , official operators of Nike Yoga ... kids yoga training. ChildLight Yoga Studio is centrally situated in the picturesque New England ... Yoga Studio founder Lisa Flynn expresses her excitement, “We are thrilled to be partnering ...
(Date:2/5/2016)... ... 2016 , ... The American public tends to feel uncomfortable about drinking recycled ... municipal or well water. The recent experience with lead contaminated water in Flint, Michigan, ... way toward increasing public acceptance of recycled waste water as drinking water. , ...
(Date:2/5/2016)... ... February 05, 2016 , ... Give To Cure today announced that ... donate to Give To Cure’s campaign that is crowdfunding clinical trials to help find ... share payments through a smart device. In 2015 alone, Venmo processed $7.5 billion in ...
(Date:2/5/2016)... ... 2016 , ... Pivot Point Consulting, a leading national Healthcare ... Services for HIT Implementation Support & Staffing report with an outstanding score of ... healthcare executives, managers and clinicians representing over 4,500 hospitals and 2,500 clinics. , ...
(Date:2/5/2016)... ... , ... Dr. Justin Scott and Dr. Lydia Muccioli of Pure Dental ... individuals in need. The event is scheduled to take place on February 27, 2016 ... provide dental care to community members in need. Each patient will be given the ...
Breaking Medicine News(10 mins):