Navigation Links
Edison Pharma Hits Milestone as A0001 Enters Phase 1 Clinical Development
Date:7/14/2008

Targeting inherited mitochondrial diseases as an archetype for diseases of

aging

SAN JOSE, Calif., July 15 /PRNewswire/ -- Edison Pharmaceuticals, Inc., a privately held biotechnology company located in San Jose, CA, announced today that EPI-A0001 (A0001) has entered clinical development, triggering a milestone payment from Penwest Pharmaceuticals, Edison's development partner. Penwest has begun dosing in a Phase 1a clinical trial of A0001, a 2nd generation coenzyme Q10 (CoQ10) analog. It differs from CoQ10 in that it possesses more favorable oral absorption and electron transfer properties.

CoQ10 is a first-line therapy for many rare diseases of energy metabolism. Efforts to improve CoQ10 have centered on improving its oral absorption properties. Edison's focus is on building next-generation CoQ10 analogs through improving its electron transfer, otherwise known as redox, properties. Edison is a leader in the design and development of redox drugs.

Edison's initial therapeutic focus is on rare inherited mitochondrial diseases. Today, there are no FDA- approved treatments for these diseases. CoQ10, and closely related analogs, have been deployed with real, but limited clinical results. Edison's strategy is to improve upon CoQ10's biological activity by optimizing its redox properties. A0001 is the first redox-optimized CoQ10 analog in Edison's clinical development pipeline.

Edison's technical focus is on redox drugs targeting metabolic control and energy metabolism. Children with inherited mitochondrial defects clinically present with many conditions commonly associated with aging. Edison believes that inherited mitochondrial diseases may be genetic roadmaps to deciphering the biochemical basis of metabolic control and aging. Given CoQ10's known role in mitochondrial disease and aging, as well as its redox activity, Edison's initial investigations are focusing on the development of CoQ10 based drugs.
'/>"/>

SOURCE Edison Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. MAP Pharmaceuticals Initiates Phase 3 Clinical Trial in Patients With Migraine
2. VIA Pharmaceuticals Completes Patient Visits in Phase 2 Carotid Endarterectomy (CEA) Trial
3. Cerimon Pharmaceuticals Initiates Phase II Study to Evaluate Simulect(R) (Basiliximab) for Noninfectious Uveitis
4. Arena Pharmaceuticals Announces Positive Phase 1b Clinical Trial Results of APD791 for the Treatment of Arterial Thrombosis
5. McGraw-Hill Professional Launches Drug Effectiveness Resource on AccessPharmacy
6. Pharmasset Announces Initiation of Combination Study of Clevudine and Viread(R) for HBV by French National Agency for Research on AIDS and Viral Hepatitis (ANRS)
7. Anadys Pharmaceuticals Resumes Clinical Investigation of TLR7 Mechanism in HCV
8. University of Rochester Researcher Named Millennium Pharmaceuticals Career Development Scholar of The Leukemia & Lymphoma Society
9. Peregrine Pharmaceuticals Reports Positive Early Results in Phase II Study of Bavituximab in Breast Cancer
10. IDM Pharma Provides Update on Mifamurtide (L-MTP-PE) Regulatory Status Following June Meeting of European Committee for Medicinal Products for Human Use (CHMP)
11. Isis Pharmaceuticals Conference Call Notice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... Aug. 20, 2014  The National Association of ... results achieved by the real-time, pseudoephedrine (PSE) blocking ... Precursor Log Exchange (NPLEx), automatically blocks unlawful PSE ... meth offenders and make arrests. Data released by ... blocked the sale of more than ...
(Date:8/20/2014)... , Aug. 20, 2014 The ... lauded the latest results achieved by the real-time, ... as the National Precursor Log Exchange (NPLEx), automatically ... officials track down meth offenders and make arrests. ... Kansas blocked the sale ...
(Date:8/20/2014)... , Aug. 20, 2014  The National Association ... latest results achieved by the real-time, pseudoephedrine (PSE) ... National Precursor Log Exchange (NPLEx), automatically blocks unlawful ... down methamphetamine offenders and make arrests. Data released ... Michigan blocked the sale of more ...
Breaking Medicine Technology:Indiana's Stop-Sale System Achieves Significant Results In Battle Against Meth 2Kansas's Stop-Sale System Achieves Significant Results In Battle Against Meth 2Michigan's Stop-Sale System Achieves Significant Results In Battle Against Meth 2
... NEW YORK, Feb. 22, 2011 Reportlinker.com announces ... in its catalogue: Global ... http://www.reportlinker.com/p098382/Global-Orthopedic-Instrumentation-Industry.html This report analyzes the ... by the following Product Segments: Reconstructive Sector (Hip ...
... 2011 Reportlinker.com announces that a new market ... Global Gelatin Industry ... the worldwide markets for Gelatin in Thousand Metric ... & Beverage, Pharmaceutical, Photographic Supplies, and Others. The ...
Cached Medicine Technology:Reportlinker Adds Global Orthopedic Instrumentation Industry 2
(Date:8/21/2014)... 2014 According to a new market ... (Product Types - Home Theatre in-a-box, Home audio systems, ... Industry Analysis, Size, Share, Growth, Trends and Forecast, 2013 ... billion in 2012 and is expected to reach USD ... 3.7% from 2013 to 2019. Europe was the largest ...
(Date:8/21/2014)... Revista, a one-stop source for ... data, is “on a roll.” Today, the Annapolis-based ... the Southeast, Mid-Atlantic and Midwest areas of the ... widely available, comprehensive medical property database tracking these ... properties, including existing and recently added, is 34,549. ...
(Date:8/21/2014)... American Addiction Centers, a leading national provider of ... and/or alcohol addiction, has been named to the Inc. ... The company is ranked 7th on the “Top 20 ... the list in the “Nashville Metro Area” sub-category. With ... Centers (AAC) ascended to number 474 on the larger ...
(Date:8/21/2014)... Steven Reinberg HealthDay Reporter ... U.S. teens using sunscreen dropped nearly 12 percent in the ... time period, the number of teens using indoor tanning beds ... increase the risk of skin cancers, including deadly melanomas, the ... overall percentage of teens who reported wearing sunscreen, from 67.7 ...
(Date:8/21/2014)... 2014 Sasha is a 10 year old ... getting a little older, and is having trouble getting up ... happens to have an owner who purchased a Butler Mobility ... accident, and could no longer get up and down the ... basement. She had tried a stair lift, but had ...
Breaking Medicine News(10 mins):Health News:Home Audio Equipment Market Expected to Reach USD 20.68 Billion in 2019 2Health News:Home Audio Equipment Market Expected to Reach USD 20.68 Billion in 2019 3Health News:Revista Medical Property Data Now Available for the Mid-Atlantic, Southeast and Midwest Regions 2Health News:Revista Medical Property Data Now Available for the Mid-Atlantic, Southeast and Midwest Regions 3Health News:Revista Medical Property Data Now Available for the Mid-Atlantic, Southeast and Midwest Regions 4Health News:Revista Medical Property Data Now Available for the Mid-Atlantic, Southeast and Midwest Regions 5Health News:American Addiction Centers Named to Inc. 500 List Recognition for Three-Year Sales Growth of 995% 2Health News:Fewer U.S. Teens Using Sunscreen, Study Finds 2Health News:Sasha Gets a Butler Mobility Inclined Platform Lift 2
... VASNM and the International Partnership for Critical Markers ... on Friday, May 1, 2009, examining FDA requirements ... meeting, which takes place at the Natcher Auditorium, ... to begin at 6:10 p.m. and conclude at ...
... Offers Top-Tier Developers And Designers Powerful New Brainwave-Based ... 26 As the videogame industry defies the ... to create the next generation of best-selling games ... that leads the global field in neuromarketing, has ...
... 26 A new ad campaign from Dakim, Inc. ... is not retired" and "My mind is in your ... dementia-fighting brain fitness tools in senior living communities. The ... #1-selling senior-focused brain training system that has been adopted ...
... Coalition to Protect Senior Care -- a national coalition ... nursing care -- commended the Senate Finance Health Subcommittee ... term care in any comprehensive health care reform plan ... Care in Health Reform." "Speaking on behalf of the ...
... Kennedy and Kay Bailey Hutchison introduced legislation that ... and advancing the national cancer program of the ... (Access to Life-saving Early detection, Research and Treatment) ... national cancer program and improve cancer research, prevention, ...
... Patients facing open heart surgery ... some great news: open heart surgery doesn,t have ... surgeon at Saint Joseph,s Hospital in Atlanta and the ... bypass surgery, has started performing the procedures in Georgia. ...
Cached Medicine News:Health News:Meeting to examine FDA requirements for manufacturing PET radiopharmaceuticals 2Health News:Meeting to examine FDA requirements for manufacturing PET radiopharmaceuticals 3Health News:NeuroFocus Launches NGame; New Suite of Neuromarketing Products and Services for the Videogame Industry Elite 2Health News:NeuroFocus Launches NGame; New Suite of Neuromarketing Products and Services for the Videogame Industry Elite 3Health News:New Dakim Campaign Promotes Brain Fitness for Seniors with Elderly Holding Signs Declaring 'My Brain Is Not Retired' 2Health News:New Dakim Campaign Promotes Brain Fitness for Seniors with Elderly Holding Signs Declaring 'My Brain Is Not Retired' 3Health News:Coalition to Protect Senior Care Applauds Senate Finance Health Subcommittee Hearing on Long Term Care Improvement as Part of Broad Health Care Reform 2Health News:The AACR commends Senators Kennedy and Hutchison on the 21st Century Cancer ALERT Act 2Health News:Closing Open Heart Surgery: Saint Joseph's Performs Georgia's First Totally-Closed, Beating Heart Bypass Surgery 2
10 plate suitable for children and the illiterate....
Accepted by leading authorities as a simple and accurate method for discovering congenital color blindness of two type total color blindness and red/green blindness. This book is used for children an...
Stainless steel disposable retinal MVR blade, 10 pcs / box....
Lens Plus Daily Cleaner is the preservative-free daily cleaner for soft contact lenses....
Medicine Products: