Navigation Links
Edison Pharma Hits Milestone as A0001 Enters Phase 1 Clinical Development
Date:7/14/2008

Targeting inherited mitochondrial diseases as an archetype for diseases of

aging

SAN JOSE, Calif., July 15 /PRNewswire/ -- Edison Pharmaceuticals, Inc., a privately held biotechnology company located in San Jose, CA, announced today that EPI-A0001 (A0001) has entered clinical development, triggering a milestone payment from Penwest Pharmaceuticals, Edison's development partner. Penwest has begun dosing in a Phase 1a clinical trial of A0001, a 2nd generation coenzyme Q10 (CoQ10) analog. It differs from CoQ10 in that it possesses more favorable oral absorption and electron transfer properties.

CoQ10 is a first-line therapy for many rare diseases of energy metabolism. Efforts to improve CoQ10 have centered on improving its oral absorption properties. Edison's focus is on building next-generation CoQ10 analogs through improving its electron transfer, otherwise known as redox, properties. Edison is a leader in the design and development of redox drugs.

Edison's initial therapeutic focus is on rare inherited mitochondrial diseases. Today, there are no FDA- approved treatments for these diseases. CoQ10, and closely related analogs, have been deployed with real, but limited clinical results. Edison's strategy is to improve upon CoQ10's biological activity by optimizing its redox properties. A0001 is the first redox-optimized CoQ10 analog in Edison's clinical development pipeline.

Edison's technical focus is on redox drugs targeting metabolic control and energy metabolism. Children with inherited mitochondrial defects clinically present with many conditions commonly associated with aging. Edison believes that inherited mitochondrial diseases may be genetic roadmaps to deciphering the biochemical basis of metabolic control and aging. Given CoQ10's known role in mitochondrial disease and aging, as well as its redox activity, Edison's initial investigations are focusing on the development of CoQ10 based drugs.
'/>"/>

SOURCE Edison Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. MAP Pharmaceuticals Initiates Phase 3 Clinical Trial in Patients With Migraine
2. VIA Pharmaceuticals Completes Patient Visits in Phase 2 Carotid Endarterectomy (CEA) Trial
3. Cerimon Pharmaceuticals Initiates Phase II Study to Evaluate Simulect(R) (Basiliximab) for Noninfectious Uveitis
4. Arena Pharmaceuticals Announces Positive Phase 1b Clinical Trial Results of APD791 for the Treatment of Arterial Thrombosis
5. McGraw-Hill Professional Launches Drug Effectiveness Resource on AccessPharmacy
6. Pharmasset Announces Initiation of Combination Study of Clevudine and Viread(R) for HBV by French National Agency for Research on AIDS and Viral Hepatitis (ANRS)
7. Anadys Pharmaceuticals Resumes Clinical Investigation of TLR7 Mechanism in HCV
8. University of Rochester Researcher Named Millennium Pharmaceuticals Career Development Scholar of The Leukemia & Lymphoma Society
9. Peregrine Pharmaceuticals Reports Positive Early Results in Phase II Study of Bavituximab in Breast Cancer
10. IDM Pharma Provides Update on Mifamurtide (L-MTP-PE) Regulatory Status Following June Meeting of European Committee for Medicinal Products for Human Use (CHMP)
11. Isis Pharmaceuticals Conference Call Notice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/29/2014)... SAN DIEGO , 29 septembre ... désignée Daiichi Sankyo) (TSE : 4568) et Ambit Biosciences ... d,un accord de fusion définitif en vertu duquel ... actions ordinaires en circulation d,Ambit Biosciences à 15 ... d,une offre publique d,achat qui sera suivie d,une ...
(Date:9/29/2014)...  Bob Pack, who lost his two young children ... Medical Association to immediately cease airing a television ad ... Mercury News called "shamelessly deceptive" and of which the ... believe about the measure is wrong." ... that doctors check California,s existing ...
(Date:9/29/2014)... Sept. 29, 2014  Volcano Corporation (Nasdaq: ... improving patient and economic outcomes on a global ... coronary and peripheral visualization, physiology diagnostics and therapies, ... Board of Directors from Engaged Capital, LLC.  The ... Volcano welcomes the perspectives of its ...
Breaking Medicine Technology:Daiichi Sankyo va acquérir Ambit Biosciences 2Daiichi Sankyo va acquérir Ambit Biosciences 3Daiichi Sankyo va acquérir Ambit Biosciences 4Daiichi Sankyo va acquérir Ambit Biosciences 5Daiichi Sankyo va acquérir Ambit Biosciences 6Daiichi Sankyo va acquérir Ambit Biosciences 7Daiichi Sankyo va acquérir Ambit Biosciences 8Daiichi Sankyo va acquérir Ambit Biosciences 9Father Calls On CA Medical Assn To Pull TV Ad Called "Jaw-Droppingly Deceptive" and "Baloney" By LA Times & "Shamelessly Deceptive" By San Jose Mercury News, Says Consumer Watchdog Campaign 2Father Calls On CA Medical Assn To Pull TV Ad Called "Jaw-Droppingly Deceptive" and "Baloney" By LA Times & "Shamelessly Deceptive" By San Jose Mercury News, Says Consumer Watchdog Campaign 3Father Calls On CA Medical Assn To Pull TV Ad Called "Jaw-Droppingly Deceptive" and "Baloney" By LA Times & "Shamelessly Deceptive" By San Jose Mercury News, Says Consumer Watchdog Campaign 4Father Calls On CA Medical Assn To Pull TV Ad Called "Jaw-Droppingly Deceptive" and "Baloney" By LA Times & "Shamelessly Deceptive" By San Jose Mercury News, Says Consumer Watchdog Campaign 5Volcano Issues Statement Regarding Letter From Engaged Capital 2Volcano Issues Statement Regarding Letter From Engaged Capital 3
... studied the treatment of pregnant women with hepatitis B virus ... study concluded that both the mothers benefited from treatment and ... weeks postbirth. The study presenter and co-investigator Calvin ... as hepatitis B is difficult to eradicate and currently there ...
... POINT, Calif., Nov. 1, 2010 The Global ... organization that aims to raise awareness about the ... 7,000 Bracelets for Hope™ campaign. The 7,000 Bracelets ... to an estimated 7,000 different chronic, life-threatening and ...
Cached Medicine Technology:Telbivudine Given to Mothers With Hepatitis B Reduces Infection Rate in Infants 2Telbivudine Given to Mothers With Hepatitis B Reduces Infection Rate in Infants 37,000 Bracelets For Hope™ - A Rare Disease Awareness Campaign 27,000 Bracelets For Hope™ - A Rare Disease Awareness Campaign 3
(Date:9/30/2014)... Seattle, WA (PRWEB) September 30, 2014 ... Intelligence, proudly announced today that the Department of ... Office as its Enterprise End User Business ... to better support our nation’s veterans by enabling ... obtained through BI Office’s powerful enterprise analytics and ...
(Date:9/30/2014)... September 30, 2014 “Biology and ... Bryan W. Brickner, “and it’s about naming rights.” ... Science , new on the Bryan William Brickner ... the National Institutes of Health (PubMed). The post ... sleep disturbances, REM transitions, aging with THC, the ...
(Date:9/30/2014)... A trailblazer at heart, Dr. Scott Katzman stays ... breakthroughs in spine repairs. His newest appreciation has been ... in which he has implanted the Mobi-C Artificial Disc ... art and mimic normal human disc motion. Dr. Katzman goes ... to be an exceptional replacement device for failing fusions. Patients ...
(Date:9/30/2014)... 3M has added four new thin VHB products to ... 5906 , 3M 5907 , 3M 5908 , ... create the strongest bond possible to a wide range of ... difficult surfaces such as paints, low surface energy plastics, and ... are designed specifically for electronic device engineers and electronics manufacturers. ...
(Date:9/30/2014)... RI (PRWEB) September 30, 2014 Dogs are ... Oftentimes, this involves spending time in the car travelling from ... canines have free run of the vehicle; however, this is ... owner as well. Royal Flush Havanese shares with ... always be routine practice. , There are many ways a ...
Breaking Medicine News(10 mins):Health News:U.S. Department of Veterans Affairs Takes Its Analytic Capabilities to the Next Level with BI Office from Pyramid Analytics 2Health News:Homeostasis: Publius’ Sleep Political Cannabinoid Science ~ New on the Bryan William Brickner Blog 2Health News:3M Releases New VHB™ Thin Foam Tapes as the Ultimate Electronics Bonding Solution 2Health News:3M Releases New VHB™ Thin Foam Tapes as the Ultimate Electronics Bonding Solution 3Health News:Royal Flush Havanese Offers Tops On the Importance of Restraining Dogs In Cars 2Health News:Royal Flush Havanese Offers Tops On the Importance of Restraining Dogs In Cars 3
... , The 10th Annual Conference and Exposition of ... Society for Human Resource Management --HR: Building Bridges to Success" in ... July 23-24 , , ... that employee wellness programs that help workers lose weight or quit smoking, for instance, ...
... MUMBAI, July 23 , ... Activity by the Clinical Investigator Dr. A Bhattacharya Working,at the GG ... - Glenmark Not Only Acts as the Whistle-Blower but Also ... After receiving approval from the Drug Controller General of India(DCGI),for ...
... 23 /PRNewswire-Asia-FirstCall/ -- 3SBio Inc.,(Nasdaq: SSRX ), ... and marketing biopharmaceutical,products, today announced that it will release ... after the US market closes on Tuesday,August 11, 2009. ... 3SBio,s senior management will host a,conference call at 5:00 ...
... ... classes. As a special promotion eMindful is offering unlimited classes for the month of ... yoga practice, or has wanted to explore the health benefits of yoga, to participate at ... ...
... ... dentist Dr. Robert L. Williamson one of America,s Top Dentists. , ... Raleigh, North Carolina (PRWEB) July 23, 2009 -- For ... award for being one of the top dentists in the United States. The Consumer,s Research ...
... ... top Orthopedic Surgeons in the greater Atlanta metro area for the second consecutive time. ... skilled, exceptional, and ,most-trusted, sports medicine specialist. , ... Atlanta, GA (PRWEB) July 23, 2009 -- Spero G. Karas M.D. ...
Cached Medicine News:Health News:Employee Wellness Programs Demonstrate Positive Return on Investment for Businesses 2Health News:Employee Wellness Programs Demonstrate Positive Return on Investment for Businesses 3Health News:Glenmark Brings to the Notice of the Authorities Irregularities of the Clinical Investigator at its Jamnagar Site in Gujarat 2Health News:3SBio Inc. to Report 2009 Second Quarter Earnings on August 11, 2009 2Health News:3SBio Inc. to Report 2009 Second Quarter Earnings on August 11, 2009 3Health News:eMindful.com Launches Live, Interactive Online Yoga Classes 2Health News:eMindful.com Launches Live, Interactive Online Yoga Classes 3Health News:Dr. Robert L. Williamson III Once Again Selected As One of America's Top Dentists 2Health News:Atlanta Sports Medicine Doctor Spero Karas Wins 'Atlanta's Top Doctors' Honor Again 2Health News:Atlanta Sports Medicine Doctor Spero Karas Wins 'Atlanta's Top Doctors' Honor Again 3
... Aplicare's Saturated Swabsticks are packaged ... Each 4 inch Swabstick is saturated ... solution. Each package is terminally sterilized, ... the patient. It acts as a ...
... Antiseptic Antibacterial that does not ... 30 seconds, destroys over 99% ... for cleansing of minor wounds, ... disinfection of personal utensils and ...
... professional degerming, pre-op and post-op procedures. ... quaternary and substituted phenolic active ingredients ... and surfactants. Unprecedented efficacy on all ... 30 seconds. Techni-Care represents a new ...
Aplicare's disposable 1-ounce pouches are designed for individual application and are ideal for reducing waste. They are used in nursing homes, home healthcare settings, blood banks, laboratories, em...
Medicine Products: