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Echo Therapeutics Announces Positive Results of a Clinical Study of its Symphony(TM) Transdermal Continuous Glucose Monitoring System in Patients with Type 1 and Type 2 Diabetes
Date:7/29/2008

glucometers. The Clarke error grid is a plot of all data pairs categorized into five discrete areas: A, B, C, D and E. The A and B areas are the most clinically desirable zones and D and E are the least clinically desirable zones. Devices with a higher combined A and B zone percentage (closer to 100%) and lower combined D and E zone percentage (closer to 0%) are considered to have better performance. Continuous Glucose Monitoring (CGM) system performance, including tCGM system performance, is competitive if at least ninety-five percent (95%) of the data points fall within the combined A/B zones, along with negligible or no data points in the combined D/E zones. Mean absolute relative difference (MARD) is a standard error calculation tool that is used to measure the average absolute value of the relative (or percentage) difference between two measurements. A low MARD error, below 20%, is generally considered competitive.

Study Results

Using 1,292 reference blood glucose measurements from the ten subjects in the study, Clarke error grid analysis of the study data showed that Echo's Symphony tCGM System had approximately 99% of the data in the combined A/B zones, with 76.4% in the A zone and 22.4% in the B zone, and only 0.2% and 0.9% in the C zone and D zone, respectively. The MARD for the study was 13.8%. The correlation coefficient (R) for the data was 0.89. There were no adverse events reported from Prelude skin permeation or the Symphony tCGM biosensor.

Conference Call and Webcast Information

Echo will host a conference call today at 11:00 AM ET to discuss the data from its recent clinical study and to provide an update on its Symphony development program. To access the conference call, please dial 866-394-4716 (domestic) or 706-634-5164 (international) and reference the conference ID 58102479. A replay of the call will be available from 12:00 PM. ET on July 29, until August 12, 2008, at midnight. To access the replay, please dial 800-6
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SOURCE Echo Therapeutics
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