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Early Switch from IV to Oral Meds Is Effective for Children with Acute Bone Infection
Date:2/12/2009

1 children receiving the prolonged IV antibiotic had to return to the hospital for further treatment, compared to 4 percent of the 948 children receiving oral medicine. "The risk of treatment failure was not significantly different between the two groups," said Zaoutis. "But approximately 4 percent of the children receiving the prolonged IV therapy had complications related to the central venous catheter."

Zaoutis's study found wide variability in hospital practices, with some children's hospitals switching over 90 percent of their osteomyelitis patients to oral drugs, and other hospitals using early transition in less than 10 percent of patients. "This study provides evidence that hospitals can orient their clinical guidelines toward early transition to oral medication for acute osteomyelitis in children," added Zaoutis. He cautioned that the study focused on children with uncomplicated infections, and switching to oral therapy may not be appropriate for complicated infections or chronic osteomyelitis.

Zaoutis receives support from the National Institutes of Health, and the Agency for Healthcare Research and Quality provided grant support for this research. Zaoutis's co-authors were Ron Keren, M.D., M.P.H., A. Russell Localio, Ph.D., Kateri Leckerman, M.S., and Stephanie Saddlemire, M.S.P.H., all of Children's Hospital; and David Bertoch, M.H.A., of the Child Health Corporation of America, Shawnee Mission, Kans. Zaoutis, Localio, and Keren also are on the faculty of the University of Pennsylvania School of Medicine.

About The Children's Hospital of Philadelphia: The Children's Hospital of Philadelphia was founded in 1855 as the nation's first pediatric hospital. Through its long-standing commitment to providing exceptional patient care, training new generations of pediatric healthcare professionals and pioneering major research initiatives, Children's Hospital has fostered many discoveries that have bene
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SOURCE The Children's Hospital of Philadelphia
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