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Early Research Suggests Umbilical Cord Blood Cell Therapy May Reduce Progression of Alzheimer's Disease
Date:3/27/2008

urodegenerative and other chronic conditions," said Mercedes Walton, Chairman and CEO, Cryo-Cell International. "Cryo-Cell is committed to supporting this important research, in addition to leading groundbreaking studies of our own to explore the potential of non- controversial stem cells. We are encouraged by studies that continue to reaffirm the benefit of cord blood, and the value of storing one's own cord blood for future use."

About the Study

During the study, researchers administered a series of low-dose infusions of umbilical cord blood cells into mice with abnormalities mimicking Alzheimer's disease. As they observed the mice, they found that the levels of amyloid-beta proteins, which are key markers of Alzheimer's progression in the brain, were reduced by nearly two-thirds (62%), and cerebral amyloid angiopathy (CAA, another marker of the disease in which the amyloid proteins harden the brain's blood vessel walls) was improved by 86 percent. The cord blood infusions were shown to suppress the inflammatory activity, which indicates their potential to block the inflammatory response involved in Alzheimer's disease and also related disorders.

Importantly, these reductions were associated with managing circulating and brain soluble CD40L levels, amino acids that are key contributors to brain inflammation and disease progression. Previous research has suggested that blocking CD40L levels can help minimize amyloid protein activity, improve cognition and manage disease progression in Alzheimer's models. The study concluded that the therapy may alleviate several important pathological changes in the brain associated with Alzheimer's disease, and should be studied further in human trials to fully understand its potential.

"We are looking closely at how stem cells can benefit particular conditions that involve degeneration of tissue, including Alzheimer's disease," said Cyndy Sanberg, Ph.D., Vice President, Research and Development for San
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SOURCE Cryo-Cell International, Inc.
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