Navigation Links
Early Data Show Potential for Imatinib Mesylate Tablets to Treat Life-Threatening Form of Pulmonary Artery Disease
Date:10/8/2008

CYP2C9. Dosage of Gleevec should increase by at least 50%, and clinical response should be carefully monitored, in patients receiving Gleevec with a potent CYP3A4 inducer such as rifampin or phenytoin. Examples of commonly used drugs that may significantly interact with Gleevec include ketoconazole, acetaminophen, warfarin, erythromycin and phenytoin. (Please see full Prescribing Information for other potential drug interactions).

For daily dosing of 800 mg and above, dosing should be accomplished using the 400 mg tablets to reduce exposure to iron.

Common side effects of Gleevec tablets

The majority of adult Ph+ CML patients who received Gleevec in clinical studies experienced adverse reactions at some time, but most were mild to moderate in severity. The most frequently reported adverse reactions (all Grades) were superficial edema (60%-74%), nausea (50%-73%), muscle cramps (28%-62%), vomiting (23%-58%), diarrhea (43%-57%), musculoskeletal pain (38%-49%) and rash and related terms (36%-47%).(+)(++)

The overall safety profile of Ph+ CML pediatric patients treated with Gleevec in 93 children studied was similar to that found in studies with adult patients, except that musculoskeletal pain was less frequent (20.5%) and peripheral edema was not reported. Nausea and vomiting were the most commonly reported individual adverse reactions with an incidence similar to that seen in adult patients.

The adverse reactions and safety profile for Ph+ ALL, MDS/MPD, ASM and HES/CEL were generally similar to the safety profile for Ph+ CML.

The most frequently reported drug-related adverse reactions reported in the Ph+ ALL studies were mild nausea, vomiting, diarrhea, myalgia, muscle cramps and rash, which were easily manageable. Superficial edemas were also a common finding in all studies and were described primarily as periorbital or lower-limb edemas. However, these edemas were rarely severe and may be managed with diuretics, other support
'/>"/>

SOURCE Novartis Pharmaceuticals Corporation
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10 11 12

Related medicine technology :

1. BioView Reports Interim Results of Early Detection Lung Cancer Diagnostic Test
2. Physicians Estimate That if Approved, Ceftobiprole Will Steal Nearly a Third of Zyvoxs Patient Share in the Treatment of Nosocomial Pneumonia
3. Five-Year Data Confirm That Early Treatment with Betaseron(R) at First Sign of Disease Can Delay Progression to MS
4. New Data Presented at WCTRIMS* Supports the Importance of Early and Sustained Treatment with Betaseron(R)
5. Electronic Brachytherapy a Viable Option for Early Stage Breast Cancer, According to Study Presented at ASCO Breast Cancer Symposium
6. K-State Researchers Awarded Nearly $1 Million to Test Remedies, Investigate Link Between E. Coli and Distillers Grains
7. Markers in Blood and Spinal Fluid, and a New Imaging Agent, Show Promise for Early Detection of Alzheimers
8. Snapshots of Eyes Could Serve as Early Warning of Diabetes or Diabetic Eye Disease, U-M Researchers Report
9. Eight-Year Melanoma Remission is Among Early Cancer Treatment Results
10. Head-to-Head Study Demonstrates Focalin(R) XR Offers Faster and Better Symptom Control than Concerta(R)1 in Early Part of ADHD Patients Day
11. Peregrine Pharmaceuticals Reports Positive Early Results in Phase II Study of Bavituximab in Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... , June 30, 2015 Pulse ... issued a survey to Rosacea sufferers as part of their ... treatments Rosacea sufferers found effective for their Rosacea. The survey ... and comprised 47% men and 53% women. The ... survey participants did not consider or attempt to visit their ...
(Date:6/30/2015)... First Choice Wellness Care recently upgraded their ... is the only clinic in the greater ... The practice has recently expanded their services and added ... their focus in the procedure. They upgraded to the ... clearance, and superior service. "We,ve been providing ...
(Date:6/30/2015)... ALISO VIEJO, Calif. , June 30, 2015 ... from the PRISM II study showing that treatment ... statistically significant reduction in symptoms of pseudobulbar affect ... or stroke. PBA is a distressing condition characterized ... crying resulting from certain neurologic diseases or brain ...
Breaking Medicine Technology:84% of Rosacea Sufferers Say NHS Treatments Were "Ineffective" New Survey Reveals 284% of Rosacea Sufferers Say NHS Treatments Were "Ineffective" New Survey Reveals 3First Choice Wellness Care Becomes Tallahassee Leader In Tattoo Removal With Astanza Duality 2First Choice Wellness Care Becomes Tallahassee Leader In Tattoo Removal With Astanza Duality 3Avanir Pharmaceuticals Announces Positive Top-line Results from Stroke and TBI Cohorts of PRISM II Study 2Avanir Pharmaceuticals Announces Positive Top-line Results from Stroke and TBI Cohorts of PRISM II Study 3Avanir Pharmaceuticals Announces Positive Top-line Results from Stroke and TBI Cohorts of PRISM II Study 4Avanir Pharmaceuticals Announces Positive Top-line Results from Stroke and TBI Cohorts of PRISM II Study 5Avanir Pharmaceuticals Announces Positive Top-line Results from Stroke and TBI Cohorts of PRISM II Study 6Avanir Pharmaceuticals Announces Positive Top-line Results from Stroke and TBI Cohorts of PRISM II Study 7
(Date:6/30/2015)... ... June 30, 2015 , ... The LIV Fertility Center in ... and deciding the right age to pursue egg freezing. Statistics show that 20 percent ... 35 — a 150 percent increase since the 1970s. , Sadly, for women who ...
(Date:6/30/2015)... ... June 30, 2015 , ... Today, Grand Terrace Health ... Health Care Center.” Each year, Medicare ranks care centers around the country in ... for their needs. Grand Terrace prides itself on quality in each of Medicare’s ...
(Date:6/30/2015)... ... June 30, 2015 , ... According to a recent report by the ... heroin-related deaths more than tripled in the same period—leading a majority of law enforcement ... Center , a leading Florida-based drug treatment facility, asserts that these heroin statistics point ...
(Date:6/30/2015)... ... June 30, 2015 , ... ... today that they have been awarded the exclusive billing agreements with Jackson Radiology ... of billing services encompassing their proprietary suite of billing process software functionality called ...
(Date:6/30/2015)... ... June 30, 2015 , ... On June 26, 2015, Harper’s Bazaar Magazine ... triggers that most people would not expect to cause acne flare-ups. The ... causes of acne are clogged pores and bacteria and each of the ...
Breaking Medicine News(10 mins):Health News:LIV Fertility Center Educating Women on the Critical Timing of Egg Freezing 2Health News:LIV Fertility Center Educating Women on the Critical Timing of Egg Freezing 3Health News:LIV Fertility Center Educating Women on the Critical Timing of Egg Freezing 4Health News:LIV Fertility Center Educating Women on the Critical Timing of Egg Freezing 5Health News:Grand Terrace Health Care Center Announces Five-Star Rating in YouTube Video 2Health News:Novus Medical Detox Center Urges Education and Action as New DEA Report Reveals Rising Heroin Use and Deaths 2Health News:Novus Medical Detox Center Urges Education and Action as New DEA Report Reveals Rising Heroin Use and Deaths 3Health News:Novus Medical Detox Center Urges Education and Action as New DEA Report Reveals Rising Heroin Use and Deaths 4Health News:ADVOCATE Wins Billing Agreements with Jackson Radiology Associates 2Health News:A List of 5 Surprising Acne Triggers and the Latest Acne Treatment Options 2
... are significantly more likely to experience difficulties during childbirth //and ... of the gruesome practice, a new United Nations study has ... evidence of the harmful effects for women and children, calls ... women worldwide., ,The serious complications during childbirth it cites ...
... commitment' to the global fight against HIV/AIDS, India ... // and discrimination against victims and expand its ... girls. ,'The soundness of India's strategy ... in Tamil Nadu which had high incidence of ...
... a programme organized by ‘Elements Regazzo’ in association with ... Chennai at the Taj Coromandel hotel on June 9th ... to spread HIV/AIDS //awareness amongst the youth. ... Shamita Shetty, Vikram, Ganesh Hegde, Ran Vijay along with ...
... Bombay High Court has provided succour to a couple by ... their inability to produce a marriage certificate as required by ... yesterday, directed city-based Bombay Hospital to relax its rules and ... wife Sushila (56). ,Chandrabhan could not donate an ...
... Naughty boys can dry up your coffers and bring it to ... say that rearing an ill-behaved child// turns out to be an ... It is estimated that a raucous child can inflict damages to ... of an additional ?6,000 annually on an average. ,But ...
... passed into the footnotes of history and all the usual noises ... risk factor for lung cancer and a variety of other diseases//. ... that the health authorities are trying to convey. ,Why ... lies in the fact that smoking is addictive and it needs ...
Cached Medicine News:
... Designed to inform decision making, ... patient data on demand. Clinicians ... to lab results, medication profiles, ... profiles, and clinical notes such ...
... Thermo Labsystems was designed specifically to combine ... such as the new fast dial system ... help to define this as a new ... interchangeable handle plate offers a custom fit ...
Research Series 2100 Adjustable-volume Pipette, 0.1-2.5 l, single-channel with adjustable-volume setting...
Pipetman P is a fully adjustable, air-displacement pipette with the selected volume shown on a digital indicator (volumeter). Eight models cover the full range of volumes from 0.2 L to 10 mL....
Medicine Products: