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Early Coronary Artery Healing Advantage of OrbusNeich's Combo Dual Therapy Stent™ Compared to the TAXUS® Stent Shown in Two Clinical Trial Subgroup Analyses
Date:5/17/2012

fessor of medicine at Columbia University College of Physicians and Surgeons in New York. "There is a trend of differences in morphology that may support the Combo Stent's approach of improved vascular healing while maintaining effective control of neointimal proliferation."

A second study evaluated 23 baseline and 15 follow-up VH-IVUS assessments of a subset of patients from the REMEDEE trial to assess the vascular healing response of the Combo Stent compared to the TAXUS stent at nine months. The Combo Stent showed less neointimal proliferation and significantly less confluent necrotic core than the TAXUS stent. The necrotic core volume in the neointimal hyperplasia had an average of 2.8 mm3 in the Combo Stent compared to 4.2 mm3 in the TAXUS stent. Additionally, the Combo Stent had predominantly homogeneous fibrotic neointima.

"The Combo Stent is the only technology that combines the value of endothelial progenitor cell capture to promote vessel healing with an abluminal sirolimus drug elution to limit neointimal proliferation," said Stephen M. Rowland, Ph.D., vice president of research and development at OrbusNeich. "We are committed to bringing innovation to interventional cardiologists to help them address unmet needs with contemporary percutaneous coronary intervention."  

The Combo Stent, the world's first dual therapy stent (DTS), combines an abluminal biodegradable sirolimus elution for the regulation of hyperplasia with Genous™, OrbusNeich's proven endothelial progenitor cell (EPC) capture technology, to accelerate re-endothelialization.

About the Genous Technology

Genous is OrbusNeich's patented EPC capture technology that promotes the accelerated natural healing of the vessel wall after the implantation of blood-contact devices such as stents. The technology consists of an antibody surface coating that attracts EPCs circulating in the blood to the device to form an endothelial l
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SOURCE OrbusNeich
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