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EXAMINE-Studie zur kardiovaskulären Sicherheit von Alogliptin erreicht primären Endpunkt: keine Erhöhung des kardiovaskulären Risikos bei Risikopatienten mit Typ-2 Diabetes
Date:9/11/2013

sgemäß den Behörden mitgeteilt.

Informationen zu Diabetes Typ 2
Diabetes Typ 2 ist die häufigste Form von Diabetes, unter der Millionen Menschen weltweit leiden. Diabetes Typ 2 ist eine fortschreitende und chronische Erkrankung; Patienten sollten ihre Erkrankung regelmäßig von einem Arzt kontrollieren lassen. Neben Diät und Bewegung müssen die Patienten häufig ein oder mehrere Medikamente einnehmen, um ihren Blutzuckerspiegel unter Kontrolle zu halten. Der „International Diabetes Federation" zufolge beliefen sich die Gesundheitsausgaben für Diabetes (Typ 1 und 2) im Jahr 2012 auf mehr als 471 Milliarden USD. Es wird geschätzt, dass dieser Betrag bis 2030 595 Milliarden USD überschreiten wird.

Informationen zu Alogliptin
Alogliptin ist ein Dipeptidylpeptidase-4-Inhibitor (DPP-4i) zur Behandlung von Diabetes Typ 2 bei Erwachsenen, in Ergänzung zu Diät und Bewegung. DPP-4is verlangsamen die Deaktivierung der Incretin-Hormone GLP-1 und GIP. Durch eine erhöhte Menge an aktiven Inkretinen kann die Bauchspeicheldrüse Insulin Glukose-abhängig sezernieren und so die Kontrolle des Blutzuckerspiegels unterstützen. Das japanische Ministerium für Gesundheit, Arbeit und Wohlfahrt ließ im April 2010 eine New Drug Application (NDA) für NESINA (Alogliptin) zur Behandlung von Diabetes Typ 2 zu; das Medikament ist in Japan unter eben diesem Markennamen erhältlich. NESINA (Alogliptin) wurde von der US-amerikanischen FDA im Januar 2013 sowohl als  Monotherapie als auch als Kombinationstherapie  (fixed-dose combination, FDC) mit Pioglitazon (OSENI) und Metformin (KAZANO) für die Behandlung von Diabetes Typ 2 bei Erwachsenen als Ergänzung zu Diät und Bewegung zugelassen. Alogliptin als Monopräparat ist gegenwärtig in Tablettendosierungen zu 6,25 mg,
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SOURCE Takeda Pharmaceutical Company Limited
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