Navigation Links
EXAMINE-Studie zur kardiovaskulären Sicherheit von Alogliptin erreicht primären Endpunkt: keine Erhöhung des kardiovaskulären Risikos bei Risikopatienten mit Typ-2 Diabetes
Date:9/11/2013

mit mittlerem Beobachtungszeitraum von 18 Monaten; Risikoverhältnis 0,96; obere Grenze des Konfidenzintervalls (KI) 1,16. Alogliptin ist ein Dipeptidylpeptidase-4-Inhibitor (DPP-4i) zur Behandlung von Diabetes Typ 2 bei Erwachsenen.

„Wir brauchen sicherere Diabetestherapien für Patienten mit einem erhöhten Risiko für kardiovaskuläre Erkrankungen", erklärte William B. White, MD, FASH, FAHA, FACP, leitender Forscher der EXAMINE-Studie. „Aufgrund der Auslegung der EXAMINE-Studie und der behandelten Hochrisiko-Patienten liefern diese Ergebnisse Klinikern, die Diabetespatienten mit Koronarerkrankungen behandeln, wertvolle Einblicke."

Die globale EXAMINE-Studie ist von Bedeutung, da sie die kardiovaskuläre Sicherheit bei Patienten mit erhöhtem Risiko für kardiovaskuläre Erkrankungen (KVE) ermittelt. KVE sind die Hauptursache für Morbidität und Mortalität bei Patienten mit Typ-2-Diabetes.

Es wurden insgesamt 5.380 Patienten zwischen 18 und 40 Monate nachbeobachtet. Die Anzahl an vorzeitigen Studienabbrüchen in beiden Gruppen war ähnlich. Die Patienten erhielten auch eine umfassende Standardtherapie für Diabetes Typ 2 und begleitende kardiovaskuläre Risikofaktoren.

„Das Design der EXAMINE-Studie und vor allem die gemessenen Ergebnisse machen diese Studie besonders interessant für die Diabetesbehandlung von Patienten mit hohem Risiko", sagte Ajay Ahuja, MD, Vice President, Global Medical Affairs, Takeda. „Im Laufe der vergangenen 20 Jahre hat Takeda eine solide Expertise für die Diabetesbehandlung aufgebaut und diese stets erweitert. EXAMINE zeigt unser anhaltendes Engagement für die Entwicklung neuer Produkte wie Alogliptin und für eine optimierte Behandlung des Diabetes Typ 2."

Der wichtigste sekundäre Endpunkt bestand aus den Komponenten des prim
'/>"/>

SOURCE Takeda Pharmaceutical Company Limited
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8

Related medicine technology :

1. American College of Chest Physicians (ACCP) und Simbionix arbeiten zusammen, um klinische Ausbildung und Patientensicherheit zu verbessern
2. Messe/Konferenz InnoPack Pharma legt den Fokus auf innovative Verpackungen für Compliance und Sicherheit
3. Takeda EXAMINE Cardiovascular Safety Outcomes Trial of Alogliptin Met Primary Endpoint of Non-Inferiority Compared to Placebo in Addition to Standard of Care Showing No Increase in Cardiovascular Risk in Type 2 Diabetes Patients at High-Risk for Car
4. Takeda Type 2 Diabetes Therapies, NESINA (alogliptin) and Fixed-Dose Combinations KAZANO (alogliptin and metformin HCl) and OSENI (alogliptin and pioglitazone), Are Now Available in Pharmacies in the United States
5. Takeda Receives FDA Approval for Three New Type 2 Diabetes Therapies, NESINA (alogliptin) and Fixed-Dose Combinations OSENI (alogliptin and pioglitazone) and KAZANO (alogliptin and metformin HCl)
6. Takeda Resubmits New Drug Applications to the United States Food and Drug Administration for Alogliptin and the Fixed-Dose Combination Alogliptin and Pioglitazone
7. National Diabetes Volunteer Leadership Council (NDVLC) Urges FDA to Enforce Stringent Accuracy Standards for Blood Glucose Monitoring Systems
8. Clinilabs Sponsors The ADAs 2013 Step Out: Walk to Stop Diabetes
9. GSMA mHealth Grand Tour Highlights How Mobile Technology Could Help Prevent 5 Million People In The EU From Developing Diabetes
10. Elcelyx Therapeutics NewMet for Type 2 Diabetes Meets Primary Endpoint in Phase 2b Study
11. Bio-Solutions Corp. Expanding in Booming Diabetes Market
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2015)... plc (NYSE: MNK ) announced today that ... program. The open-ended authorization permits the company to repurchase ... "Funding additional initiatives and seeking attractive ... to pursue a range of focused growth strategies," said ...
(Date:1/22/2015)... 22, 2015  BiOptix is pleased to announce the appointment ... of Chemistry and Biochemistry. Scott joins the company after previous ... Amgen throughout the course of his nearly 20 year ... is a nationally recognized thought leader in the biosensor ...
(Date:1/22/2015)... Jan. 22, 2015  Bio-Techne Corporation (NASDAQ: TECH ... first member of the new Simple Plex platform through ... launch represents the re-branding of the previously acquired CyPlex ... platform is a transformative immunoassay technology which integrates an ...
Breaking Medicine Technology:Mallinckrodt plc Announces Share Repurchase Program 2Mallinckrodt plc Announces Share Repurchase Program 3Mallinckrodt plc Announces Share Repurchase Program 4BiOptix Expands Leadership Team with the Appointment of Dr. Scott Klakamp as Vice President of Chemistry and Biochemistry 2Bio-Techne Launches Simple Plex Platform 2Bio-Techne Launches Simple Plex Platform 3
(Date:1/22/2015)... 22, 2015 The City of West Hollywood hosted ... to commemorate the 42nd anniversary of the Supreme Court decision Roe ... been 42 years since the Roe vs. Wade decision and the ... present as ever,” said City of West Hollywood Councilmember Abbe Land. ...
(Date:1/22/2015)... The Incredible Bulk is a revolutionary method put together ... by up to 30lbs in less than 12 weeks without ... Stevenson, prompting an investigative review. , “Our Incredible Bulk ... formula that allows the body to pack on a massive ...
(Date:1/22/2015)... Orlando, Florida (PRWEB) January 22, 2015 ... up today at the 2015 PGA Merchandise Show to ... lady and incredible female amateur golfer, Arlene McKitrick. The ... career female amateur golf tournament win. She won her ...
(Date:1/22/2015)... January 22, 2015 Carinsurancesavings.biz has released a ... death and dismemberment insurance . , Purchasing an accidental ... be very advantageous. This type of rider provides benefits if ... can be considered a lesser form of life insurance. ...
(Date:1/22/2015)... Florida (PRWEB) January 22, 2015 IsoComforter, Inc. ... therapy machine with patented IsoTube design to treat specific body ... introduced the most progressive and easy to use patented cold ... post-operative and sports related orthopedic and muscle injuries. IsoComforter ...
Breaking Medicine News(10 mins):Health News:The Incredible Bulk: Review Examining Ben Pakulski’s Brand New Bulking Muscle Building Diet Program Released 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2Health News:IsoComforter Introduces Best of Class Cold Therapy Product to the Worldwide Market 2
... coronary artery stenosis, according to a large study performed ... , The study consisted of 1,331 patients who ... stenosis. 10,561 coronary artery segments were analyzed during the ... significant coronary artery stenosis in our patients; specificity was ...
... used a new imaging technique to take high quality ... in mice, and the technology could help in the ... may cause blindness. , The study, "The Clinical Time-Course ... with Histologic and Cellular Infiltrate Correlation," was published in ...
... Hopkins University has received a $4.97 million grant from ... initial phase of a unique program aimed at improving ... with the Johns Hopkins Center for Global Health, and ... Uganda. As part of the initiative, the faculties of ...
... OAKLAND, Calif., Dec. 1 As President Bush seeks,to ... which will especially,adversely impact healthcare services and workplace safety, ... new,website inviting web browsers to help "send Bush packing,", ... The site offers an interactive game highlighting some of ...
... Dec. 1 Mach One Corporation,(Pink Sheets: MNCN), a ... long term benefit to the agricultural and consumer,market, announced ... Board,of Directors effective upon the closing of the acquisition ... Mr. Ballantyne is ...
... For difficult to diagnose patients,Breast-Specific Gamma Imaging (BSGI) is ... ultrasound for patients who need additional imaging,following a questionable ... meeting of the Radiological Society of North America (RSNA).,BSGI ... lesions independent,of tissue density and discover very early stage ...
Cached Medicine News:Health News:New technique captures high-res images of full retina 2Health News:Johns Hopkins and Makerere University to collaborate on African health education initiative 2Health News:Johns Hopkins and Makerere University to collaborate on African health education initiative 3Health News:Citing 'Midnight Rules' to Erode Health and Safety, Nurses Unveil New Website to Send Bush Packing 2Health News:Mr. Tad Ballantyne to Join Mach One Board of Directors 2Health News:Molecular Breast Imaging Performs Better Than Ultrasound in Patients With Mammographic Abnormalities 2
... M1 is an advanced desktop PC ... is a sophisticated 2 channel stimulation ... electrical stimulations, 2 sound stimulations and ... You can customize each stimulation independently. ...
... high performance magnetic stimulator for use in both ... ,MagPro is able to stimulate with repetition rates ... field/nerve interface can be done using the ability ... direction. , , , , ,MagPro is ...
... X-SIZER System is a ... for thrombus removal in ... saphenous vein grafts. ... cutter and,continuous evacuation. ...
... Allura Xper is the perfect partner for ... these systems are scalable to meet your ... come.,Flexibility means that your Allura Xper FD20 ... cardiac use. Openness to new technologies allows ...
Medicine Products: