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ESBATech's Antibody Fragment Enters Phase Ib/IIa in Ophthalmology
Date:2/3/2009

racts are the leading cause of vision loss in adults that are 55 and older and are the leading cause of blindness worldwide. By age 65, about half of the human population has a cataract, and by age 75, almost everyone has a cataract. Surgery is the only effective treatment for cataracts and involves removing the cloudy lens and replacing it with an artificial lens. Over 90 percent of patients operated for cataract surgery gain a useful vision, but like any other surgery, problems may develop occasionally such as post-surgery inflammation. If poorly controlled, a condition called macular edema can be caused by inflammation, which when becoming chronic, leads to permanent damage to the retinal architecture and loss of visual acuity.

About ESBATech's Antibody Fragment Platform Technology

ESBATech is the first and only company to date that has successfully screened and characterized the entire human pool (1.5 million) of naturally occurring variable immunoglobulin (VH and VL) domains to select highly stable, soluble and monomeric single-chain antibody fragment frameworks. ESBATech's unique, scientific approach to stabilize monomeric, single-chain antibody fragments (scFvs) using its proprietary fully-human antibody fragment frameworks has elucidated the drug-like properties of these proprietary scFvs. The company is advancing a pipeline of novel antibody fragment therapeutics for topical and/or local delivery, to ensure safe and convenient patient therapy.

About ESBATech AG

ESBATech AG is a Zurich, Switzerland-based, privately held, clinical-stage biotechnology company concentrating in research, development and commercializing its fully human single-chain antibody fragments via local and topical administration. The company was the first to non-invasively deliver an ophthalmic biologic drug via eye drops elucidating a depot effect in the eye's vitreous. ESBATech's lead antibody fragment, ESBA105, is in clini
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