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ESBATech's Antibody Fragment Enters Phase Ib/IIa in Ophthalmology
Date:2/3/2009

nly four months after successful completion of our Phase I trial. We are very confident that our topically available TNF-alpha inhibitor has a great potential in several ophthalmic indications. To our knowledge, ESBA105 is the most advanced topical antibody fragment in ophthalmology and this study will provide important information on pharmacokinetic and efficacy in the human eye."

Peter Lichtlen, M.D., Ph.D., Head of Clinical Development at ESBATech AG, commented, "We are very excited to report the initiation of this study. TNF-alpha is a well known and well characterized drug target for inflammatory conditions. However, the spectrum of potential indications in ophthalmology lies way beyond classical inflammatory diseases. In our preclinical studies that we have just published in IOVS, we were able to demonstrate excellent penetration of ESBA105, topically applied as eye drops to both anterior and posterior segment of the eye. In particular, topical administration of ESBA105 results in significant levels in the vitreous body which is of significant importance for many ocular diseases. In addition, only very low systemic exposure is observed, adding to the excellent safety profile that was confirmed in our recent healthy volunteer Phase I trial. As a component of the current human PK trial, we are going after all these pharmacological data as well. Demonstrating anticipated therapeutic concentrations of ESBATech's antibody fragments with eye drops represents a major step forward in treatments for important ocular conditions."

ESBA105 is also being studied in other therapeutic indications such as osteoarthritis (OA). Earlier this year, ESBATech initiated a Phase I/IIa clinical study to explore clinical activity of ESBA105 in osteoarthritis of the knee.

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A cataract is a clouding of the normally clear lens of the eye, usually caused by age-related changes in the lens structure. Cata
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