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ESAs and a New Class of Late Stage Oral HIF-PH Inhibitors May Be Impacted by the Fact That Nephrologists Report Initiating ESAs at Lower Hemoglobins
Date:4/4/2013

EXTON, Pa., April 4, 2013 /PRNewswire/ -- BioTrends Research Group, one of the world's leading research and advisory firms for specialized biopharmaceutical issues, finds that, compared to just one year ago, the mean hemoglobin at erythropoiesis-stimulating agent (ESA) initiation has significantly declined and is nearing levels at which a blood transfusion may be required. In addition, nephrologists tend to overestimate the percent of stage 3 chronic kidney disease (CKD) patients on an ESA, but accurately assess the percent of patients being treated with an ESA in stage 4 and stage 5 non-dialysis. Amgen's Aranesp has a slightly higher share of late-stage CKD patients than do the other available ESAs, including Procrit (manufactured by Amgen and distributed by Janssen) and Amgen's Epogen.

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The ChartTrends®: Renal Anemia in CKD-ND 2012 (U.S.) report also covers the use of oral iron and IV iron in CKD-ND patients. AMAG Pharmaceutical's Feraheme, in number two share position behind Venofer, recently announced FDA acceptance of supplemental new drug application for label expansion to include iron deficiency anemia patients who cannot take oral iron. In addition, this study found that Feraheme patient share has declined directionally from 2011 with directional increases of the use of Sanofi's Ferrlecit."In this study, nearly half of physicians report initiating ESAs in CKD-ND at lower hemoglobin levels in the past year, something evident in the patient audit portion of this study as well," said BioTrends Research Group Director of Nephrology Rob Dubman . "This repor
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SOURCE BioTrends Research Group
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