Navigation Links
ENDECE Neural to Present Findings for Remyelination at 2013 Keystone Symposia on Multiple Sclerosis

MEQUON, Wis., Nov. 28, 2012 /PRNewswire/ -- ENDECE Neural, LLC ( announced today that Dr. Steven Nye, Vice President of Discovery, will be presenting at the 2013 Keystone Symposia on Multiple Sclerosis to be held in January, in Big Sky, Montana, USA. 

Dr. Nye's presentation, "Estrogen analogs dramatically up-regulate intracellular signaling pathways for remyelination (1)," will review the mechanism behind the novel ENDECE Neural compounds that induce remyelination in rodent animal models of Multiple Sclerosis (MS). 

"Unlike current MS therapeutics, which target immune response and inflammation to slow relapses, ENDECE Neural is developing the first drug compounds to induce remyelination of demyelinated axons, and potentially reverse disease progression," states Dr. Nye.

Abstract below:
Estrogen analogs dramatically up-regulate intracellular signaling pathways for remyelination.

A new series of nuclear receptor ligands was synthesized for treating multiple sclerosis and other neurodegenerative disorders. The ligands are analogs of 17beta-estradiol (E2) that bind to the estrogen receptors (ERs) and induce distinct intracellular responses which can determine cell fate. Based on molecular modeling studies, modifications to the core structure of E2 were made with different C-6 alkoxyalkyl moieties and/or substitution of the C-18 methyl group. The E2 alterations caused pronounced changes in subtype selectivity for ER-alpha or ER-beta, along with varying degrees of ER dimerization and ER activation. Microarray studies revealed that several of the E2 analogs cause a dramatic up-regulation of genes in signaling pathways related to OPC differentiation and myelin sheath production. While all three E2 analogs are ER agonists, NDC-1308 was the most potent at causing mouse OPC differentiation concomitant with myelin basic protein expression in vitro. The findings presented here relate the structure of the E2 analogs to biological function. We conclude that cellular responses for neuronal repair/remyelination may be controlled to some extent by making key alterations to the core structure of endogenous ER ligands. 

(1) Steven H. Nye, ENDECE, LLC, Mequon, WI, USA 53092; Wei Xu, University of Wisconsin, McArdle Laboratory for Cancer Research, Madison, WI, USA 53706; Michael Bittner, Translational Genomics Research Institute, Scottsdale, AZ, USA 85004; Robert E. Babine, Rebexsess Discovery Chemistry, Encinitas, CA, USA 92024;  James G. Yarger, ENDECE, LLC, Mequon, WI, USA 53092.

About ENDECE Neural, LLC (an ENDECE Company)
ENDECE Neural is the wholly owned subsidiary of ENDECE, LLC. ENDECE Neural was founded in 2011 to focus on the development of what could be the first drug capable of inducing remyelination of damaged nerve axons, and potentially restoring muscle control, mobility and independence to the lives of Multiple Sclerosis patients. ENDECE Neural maintains an exclusive license for the IP from its parent company.

Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Neuralstem Updates ALS Stem Cell Trial Progress
2. Sixteenth Patient Dosed In Neuralstem ALS Stem Cell Trial
3. First Patients Dosed in Ib Phase of Neuralstems NSI-189 Trial in Major Depressive Disorder
4. Seventeenth Patient Dosed in Neuralstem ALS Stem Cell Trial
5. Neuralstem Announces Exercise Of Entire Over-Allotment Option By Aegis Capital Corp.
6. Neuralstem Grants First Licenses For CNS Therapy Surgical Devices
7. Neuralstem Announces Proposed Public Offering
8. Neuralstem to Raise $7.0 Million in Registered Direct Offering
9. Neuraltus Pharmaceuticals Announces Phase 2 Clinical Results for NP001 in Patients with Amyotrophic Lateral Sclerosis (ALS)
10. MRI Interventions Named 2012 Global Company of the Year in Image-Guided Neural Interventions
11. Report Presents a Framework for Successful New Oncology Product Launches in the Pharmaceutical Sector
Post Your Comments:
(Date:11/25/2015)... -- Henry Schein, Inc., the world,s largest provider of health ... animal health practitioners, will unveil at the Greater New ... Pavilion , which brings together for the first time ... help any practice or laboratory enter the digital age. ... of experts appearing at the Pavilion. --> ...
(Date:11/25/2015)... 25, 2015  Trovagene, Inc. (NASDAQ: TROV ), ... Chief Executive Officer Antonius Schuh, Ph.D., is scheduled to ... Annual Piper Jaffray Healthcare Conference. th ... Palace Hotel in New York ... Mr. Schuh will be available for one-on-one meetings during ...
(Date:11/25/2015)... 25, 2015 Endo International plc (NASDAQ: ENDP ... , President and CEO, will discuss corporate updates at the ... New York on Wednesday, December 2, 2015 ... on Investor Relations, and then the link to the event. ... start time to visit the site and download any streaming ...
Breaking Medicine Technology:
(Date:11/25/2015)... ... , ... On November 10, 2015, Bohrer Brady, LLC filed a class and ... a home health care worker who provided companionship services for the elderly, ill or ... by Humana, Inc., Humana at Home, Inc., and SeniorBridge Family Companies (CT), Inc. since ...
(Date:11/25/2015)... ... November 25, 2015 , ... According to an article published ... and more widely heralded as a breakthrough for performing hernia repairs. The article explains ... laparoscopic surgery is that it can greatly reduce the pain that a patient might ...
(Date:11/25/2015)... ... November 25, 2015 , ... Dental professionals who would like to become ... invited to attend Dr. Mark Iacobelli’s Advanced Implant Mentoring (AIM) CE course. Courses will ... , As the co-founders of Advanced Implant Mentoring (AIM), Dr. Iacobelli and Dr. D’Orazio ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... athletic programs, launches new Wimbledon Athletics Facebook page to educate the ... for unsuspected cardiac abnormalities. About 2,000 people under the age of 25 die ...
(Date:11/25/2015)... ... November 25, 2015 , ... On November 23rd 2015 Cozy ... personal heating products business. Cozy Products explains what this means for business moving ... well with the Cozy Products business model: to sell personal heaters that reduce energy ...
Breaking Medicine News(10 mins):