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ECLIPSE Data on Effects of Otsuka's Investigational Novel Treatment, Tolvaptan, on Advanced Heart Failure Patients' Hemodynamics and Urine Output Featured in Heart Failure Society of America's Late Breaking Trials
Date:9/19/2007

xpenses related to HF tally about $28 billion, ACC estimates. The majority of patients hospitalized for ADHF, the worsening of chronic HF that affects 1 million US residents annually, have edema or excess body fluid.

About Otsuka Pharmaceutical Development & Commercialization, Inc.

Otsuka Pharmaceutical Development and Commercialization, Inc. is involved in conducting all phases of clinical research and development of innovative healthcare products to address unmet medical needs. OPDC is well established in the scientific community as a globally focused organization that plays a leadership role in the research and development of Otsuka's ethical healthcare products. The Company is dedicated to the improvement of the quality of human life and health of patients around the world with a strong commitment to research and development in the areas of cardiovascular, neuroscience, renal and respiratory diseases, as well as cancer and ophthalmic disorders. OPDC is part of the Otsuka Pharmaceutical Group, which is comprised of 99 companies and approximately 31,000 people around the world. With 54 consolidated subsidiaries, Otsuka earned US $7.2 billion in consolidated annual revenues in fiscal 2006. For additional information, visit http://www.otsuka.com.

(1) SHAPE Survey Results to the General Public, Annual Congress of the

European Society of Cardiology in Vienna, September 2003.

(2) ACC News Release, ''American College of Cardiology / American Heart

Association guidelines: New heart failure guidelines stress early

diagnosis and treatment,'' August 16, 2005. Accessed at

http://www.acc.org/media/releases/highlights/2005/aug05/hf%5Fguideline% 5Fupdat

e.htm on March 1, 2007. (Due to length of URL, please cut and paste into browser.)


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